Bethesda, MDAugust 9, 2012 Listed below are the selected highlights for the August 2012 issue of the Genetics Society of America's journal, GENETICS. The August issue is available online at www.genetics.org/content/current. Please credit GENETICS, Vol. 191, AUGUST 2012, Copyright 2012.
Please feel free to forward to colleagues who may be interested in these articles.
New negative feedback regulators of Egfr signaling in Drosophila, pp. 1213
Jonathan P. Butchar, Donna Cain, Sathiya N. Manivannan, Andrea D. McCue, Liana Bonanno, Sarah Halula, Sharon Truesdell, Christina L. Austin, Thomas L. Jacobsen, and Amanda Simcox
While much is known about the checks and balances necessary for the precise specification of fly wings, these authors show that we didn't know it all. They report the discovery of two new negative regulators in the Egfr pathway that are conserved in other animals. Because a perfect wing is of critical importance to flies, it is likely that more such controls will be discovered.
On the prospects of whole-genome association mapping in Saccharomyces cerevisiae, pp. 1345
Caitlin F. Connelly and Joshua M. Akey
Genome-wide association (GWA) studies have not caught on for model organisms. One challenge is population structure, which can result in spurious associations. This article shows that indeed, GWA studies in yeast are complicated by complex patterns of population structure that are not easily corrected by existing approaches. The authors expound on how careful study design and empirical tests of the effects of population structure will be necessary for carrying out GWA studies in model organisms.
Suppressors, screens, and genes: An educational primer for use with "A network of genes antagonistic to the LIN-35 retinoblastoma protein of Caenorhabditis el
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