Navigation Links
Genetically engineered spider silk for gene therapy
Date:8/10/2011

Genetically engineered spider silk could help overcome a major barrier to the use of gene therapy in everyday medicine, according to a new study that reported development and successful initial laboratory tests of such a material. It appears in ACS' journal Bioconjugate Chemistry.

David Kaplan and colleagues note that gene therapy the use of beneficial genes to prevent or treat disease requires safe and efficient carriers or "vectors." Those carriers are the counterparts to pills and capsules, transporting therapeutic genes into cells in the body. Safety and other concerns surround the experimental use of viruses to insert genes. The lack of good gene delivery systems is a main reason why there are no FDA-approved gene therapies, despite almost 1,500 clinical trials since 1989. The new study focused on one promising prospect, silk proteins, which are biocompatible and have been used in everyday medicine and medical research for decades.

The scientists describe modifying spider silk proteins so that they attach to diseased cells and not healthy cells. They also engineered the spider silk to contain a gene that codes for the protein that makes fireflies glow in order to provide a visual signal (seen using special equipment) that the gene has reached its intended target. In lab studies using mice containing human breast cancer cells, the spider-silk proteins attached to the cancer cells and injected the DNA material into the cells without harming the mice. The results suggest that the genetically-engineered spider-silk proteins represent "a versatile and useful new platform polymer for nonviral gene delivery," the article notes.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Scientist urges government ruling on genetically engineered salmon
2. AgriLife Research genetically fingerprinting E. coli from watersheds
3. Clinical tests for medicines made from genetically modified plants
4. Plants can adapt genetically to survive harsh environments
5. FDA funds pediatric trial testing genetically reprogrammed HSV to treat cancer
6. Notre Dame and Wyoming scientists genetically engineer silkworms to produce artificial spider silk
7. Insecticides from genetically modified corn present in adjacent streams
8. Manatee subspecies genetically confirmed, but diversity challenge looms
9. Scientists find new evidence of genetically modified plants in the wild
10. Scientists find the first evidence of genetically modified plants in the wild
11. Woods noble rot fungus genetically decoded
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/15/2017)... 2017   ivWatch LLC , a medical device company focused ... announced receipt of its ISO 13485 Certification, the global standard for ... for Standardization (ISO®). ... 400 Continuous Monitoring device for the early detection of IV infiltrations. ... "This is an important milestone for ivWatch, ...
(Date:7/20/2017)... 2017 Delta (NYSE: DAL ) customers now can ... at Reagan Washington National Airport (DCA). ... Delta launches biometrics to board aircraft at Reagan ... Delta,s biometric boarding pass experience that ... now integrated into the boarding process to allow eligible Delta SkyMiles Members ...
(Date:6/30/2017)... , June 30, 2017 Today, ... developer and supplier of face and eye tracking ... Featured Product provider program. "Artificial ... innovative way to monitor a driver,s attentiveness levels ... from being able to detect fatigue and prevent ...
Breaking Biology News(10 mins):
(Date:8/17/2017)... ... 17, 2017 , ... CNA Finance Chief Research Analyst, Kenny ... update on Aytu Bioscience and cited promising increases in the prescription rates for ... for Natesto® have more than doubled since March of this year and on ...
(Date:8/17/2017)... , ... August 17, 2017 , ... ... research and personalized medicine, today announced the launch of a new breast cancer ... The study’s goal is to evaluate the potential for early detection of recurrent ...
(Date:8/16/2017)... ... , ... Tunnell Consulting announced today that four of the firm’s ... and Expo , to be held October 29 through November 1 in San Diego ... advance patient therapies.” , The ISPE Annual Meeting and Expo will feature several interactive ...
(Date:8/16/2017)... Arizona (PRWEB) , ... August ... ... proud to introduce the Fluidnatek® Electrospinning and Electrospraying ... electrospraying equipment scales from table-top equipment for the lab to fully automated ...
Breaking Biology Technology: