Navigation Links
Genetically modified cell procedure may prove useful in treating kidney failure
Date:6/22/2010

INDIANAPOLIS A protein whose primary role is in the embryonic development of kidneys may play a future role in treating kidney failure.

Indiana University School of Medicine researchers have successfully treated acute kidney injury in laboratory experiments using cells that were genetically reprogrammed to produce the protein. The research suggests there could be a potential future treatment using such cells delivered intravenously instead of surgically.

Hospital health care professionals must deal with such renal problems during which the kidneys cannot adequately perform their critical roles of removing bodily waste in about five percent of all patients, and a much higher percentage of patients in intensive care units.

IU scientists Jesus Dominguez, M.D., and Katherine Kelly, M.D., report in the August issue of the American Journal of Physiology - Renal Physiology, available online, that they were able to treat acute kidney failure in animal models using cells modified to produce a protein that normally is found when kidneys first develop in embryos. That protein, called SAA, also is produced by the liver in periods of bodily stress, such as during infections, fever or surgery.

In earlier research they had found that applying the SAA protein directly to kidney cells caused those cells to produce tubules like those found in normal kidneys to remove waste products from the blood. Tests determined that the tubules were functional.

The next step was to test whether the protein could have a similar impact in living animals. However, the protein is not easily available, so the researchers modified kidney cells to produce the protein. When the cells were infused into rats with renal failure, their kidney function improved quickly and significantly, the researchers found.

"In other studies, protecting the kidney usually doesn't work after the injury has begun," said Dr. Kelly, assistant professor of medicine. "But this is a significant degree of protection of the kidney, especially for something given after the fact."

In addition, using images from the Indiana Center for Biological Microscopy, the researchers discovered that the infused cells integrated themselves into the kidneys, which showed much less physical damage than the untreated kidneys.

"Now we know that cells can be modified and made to integrate into the kidney from a long distance. So we can give the cells from a peripheral vein and they will go to the kidney and build up, from the inside out. So our model seems to be developing into a transplant model," said Dr. Dominguez, professor of medicine and a physician at the Roudebush VA Medical Center.


'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Related biology news :

1. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
2. Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective
3. Genetically engineered tobacco plant cleans up environmental toxin
4. Genetically-modified mice reveal another mechanism contributing to heart failure
5. New study reveals first ever method to genetically identify all 8 tuna species
6. First genetically-engineered malaria vaccine to enter human trials
7. Genetically engineered mice yield clues to knocking out cancer
8. Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients
9. Weed resistance to glyphosate in genetically modified soybean cultivation in Argentina
10. Origins of wolverine in California genetically verified
11. Cats eye diseases genetically linked to diseases in humans
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetically modified cell procedure may prove useful in treating kidney failure
(Date:1/22/2016)... , January 22, 2016 /PRNewswire/ ... announced the addition of the  "Global ... their offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ...
(Date:1/20/2016)... Jan. 20, 2016  Synaptics Incorporated (NASDAQ: ... solutions, today announced sampling of S1423, its newest ... and small screen applications including smartwatches, fitness trackers, ... round and rectangular shapes, as well as thick ... with moisture on screen, while wearing gloves, and ...
(Date:1/11/2016)... 2016 Synaptics Incorporated (NASDAQ: SYNA ), ... that its ClearPad ® TouchView ™ 4300 ... separate categories in the 8 th Annual Mobile ... Breakthrough. The Synaptics ® TDDI solution enables faster ... thinner devices, brighter displays and borderless designs. ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... February 11, 2016 ... or "Company") (OTCQB: PSID), a life sciences company ... its Thermomedics subsidiary, which markets the Caregiver® FDA-cleared ... plan in January 2016, including entering into agreements ... monthly sales growth, and establishing several near-term pipeline ...
(Date:2/10/2016)... Febr. 10, 2016 /PRNewswire/ - BioAmber Inc. (NYSE: BIOA ... announce that Mitsui & Co. Ltd., its partner in ... plant, is investing an additional CDN$25 million in the ... stake from 30% to 40%.  Mitsui will also play ... produced in Sarnia , providing dedicated ...
(Date:2/10/2016)... York (PRWEB) , ... February ... ... (NASDAQ: REGN) today announced that it has joined the Human Vaccines Project, ... for infectious diseases and cancer. , The Human Vaccines Project brings ...
(Date:2/10/2016)... ... 2016 , ... HOLLOWAY AMERICA, a leading custom stainless steel ... Chapter 21st Annual Vendor Exhibition on Thursday, February 18, 2016. The Rocky Mountain ... annual event, which will run from 3:00 p.m. - 8:30 p.m. at The ...
Breaking Biology Technology: