Navigation Links
Genetic variants associated with bronchodilator responsiveness
Date:10/25/2013

Boston, MA A new study from Brigham and Women's Hospital (BWH) reveals several new gene variants that are associated with how people living with chronic obstructive pulmonary disease (COPD) respond to inhaled bronchodilators. COPD is a progressive breathing disorder that limits airflow in the lungs. Bronchodilators are medicines used to alleviate respiratory disorder symptoms.

The abstract for this meta-analysis study will be presented at the American Society of Human Genetics 2013 meeting, Oct. 22 to 26 in Boston.

One of the research goals was to identify single nucleotide polymorphisms (SNPs) associated with bronchodilator responsiveness (BDR).

"Identifying single nucleotide polymorphisms associated with bronchodilator responsiveness may reveal genetic pathways associated with the pathogenesis of COPD and may identify novel treatment methods," said Megan Hardin, MD, BWH Channing Division of Network Medicine, lead study author.

The researchers used statistical methods to combine results from 5,789 Caucasian patients with moderate to severe COPD from four individual studies. The genotypes of over 700 African Americans with COPD were also analyzed.

Most (4,561) of the patients in the four cohorts studied had over 10 pack-years of smoking. The group whose members had greater than 5 pack-years of smoking totaled 364, and the cohort with greater than two and one-half years totaled 864.

All patients were genotyped, and their lung function was tested by spirometry before and after they used the bronchodilator medication albuterol, which relaxes muscles in the airways and increases air flow to the lungs. Spirometry measures the volume and flow of air that is exhaled.

The researchers investigated over 6.3 million unique SNPs from the patients' genotypes. They discovered four novel variants that rarely occur in the general population.

According to Hardin, there may be multiple genetic determina
'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-534-2208
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. Will a genetic mutation cause trouble? Ask Spliceman
3. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
4. Perception and preference may have genetic link to obesity
5. A foot in the door to genetic information
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Epigenetics and epidemiology -- hip, hype and science
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. First complete full genetic map of promising energy crop
11. Genetic research develops tools for studying diseases, improving regenerative treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Washington State University reveals how youth who work ... and the evidence lies in kids, saliva. ... Psychological Association,s Human-Animal Interaction Bulletin this ... a prevention perspective," said Patricia Pendry, a developmental ... under the skin" and the effects of prevention ...
(Date:4/24/2014)... University researchers are the first to sequence the genome ... eagle features that could lead to more effective conservation ... assumptions about golden eagle vision, indicating that the raptors ... previously thought. The genome also suggests that golden eagles ... realized. , Additionally, the genome provides thousands of ...
(Date:4/24/2014)... has been published in the Scientific Reports journal. ... Biology (a joint centre of CSIC and Pompeu Fabra University-UPF), ... decoded and we saw that it did not match with ... to sequence the complete genome and to make a functional ... belong to Louis XVI". , The functional genome analysis ...
Breaking Biology News(10 mins):'Horsing around' reduces stress hormones in youth 2'Horsing around' reduces stress hormones in youth 3Genome yields insights into golden eagle vision, smell 2The blood preserved in the pumpkin did not belong to Louis XVI 2
... 2010 Scientists at The Scripps Research Institute have solved the ... difficult to culture in the laboratory, providing scientists with useful ... when stem cells can be used for therapeutic purposes. ... Proceedings of the National Academy of Sciences (PNAS) during ...
... The world,s largest antimony mine has become the world,s ... antimony -- an element whose environmental and biological properties ... emergent contaminant," said IU Bloomington Ph.D. student Faye Liu, ... attention to it." Used in small quantities, antimony ...
... professor at NJIT, sees the use of terahertz rays ... bombers and other terrorist activities. Federici and his ... video camera invented in their laboratory that uses a ... could be used to scan airport passengers quickly and ...
Cached Biology News:Scripps Research scientists solve mystery of fragile stem cells 2Scripps Research scientists solve mystery of fragile stem cells 3A different kind of mine disaster 2A different kind of mine disaster 3NJIT physicist sees terahertz imaging as ultimate defense against terrorism 2NJIT physicist sees terahertz imaging as ultimate defense against terrorism 3
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/14/2014)... Histogen, Inc., a regenerative medicine company ... under simulated embryonic conditions, today announced that they have ... Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary multipotent ... is an amendment to the existing license between Histogen ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo ... institutes from the National Institutes of Health (NIH) to ... more effective treatments to patients on a faster timeline. ... Translational Sciences (NCATS) and the National Eye Institute (NEI) ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... steps towards producing Influenza A (H1N1) VLP vaccine for animal ... Novavax, Inc. (Nasdaq: NVAX ) and the ... Institute of Allergy and Infectious Diseases (NIAID), National Institutes of ... evaluation of a virus-like particle (VLP) vaccine candidate against the ...
... June 4 EUCODIS Bioscience, a company,developing enzymes ... today that it has successfully launched its first,commercial ... EUCODIS,Bioscience and can be supplied in a GMP-compliant ... manufacturers to improve,quality control, to the diagnostics industry, ...
... SYDNEY, June 3 /PRNewswire-Asia/ -- Pharmaxis (ASX: ... had raised A$47 million through a placement to,Australian and ... company,s balance sheet as Pharmaxis moves toward,the European and ... , Pharmaxis will issue 20 ...
Cached Biology Technology:Novavax and the NIH Agree to Evaluate a Virus-like Particle (VLP) Vaccine Candidate Against the Novel Influenza A (H1N1) Virus 2Novavax and the NIH Agree to Evaluate a Virus-like Particle (VLP) Vaccine Candidate Against the Novel Influenza A (H1N1) Virus 3Novavax and the NIH Agree to Evaluate a Virus-like Particle (VLP) Vaccine Candidate Against the Novel Influenza A (H1N1) Virus 4EUCODIS Bioscience Launches Beta-Lactamase for Antibiotics and Diagnostics Industries 2Pharmaxis Announces Placement of $47 Million and Share Purchase Plan 2
... On-Demand Cytometry The Guava ... blue laser based multiparameter cytometer with built-in ... you can screen plates of cells and ... of manipulating multiple tubes or having the ...
Methylation analysis of gene promoters using bilsulfite treatment of DNA and comparative DNA sequence analysis. Probe design and PCR included....
... Galaxy LIMS, Sophisticated Bioinformatics , Proprietary primer ... offer individual sample sequencing of PCR products, ... or double strand publication quality. Primer ... interest is 1.3 to 7 kilobytes long. ...
GLP-compliant, CLIA-certified DNA sequencing service. ASQ and SQA certified quality assurance staff. Auditors welcome....
Biology Products: