Navigation Links
Genetically reprogrammed HSV given systemically shrinks distant sarcomas
Date:7/7/2010

CINCINNATI Scientists have used a genetically reprogrammed herpes virus and an anti-vascular drug to shrink spreading distant sarcomas designed to model metastatic disease in mice still an elusive goal when treating humans with cancer, according to a study in the July 8 Gene Therapy.

Less than 30 percent of patients with metastatic cancer survive beyond five years, despite the aggressive use of modern combination therapies, including chemotherapy. This creates a significant need for new sarcoma therapies to treat metastatic disease, said Timothy Cripe, M.D., Ph.D., a physician/researcher in the division of Hematology/Oncology at Cincinnati Children's Hospital Medical Center and the study's senior investigator.

The study results are even more significant because the oncolytic herpes virus, HSV-rRp450, was given to the mice systemically to attack tumors via the blood stream instead of being injected directly into tumors.

"Systemic bio-distribution has been a major stumbling block for using virus vectors in gene transfer and virotherapy to treat cancer, but we show that viruses can be used systemically by giving them intravenously to get an anti-tumor effect," Dr. Cripe said.

Also important to results of the current study was using the virus in conjunction with a drug (bevacizumab) that blocks the growth of tumor feeding-blood vessels. In the current study, researchers focused on spreading Ewing sarcoma and Rhabdomyosarcoma cancers that form in muscle, bone and connective tissue.

Anti-angiogenic agents like bevacizumab are usually given first in combination cancer therapies because they help enlarge intercellular openings to tumor cells and ease the delivery of drugs, such as chemotherapies. In this study, however, the researchers discovered that bevacizumab has to be given after the virus to maximize the anti-tumor effect of the combined therapy. In fact, giving bevacizumab first lowered the virus's up
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert  

0

GOOD

Page: 1 2

Related biology news :

