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Genetic variants of USF1 are associated with the increased risk for cardiovascular disease
Date:4/7/2008

d in autopsy. It turned out that USF1 variation significantly associated with the size of the areas of several types of arterial wall lesions, especially with calcification of the arteries.

Finally, when Kristiansson tested what effect the USF1 risk variants have on sudden cardiac death and incidence of CVD at the population level, she found out that the risk variant increased the risk of sudden cardiac death of the same study subjects. Furthermore, USF1 alleles associated with incidence of CVD in Finnish population follow-up cohorts. These associations were especially prominent among women, suggesting a sex specific effect, which has also been detected in subsequent studies.

In conclusion, USF1 seems to have a role in the etiology of CVD. Additional studies are warranted to identify functional variants and to study interactions between USF1 and other genetic or environmental factors. These studies, which uncover the details of the disease etiology, provide tools for the prevention and treatment cardiovascular disease, Kristiansson states.


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Contact: M.Sc. Kati Kristiansson
kati.kristiansson@ktl.fi
358-456-389-404
University of Helsinki
Source:Eurekalert

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