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Genetics Society of America's GENETICS journal highlights for November 2012
Date:11/7/2012

factor binding sites are roughly ten nucleotides long. This article shows how natural selection can explain this general feature of gene regulation. When the length and information content of binding sites are allowed to evolve, in a population-genetic model, they become constrained in an evolutionarily stable region. The predicted region coincides with the range of binding site lengths observed in nature.

Nonrandom X chromosome inactivation is influenced by multiple regions on the murine X chromosome, pp. 1095
Joanne L. Thorvaldsen, Christopher Krapp, Huntington F. Willard, and Marisa S. Bartolomei
The X chromosome controlling element (Xce) that causes nonrandom X chromosome inactivation in F1 hybrid mice was described more than 40 years ago. This article describes genetic studies that reveal multiple elements on the X chromosome that contribute to Xce activity. This genetic approach uncovers candidate Xce regions that were not exposed by conventional mutational analyses.

High-throughput discovery of mutations in tef semi-dwarfing genes by next-generation sequencing analysis, pp. 819
Qihui Zhu, Shavannor M. Smith, Mulu Ayele, Lixing Yang, Ansuya Jogi, Srinivasa R. Chaluvadi, and Jeffrey L. Bennetzen
Because orphan crops did not participate in the Green Revolution, no semi-dwarf varieties are available to ameliorate lodging of crops such as tef (Eragrostis tef), a major cereal crop in Ethiopia. Recessive mutations like those responsible for semi-dwarf varieties of rice, sorghum, and pearl millet are difficult to obtain in this allotetraploid species. These investigators used next-generation DNA sequencing to identify mutations in two homeologous dwarfing genes, providing germplasm with the potential to increase tef productivity.

This Month's Perspectives

Genome evolution due to allopolyploidization in wheat, pp. 763
Moshe Feldman and Avraham A. Levy
Polyploidization in pla
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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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