1. Novel bioreactor enhances interleukin-12 production in genetically modified tobacco plants
2. Researchers genetically link Lou Gehrigs disease in humans to dog disease
3. Scientists unlock possible aging secret in genetically altered fruit fly
4. Cats eye diseases genetically linked to diseases in humans
5. Origins of wolverine in California genetically verified
6. Weed resistance to glyphosate in genetically modified soybean cultivation in Argentina
7. Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients
8. Genetically engineered mice yield clues to knocking out cancer
9. First genetically-engineered malaria vaccine to enter human trials
10. Genetically-modified mice reveal another mechanism contributing to heart failure
11. New study reveals first ever method to genetically identify all 8 tuna species
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetically reprogrammed HSV given systemically shrinks distant sarcomas
(Date:5/21/2013)... that the nation,s land and water resources could likely ... to 25 billion gallons of algae-based fuel a year ... needs. , The findings come from an in-depth look ... grow significant amounts of algae in large, specially built ... 7 issue of Environmental Science and Technology , ...
(Date:5/21/2013)... method for delivering molecules into single, targeted cells ... technique could find applications in drug delivery, cell ... a technique used to deliver molecules into ... that are caused by exposing them to electric ... cell transfection. (Cell transfection is the introduction of ...
(Date:5/21/2013)... Widely available in pharmacies and health stores, phosphatidylserine ... oysters, and soy. Proven to improve cognition and ... older people experiencing memory impairment. Now a team ... Bochner of Tel Aviv University,s Department of ... same supplement improves the functioning of genes involved ...
Breaking Biology News(10 mins):Going green: Nation equipped to grow serious amounts of pond scum for fuel 2Going green: Nation equipped to grow serious amounts of pond scum for fuel 3Going green: Nation equipped to grow serious amounts of pond scum for fuel 4Single-cell transfection tool enables added control for biological studies 2Common food supplement fights degenerative brain disorders 2
... waters interfere with fish reproduction by disrupting the fishes ... at Austin Marine Science Institute has found. Incidents ... have increased dramatically in coastal waters throughout the world ... of increased run-off from human agricultural and industrial activities. ...
... issue of the Journal of the American Dietetic Association contains ... is a summary of one of this months articles. ... Habits Later in Life , Eating together as a family ... quality in young adulthood, according to researchers at the University ...
... The past decade has witnessed an explosion of information ... in the development of obesity and the influence of ... food intake and metabolism. A symposium held recently in ... on recent work in talks by leaders in the ...
Cached Biology News:Low oxygen in coastal waters impairs fish reproduction 2Highlights from the September 2007 Journal of the American Dietetic Association 2Obesity and the central nervous system -- the state of the art 2
(Date:5/22/2013)... 2013 iLuv Creative Technology, the premier ... the mobile lifestyle, announces they are now shipping MultiCharger-X, ... multiple iPad devices efficiently. Winner of the 2013 internationally ... Design award, MultiCharger-X is revolutionizing the way businesses, schools, ... deployed. , MultiCharger-X (iAD910) combines the ...
(Date:5/22/2013)... 2013  Superior Controls, Inc. has been named ... NH Magazine.  For the past 22 years, the ... themselves with extraordinary business and civic excellence. ... honor," said Rick Pierro , ... this award is a reflection of Superior Controls, ...
(Date:5/22/2013)... 2013 Mold remediation could take a toll ... is a way to cut down the process' expense. And ... post the details of a method how to kill ... could be prevented, My Cleaning Products said. But in case ... a mold remediation must then be promptly implemented as it ...
(Date:5/22/2013)... 2013 The ability to sequence ... information they encode. There are now a suite ... of ribosome protected fragments) that dramatically expand our ... speakers include Dr. Jonathan Weissman, an Investigator with ... Hughes Medical Institute, who will present recent applications ...
Breaking Biology Technology:iLuv Now Shipping the All New MultiCharger-X 2iLuv Now Shipping the All New MultiCharger-X 3Superior Controls of Seabrook, NH named Business of the Year for 2013 by Business NH Magazine 2How to Kill Mold While Saving Thousands of Dollars on Mold Remediation Projects Explained by My Cleaning Products 2Monitoring Protein Synthesis One Codon at a Time Through Ribosome Profiling, a Webinar Hosted by Xtalks 2
... ... Management Solution for European Consortium Using Systems Biology to Study Infectious Diseases , ... (PRWEB) June 1, 2010 ... science research, today announced it has been selected to participate in an ERA-Net-funded applied ...
... 1 eResearchTechnology, Inc. (ERT), (Nasdaq: ERES ... the pharmaceutical, biotechnology, and medical device industries, announced the ... Division of CareFusion Corporation (CRS).  CRS is a leading ... devices and also offers cardiac safety and ePRO services. ...
... Italy , May 31, 2010 ... South East Asia Ltd.,scored two strategic wins by reaching ... and sterile,oncology patient doses in Kuala Lumpur ... first and only robot in the world proven to,automatically ...
Cached Biology Technology:Genedata Phylosopher Selected for ERA-NET sncRNA Project 2Genedata Phylosopher Selected for ERA-NET sncRNA Project 3Genedata Phylosopher Selected for ERA-NET sncRNA Project 4ERT Closes the Acquisition of the Research Services Division of CareFusion Corporation 2ERT Closes the Acquisition of the Research Services Division of CareFusion Corporation 3Health Robotics South East Asia Wins two key Cancer Therapy Outsourcing Projects in Malaysia and Thailand 2Health Robotics South East Asia Wins two key Cancer Therapy Outsourcing Projects in Malaysia and Thailand 3
... PBL's bioassays for interferons are cytopathic effect inhibition ... Sample types include; tissue culture supernatents; serum ... these assays, one unit is defined as the ... the cytopathic effect of viral infection by 50%. ...
HyPro 100, includes 5 x HyPro20 and HyPro Cabinet. 100 slide capacity. Active vibration system, slide rack and humidity chamber. Ideal for microarray and in situ hybridization....
... are cytopathic effect inhibition assays, also known as ... tissue culture supernatents; serum from PK studies and ... is defined as the quantity of interferon required ... viral infection by 50%. All standards ...
Request Info...
Biology Products: