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Genetics Society of America's Genetics journal highlights for April 2013
Date:4/1/2013

iversity. These investigators present new methods for analyzing data from admixed populations and show how statistics based on linkage disequilibrium can be used to construct a robust test for admixture and to infer admixture-related parameters such as dates, mixture proportions, and phylogenetic relationships. These tools are offered in a fast and flexible software packageALDERand applied to human data, yielding new insights into the admixture history of Sardinians, Pygmies, and Japanese.

Population and Evolutionary Genetics

6. Correcting coalescent analyses for panel-based SNP ascertainment, pp. 1185-1196
James R. McGill, Elizabeth A. Walkup, and Mary K. Kuhner

SNP chips only detect previously identified variants. Analyzing them as if they are fully ascertained leads to biased estimates of population size and other parameters; culling low-frequency SNPs makes the bias worse. This article offers corrections allowing accurate estimation of population parameters from panel-based and frequency-culled SNPs, and recommends strategies for SNP-based data collection and analysis.

Cellular Genetics

7. Nonself recognition through intermolecular disulfide bond formation of ribonucleotide reductase in Neurospora, pp. 1175-1183
Robert P. Smith, Kenji Wellman, Leila Haidari, Hirohisa Masuda, and Myron L. Smith

In addition to its task of manufacturing DNA nucleotides, ribonucleotide reductase has a surprising function in Neurospora crassa: nonself recognition. These investigators discovered that the flexible tail of the enzyme irreversibly crosslinks two alternative forms of the enzyme via an unusual disulfide bond. Their observation that different versions of this tail inhibit the growth of cells that carry the other allelic form offers the possibility of developing specific chemotherapeutic drugs using this system as a prototype.

Genome and Systems Biology

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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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