Genetics of Complex Traits
3. The protein chaperone HSP90 can facilitate the divergence of gene duplicates, pp. 1269-1277
Jennifer Lachowiec, Tzitziki Lemus, James H. Thomas, Patrick J. M. Murphy, Jennifer L. Nemhauser, and Christine Queitsch
Because protein chaperones facilitate folding and stability of their client proteins, clients may be free to accumulate more mutations than nonclients experiencing similar evolutionary pressures. These investigators found that a plant HSP90 client protein shows relaxed selection and hallmarks of neo- and subfunctionalization compared to its nonclient paralog. In addition, they show that systematically identified yeast HSP90 clients also tend to evolve faster than their nonclient paralogs.
Genome Integrity and Transmission
4. Limited RNA editing in exons of mouse liver and adipose, pp. 1107-1115
Sandrine Lagarrigue, Farhad Hormozdiari, Lisa J. Martin, Frdric Lecerf, Yehudit Hasin, Christoph Rau, Raffi Hagopian, Yu Xiao, Jun Yan, Thomas A. Drake, Anatole Ghazalpour, Eleazar Eskin, and Aldons J. Lusis
How prevalent is RNA editing? Several recent studies of RNA editing of exons in humans and mice reached very different conclusions. This article should quiet the controversy. Employing stringent criteria, the authors identified only 63 examples of editing in liver and 188 in adipose tissue of mice. Their results suggest that exonic RNA editing in these tissues is limited to perhaps a few hundred events.
Population and Evolutionary Genetics
5. Inferring admixture histories of human populations using linkage disequilibrium, pp. 1233-1254
Po-Ru Loh, Mark Lipson, Nick Patterson, Priya Moorjani, Joseph K. Pickrell, David Reich, and Bonnie Berger
Admixture between previously separated populations shapes patterns of genetic d
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Genetics Society of America