Navigation Links
Genetically-modified mice reveal another mechanism contributing to heart failure
Date:2/1/2010

Scientists at the Robarts Research Institute at The University of Western Ontario, working in collaboration with researchers in Brazil, have used a unique genetically-modified mouse line to reveal a previously unidentified mechanism contributing to heart failure. The study, led by Marco Prado, Robert Gros and Vania Prado of London, Canada and Silvia Guatimosim of Brazil, shows how the decreased release of the neurotransmitter acetylcholine, a chemical messenger which slows cardiac activity, contributes to heart failure.

The study is published online in Molecular and Cellular Biology at http://mcb.asm.org/cgi/content/abstract/MCB.00996-09v1

Heart failure affects close to a half million Canadians, often as a result of conditions including coronary disease, high blood pressure, diabetes and high alcohol or drug consumption. Cardiac output is controlled using two opposing divisions of the autonomic nervous system: the sympathetic nervous system which boosts the heart rate and the parasympathetic system which slows it by releasing acetylcholine.

"Lots of people have studied the system that increases the heart rate and that has been the hallmark; we know there's an increase in the sympathetic nervous system in people who have heart failure," explains Gros, a cardiovascular researcher and assistant professor in the Departments of Physiology & Pharmacology and Medicine at Western's Schulich School of Medicine & Dentistry.

"What we're now showing with this mouse model is that even if you have a functional sympathetic nervous system, if the other system, the parasympathetic system is dysfunctional or works less optimally than normal, you still end up with a sick heart. This opens up a whole new avenue that people have missed in the past."

Marco and Vania Prado genetically modified a line of mice with decreased secretion of acetylcholine originally for use in studying neuronal function in diseases such as Alzheimer's. But they found these mice, over time, developed changes in their hearts that progressively decreased their ability to pump blood, similar to what occurs with heart failure in humans.

"There are other mouse and rat models of heart failure, but what we haven't had before is a model where we specifically target this chemical messenger, acetylcholine," says Marco Prado, a professor in the Departments of Physiology & Pharmacology and Anatomy & Cell Biology. "One striking finding in this study is that heart dysfunction in these mice could be corrected by treating the animals with an existing drug which increases acetylcholine levels. Although it requires further study, this could provide a novel opportunity for treating failing hearts." The drug, Pyridostigmine, is currently approved for use in treating certain cases of muscle weakness.


'/>"/>

Contact: Jeff Renaud
jrenaud9@uwo.ca
51-966-121-118-5165
University of Western Ontario
Source:Eurekalert

Related biology news :

1. Penn Veterinary Medicine report new strategy to create genetically-modified animals
2. Seeing the brain hear reveals surprises about how sound is processed
3. New study reveals red grouper to be Frank Lloyd Wrights of the sea
4. Promising candidates for malaria vaccine revealed
5. Parasitic wasps newly sequenced genomes reveal new avenues for pest control
6. Study reveals how one form of natural vitamin E protects brain after stroke
7. Final moments of bee landing tactics revealed
8. Genomes of identical twins reveal epigenetic changes that may play role in lupus
9. Pores finding reveals targets for cancer and degenerative disease
10. UR study reveals chemos toxicity to brain, possible treatment
11. New biosensors reveal workings of anti-psychotic drugs in the living brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... Dec. 15, 2016 Advancements in ... health wellness and wellbeing (HWW), and security ... three new passenger vehicles begin to feature ... recognition, heart beat monitoring, brain wave monitoring, ... monitoring, and pulse detection. These will be ...
(Date:12/15/2016)... -- "Increase in mobile transactions is driving the growth ... is expected to grow from USD 4.03 billion in ... CAGR of 29.3% between 2016 and 2022. The market ... for smart devices, government initiatives, and increasing penetration of ... expected to grow at a high rate during the ...
(Date:12/8/2016)... Market Research Future published a half cooked research report on Mobile ... Service Market is expected to grow over the CAGR of ~35% ... ... Mobile Biometric Security and Service Market is increasing at ... and security from unwanted cyber threats. The increasing use of mobile ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... , Jan. 20, 2017 Ginkgo ... of Gen9, a pioneer in the synthesis and ... unique expertise in assembling pathway-length synthetic DNA into ... and capacity in the construction of new organism ... industries. "Gen9 was founded to significantly ...
(Date:1/19/2017)... and HOUSTON , ... ("NX Prenatal") today announced the formation of its ... leading clinicians and industry veterans who enhance the ... as it accelerates development of its novel prenatal ... provide medical, clinical and strategic guidance for the ...
(Date:1/19/2017)... Md. and GAITHERSBURG, Md. ... (NYSE MKT: PIP) and Altimmune, Inc., a privately-held ... signing of a definitive agreement for the merger ... Altimmune,s current investors include Novartis Venture Fund, HealthCap, ... will be a fully-integrated and diversified immunotherapeutics company ...
(Date:1/19/2017)... (PRWEB) , ... January 19, 2017 , ... FireflySci Inc. ... exponential rate. The tremendous growth is accounted to two main factors. The ... and the expanding network of vendors supplying FireflySci products all around the world. , ...
Breaking Biology Technology: