Navigation Links
Genetics Society of America's GENETICS journal highlights for May 2013

Bethesda, MDApril 30, 2013 Listed below are the selected highlights for the May 2013 issue of the Genetics Society of America's journal, GENETICS. The May issue is available online at Please credit GENETICS, Vol. 194, MAY 2013, Copyright 2013.

Please feel free to forward to colleagues who may be interested in these articles on a wide array of topics including: developmental and behavioral genetics; genome integrity and transmission; genetics of complex traits; cellular genetics; and population and evolutionary genetics.


Developmental and Behavioral Genetics
An organelle gatekeeper function for Caenorhabditis elegans UNC-16 (JIP3) at the axon initial segment, pp. 143-161
S. L. Edwards, S.-c. Yu, C. M. Hoover, B. C. Phillips, J. E. Richmond, and K. G. Miller
Nerve cell bodies have a vastly different organelle composition than axons. This article (see accompanying commentary by Zheng and Nonet, pp. 35-37) provides insight into the basis of this difference. The authors report the discovery of a previously unrecognized organelle gatekeeper function, mediated by UNC-16 (JIP3 in humans), that acts at the axon initial segment to restrict the flow of Golgi and endosomal organelles into the synaptic region of axons.

Genome Integrity and Transmission
Novel proteins required for meiotic silencing by unpaired DNA and siRNA generation in Neurospora crassa, pp. 91-100
T. M. Hammond, H. Xiao, E. C. Boone, L. M. Decker, S. A. Lee, T. D. Perdue, P. J. Pukkila, and P. K. Shiu
Identification of small RNAs associated with meiotic silencing by unpaired DNA, pp. 279-284
T. M. Hammond, W. G. Spollen, L. M. Decker, S. M. Blake, G. K. Springer, and P. K. Shiu
Genes unpaired during meiosis are silenced in Neurospora by a mechanism known as meiotic silencing by unpaired DNA (MSUD). Two articles in this issue of GENETICS report the identification of novel players in this process, including small RNAs and the first nuclear MSUD protein. This protein is not required for meiosis, providing the first indication that MSUD is not necessarily coupled to sexual development.  

Genome Integrity and Transmission
Intragenomic conflict between the two major knob repeats of maize, pp. 81-89
L. B. Kanizay, P. S. Albert, J. A. Birchler, and R. K. Dawe
Large genomes are often replete with tandem repeats. Why do they exist? Here the authors investigate the distribution of tandem repeats in maize heterochromatic domains called knobs. The data suggest an intragenomic conflict whereby one family of repeats suppresses proliferation of the other. Similar competition may underlie the formation and maintenance of many tandem repeat arrays.

Genome Integrity and Transmission
Nonrandom distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae, pp. 69-80
W. Song, M. Gawel, M. Dominska, P. W. Greenwell, E. Hazkani-Covo, K. Bloom, and T. D. Petes
This article presents the first high-resolution mapping of the positions of chromosome breaks that result from the bridge-fusion-breakage cycles of dicentric chromosomes. Sites of recombination between a dicentric chromosome and its normal homolog revealed the locations of breaks in the dicentric chromosome, which were distributed in a quasi-random fashion between the two centromeres.

Genetics of Complex Traits
Systems genetics of environmental response in the mature wheat embryo, pp. 265-277
J. D. Munkvold, D. Laudencia-Chingcuanco, and M. E. Sorrells
This article illustrates the utility of network approaches for understanding gene expression by environment interaction, even in organisms with highly complex genomes. A unique Weighted Gene Co-Expression Network Analysis approach was used to compare gene expression networks in mature wheat embryos from two distinct growing environments across a segregating population. This approach identified environmentally conserved and unique co-expression modules and their genetic control.

Cellular Genetics
The innate immune response transcription factor Relish is necessary for neurodegeneration in a Drosophila Model of ataxia-telangiectasia, pp. 133-142
A. J. Petersen, R. J. Katzenberger, and D. A. Wassarman
Neurodegeneration is a hallmark of the human disease ataxia-telangiectasia (A-T), which is caused by mutation of the A-T mutated (ATM) gene. These investigators found that activation of an NF-KB-mediated innate immune response in glial cells causes neurodegeneration in Drosophila ATM mutants. Their finding that Relish, one of the three NF-KB proteins in flies, is necessary for neurodegeneration suggests that neurodegeneration in human A-T is caused by activation of a specific NF-KB protein in glial cells.

Population and Evolutionary Genetics
Identifying loci under selection against gene flow in isolation-with-migration models, pp. 211-233
V. M. Sousa, M. Carneiro, N. Ferrand, and J. Hey
When diverging populations hybridize, regions of the genome near genes associated with population differences or hybrid incompatibilities are prevented from moving from one population to the other. Thus some genes move more freely than others between diverging populations. This article describes a method for estimating rates of gene flow at multiple loci and for identifying loci with reduced gene flow. The authors apply the method to two subspecies of rabbits to show how gene flow can be restricted.

