Elucidating molecular networks that either affect or respond to plasma cortisol concentration in target tissues of liver and muscle, pp. 1109
Siriluck Ponsuksili, Yang Du, Eduard Murani, Manfred Schwerin, and Klaus Wimmers
Cortisol has physiological implications for neurobiological, immune, and metabolic processes. This study addresses the genetics of variation in cortisol concentrations by integrating global gene expression and genome-wide association analyses of the level of expression quantitative trait loci detection with causality modeling. The study revealed genes that affect or respond to cortisol levels that are thus of interest in stress biology and animal breeding.
Pathways of genetic adaptation: Multistep origin of mutants under selection without induced mutagenesis in Salmonella enterica, pp. 987
Semarhy Quiones-Soto, Andrew B. Reams, and John R. Roth
Bacterial populations plated on growth-limiting medium give rise to well-adapted mutant colonies that accumulate above a lawn of nongrowing cells. This has been attributed to stress-induced mutagenesis of nongrowing cells, but this article presents evidence that this behavior can result from pre-existing small-effect mutations that enable growth and adaptation under selection, with no change in mutation rate.
Why transcription factor binding sites are ten nucleotides long, pp. 973
Alexander J. Stewart and Joshua B. Plotkin
From bacteria to humans, transcription
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Genetics Society of America