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Genetics Society of America's GENETICS journal highlights for November 2012
Date:11/7/2012

Bethesda, MDNovember 7, 2012 Listed below are the selected highlights for the November 2012 issue of the Genetics Society of America's journal, GENETICS. The November issue is available online at www.genetics.org/content/current. Please credit GENETICS, Vol. 192, November 2012, Copyright 2012.

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ISSUE HIGHLIGHTS

An ex vivo model for imprinting: Mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation, pp. 857
Jennifer A. Erwin, Brian del Rosario, Bernhard Payer, and Jeannie T. Lee
X chromosome inactivation (XCI) is initially seen only on the parental X chromosome during embryogenesis. This imprinted XCI later becomes random, occurring on either the maternal or paternal X. This article describes a cell culture model for imprinting, discovery of a protein required for imprinted XCI, and the roles of two transcription factors in the switch between imprinted and random XCI in the early mouse embryo.

Small- and large-effect quantitative trait locus interactions underlie variation in yeast sporulation efficiency, pp. 1123
Kim Lorenz and Barak A. Cohen
Sporulation efficiency in yeast is a complex trait controlled by alleles of both large and small effect. These investigators report that small-effect alleles differ depending on which large-effect alleles are present in the background, suggesting there are strong interactions between large- and small-effect alleles. Curiously, each large-effect allele had a nearby small effect allele, suggesting that variable alleles for a trait may cluster together in the genome.

Ancient admixture in human history, pp. 1065
Nick Patterson, Priya Moorjani, Yontao Luo, Swapan Mallick, Nadin Rohland, Yiping Zhan, Teri Genschoreck, Teresa W
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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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