Bethesda, MDJuly 11, 2012 Listed below are the selected highlights for the July 2012 issue of the Genetics Society of America's journal, Genetics. The July issue is available online at www.genetics.org/content/current. Please credit Genetics, Vol. 191, JULY 2012, Copyright 2012.
Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations, pp. 959-967
Nicholas A. Furlotte, Eun Yong Kang, Atila Van Nas, Charles R. Farber, Aldons J. Lusis, and Eleazar Eskin
Because mouse models have a long history in the study of human disease, many studies describe the association of mouse genetic variation and disease traits. Their power can be increased by combining the results through the statistical procedure of meta-analysis, but the differing ancestry of the mouse panels used in each study can pose complications. These authors introduce a technique to combine studies, while accounting for differing ancestry, and they show how their method increases the potential to discover genomic regions underlying disease traits.
Multiple barriers to nonhomologous DNA end joining during meiosis in Drosophila, pp. 739-746
Eric F. Joyce, Anshu Paul, Katherine E. Chen, Nikhila Tanneti, and Kim S. McKim
Nonhomologous end joining (NHEJ) is to be suppressed in meiosis. This article provides insight into how Drosophila does that. Two groups of proteins that promote homologous recombinationMCM-like protein MEI-218 and Rad51-related proteins RAD51C and XRCC3suppress NHEJ during meiotic prophase. The authors suggest that those proteins regulate early events in the double-strand break repair response, such as resection, which influences the particular pathway of repair.
Properties and power of the Drosophila S
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