Bethesda, MDNovember 7, 2012 Listed below are the selected highlights for the November 2012 issue of the Genetics Society of America's journal, GENETICS. The November issue is available online at www.genetics.org/content/current. Please credit GENETICS, Vol. 192, November 2012, Copyright 2012.
Please feel free to forward to colleagues who may be interested in these articles.
An ex vivo model for imprinting: Mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation, pp. 857
Jennifer A. Erwin, Brian del Rosario, Bernhard Payer, and Jeannie T. Lee
X chromosome inactivation (XCI) is initially seen only on the parental X chromosome during embryogenesis. This imprinted XCI later becomes random, occurring on either the maternal or paternal X. This article describes a cell culture model for imprinting, discovery of a protein required for imprinted XCI, and the roles of two transcription factors in the switch between imprinted and random XCI in the early mouse embryo.
Small- and large-effect quantitative trait locus interactions underlie variation in yeast sporulation efficiency, pp. 1123
Kim Lorenz and Barak A. Cohen
Sporulation efficiency in yeast is a complex trait controlled by alleles of both large and small effect. These investigators report that small-effect alleles differ depending on which large-effect alleles are present in the background, suggesting there are strong interactions between large- and small-effect alleles. Curiously, each large-effect allele had a nearby small effect allele, suggesting that variable alleles for a trait may cluster together in the genome.
Ancient admixture in human history, pp. 1065
Nick Patterson, Priya Moorjani, Yontao Luo, Swapan Mallick, Nadin Rohland, Yiping Zhan, Teri Genschoreck, Teresa W
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