Population and Evolutionary Genetics
Higher levels of Neanderthal ancestry in East Asians than in Europeans, pp. 199-209
J. D. Wall, M. A. Yang, F. Jay, S. K. Kim, E. Y. Durand, L. S. Stevison, C. Gignoux, A. Woerner, M. F. Hammer, and M. Slatkin
Neanderthals occupied most of Europe and parts of Western Asia from 30-300 thousand years ago, and coexisted with modern humans during part of that time. These authors found that modern day East Asians contain on average more Neanderthal DNA than do modern day Europeans. They also show that the East African Maasai contain some Neanderthal ancestry, probably due to recent back-migration of modern humans into Africa.

Genetics of Complex Traits
Genetic dissection of a major anthocyanin QTL contributing to pollinator-mediated reproductive isolation between sister species of Mimulus, pp. 255-263
Y.-W. Yuan, J. M. Sagawa, R. C. Young, B. J. Christensen, and H. D. Bradshaw Jr.
What underlies prezygotic barriers that lead to reproductive isolation, and ultimately, to speciation? The bumblebee-pollinated Mimulus lewisii and hummingbird-pollinated M. cardinalis are a classic example of pollinator-mediated prezygotic reproductive isolation. These investigators identified an anthocyanin pigment regulatory gene causing a flower color difference that contributes to pollinator preference for each species. This gene is likely to play a role in flower color variation in many other plants.

Cellular Genetics
The nuclear Argonaute NRDE-3 contributes to transitive RNAi in Caenorhabditis elegans, pp. 117-131
J. J. Zhuang, S. A. Banse, and C. P. Hunter
RNA interference (RNAi) was initially perceived as a cytoplasmic gene silencing process, but genes important for RNAi in C. elegans were found to operate in the nucleus. This article describes unexpected features of one such gene underlying a nuclear RNAi defective (nrde) mutant, which emphasizes the importance of nuclear events during RNAi silencing, especially for transitive RNAia mechanism central to RNAi amplification.

This Month's Perspectives
Charles Darwin's mitochondria, pp. 21-25
J. Hayman
Scholars have long speculated over the nature of Charles Darwins debilitating illness, with most diagnoses stressing psychogenic roots. In this Perspectives, John Hayman proposes that Darwin suffered from a mitochondrial genetic disease, MELAS syndrome, caused by a maternally inherited, relatively common A3243G point mutation in the mitochondrial chromosome. Here the hypothesis is examined by a review of Darwin's symptoms, in comparison to MELAS syndrome, and by an examination of related illnesses in his maternal family.


Contact: Phyllis Edelman
Genetics Society of America

Related biology news :

1. Genetics defines a distinct liver disease
2. Ludwig presents advancements in immunotherapy and epigenetics at the American Association for Cancer Research Annual Meeting
3. Ludwig advancements in immunotherapy and epigenetics top scientific program at AACR
4. Genetics Society of Americas Genetics journal highlights for April 2013
5. Epigenetics studies take root in plants
6. Education resource focuses on teaching population genetics using current research
7. Spiral Genetics Closes $3 Million in Funding Led by DFJ and Announces Partnership with Omicia
8. Epigenetics mechanism may help explain effects of moms nutrition on her childrens health
9. Oxfords Gero Miesenböck is awarded The Brain Prize 2013 for his pioneering work on optogenetics
10. Genetics Society of Americas Genetics journal highlights for March 2013
11. Geneticist Svante Pääbo receives the $500,000 Gruber Genetics Prize
Post Your Comments:
(Date:11/17/2015)... PARIS , November 17, 2015 ... November 2015.   --> Paris from ... --> DERMALOG, the biometrics innovation leader, has invented the ... and fingerprints on the same scanning surface. Until now two ... fingerprints. Now one scanner can capture both on the same ...
(Date:11/17/2015)... Nov. 17, 2015  Vigilant Solutions announces today that ... Board of Directors. --> ... retiring from the partnership at TPG Capital, one of ... over $140 Billion in revenue.  He founded and led ... the TPG companies, from 1997 to 2013.  In his ...
(Date:11/16/2015)... , Nov 16, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced expansion of its TDDI ... touch controller and display driver integration (TDDI) ... smartphones. These new TDDI products add to the ... resolution), TD4302 (WQHD resolution), and TD4322 (FHD resolution) ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh ... Insertion points for in-line sensors can represent a weak spot where leaking process ... series of retractable sensor housings , which are designed to tolerate extreme process ...
(Date:11/24/2015)... , ... November 24, 2015 , ... ... OrthoAccel® Technologies, Inc., on being named to Deloitte's 2015 Technology Fast 500 list ... facility, OrthoAccel manufactures AcceleDent®, a FDA-cleared, Class II medical device that speeds up ...
(Date:11/24/2015)... ANGELES , Nov. 24, 2015 ... biotechnology company focused on the discovery, development and commercialization ... , Ph.D., Chief Executive Officer, is scheduled to present ... 1, 2015 at 10:50 a.m. EST, at The Lotte ... City . . ...
(Date:11/24/2015)... 24, 2015  PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI ... company,s president and chief executive officer, will present at the ... in New York City . The presentation ... 1, 2015 at 9:30 a.m. EST. ... website at least 15 minutes prior to the presentation to ...
Breaking Biology Technology: