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Genetics Society of America's GENETICS journal highlights for May 2013
Date:4/30/2013

highly complex genomes. A unique Weighted Gene Co-Expression Network Analysis approach was used to compare gene expression networks in mature wheat embryos from two distinct growing environments across a segregating population. This approach identified environmentally conserved and unique co-expression modules and their genetic control.

Cellular Genetics
The innate immune response transcription factor Relish is necessary for neurodegeneration in a Drosophila Model of ataxia-telangiectasia, pp. 133-142
A. J. Petersen, R. J. Katzenberger, and D. A. Wassarman
Neurodegeneration is a hallmark of the human disease ataxia-telangiectasia (A-T), which is caused by mutation of the A-T mutated (ATM) gene. These investigators found that activation of an NF-KB-mediated innate immune response in glial cells causes neurodegeneration in Drosophila ATM mutants. Their finding that Relish, one of the three NF-KB proteins in flies, is necessary for neurodegeneration suggests that neurodegeneration in human A-T is caused by activation of a specific NF-KB protein in glial cells.

Population and Evolutionary Genetics
Identifying loci under selection against gene flow in isolation-with-migration models, pp. 211-233
V. M. Sousa, M. Carneiro, N. Ferrand, and J. Hey
When diverging populations hybridize, regions of the genome near genes associated with population differences or hybrid incompatibilities are prevented from moving from one population to the other. Thus some genes move more freely than others between diverging populations. This article describes a method for estimating rates of gene flow at multiple loci and for identifying loci with reduced gene flow. The authors apply the method to two subspecies of rabbits to show how gene flow can be restricted.

Population and Evolutionary Genetics
Higher levels of Neanderthal ancestry in East Asians than in Europeans, pp. 199-209
J. D. Wall, M. A
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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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