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Genetics Society of America’s GENETICS journal highlights for August 2012
Date:8/9/2012

egans", pp. 1031-1035
Elizabeth A. De Stasio
This is the first of a new series of articles in GENETICS Educational Primers designed to guide educators in the use of current scientific literature in the classroom (see editorial in this issue). In this Primer, Elizabeth De Stasio explains how Polley and Fay used RNA interference, suppressor screens, and synthetic phenotypes to elucidate the function of the retinoblastoma protein in C. elegans (see article in this issue). Each Primer provides necessary background for students and offers a sample approach to classroom use of the original article, including discussion questions.

A resolution of the mutation load paradox in humans, pp. 1321
Yann Lesecque, Peter D. Keightley, and Adam Eyre-Walker
It has been estimated that each of us receives, on average, at least two new harmful mutations from our parents. Previous theoretical work suggested that this high rate of harmful mutation should result in 88% of individuals failing to have offspring, and each female having to have more than 16 offspring on average, to maintain population size. Fortunately, those calculations are incorrect, as these authors show. They show that humans could tolerate hundreds of new harmful mutations if natural selection acts via competition between individuals.

SNP-ratio mapping (SRM): Identifying lethal alleles and mutations in complex genetic backgrounds by next-generation sequencing, pp. 1381
Heike Lindner, Michael T. Raissig, Christian Sailer, Hiroko Shimosato-Asano, Rmy Bruggmann, and Ueli Grossniklaus
Mutations in essential genes are difficult to identify. Here the authors present a method for quick identification of homozygous-lethal alleles by next-generation sequencing. The authors' method, which can also be used to map second-site modifiers in complex genetic/transgenic backgrounds, can be applied to any genetic organism.

The mRNA decay path
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Contact: Phyllis Edelman
pedelman@genetics-gsa.org
301-634-7302
Genetics Society of America
Source:Eurekalert

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