Navigation Links
Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
Date:1/8/2008

Philadelphia, PA, January 8, 2008 Schizophrenia is a developmental disorder with a large genetic component contributing to increased risk. Available antipsychotic medications treat some of the symptoms of schizophrenia, but are typically effective in only a subset of patients. Unfortunately, it is difficult to predict the effectiveness of a specific drug in any given individual with schizophrenia. John H. Krystal, M.D., Editor of Biological Psychiatry and affiliated with both Yale University School of Medicine and the VA Connecticut Healthcare System, notes that in this era of medicine, the selection of particular antipsychotic medications for particular patients with schizophrenia is more art than science. We have been seeking objective guides, perhaps biological tests, which would inform this process. A new study published in the January 1st issue of Biological Psychiatry provides some interesting data to aid in that goal.

The authors report that differential effectiveness of antipsychotic treatment was predicted, in a subset of patients with schizophrenia, by variants of the gene encoding for the regulator of G-protein signaling 4 (RGS4), a protein that regulates the functional consequences of activating neurotransmitter receptors. Dr. Daniel Campbell, corresponding author for this article, explains these results: By applying genetic analysis to the NIMH-funded Clinical Antipsychotic Trials of Intervention Effectiveness, we show that variants in a specific gene, RGS4, predict the effectiveness of different antipsychotic treatments. Our results also indicate that the predictive power of the RGS4 genetic variants differed between patients of self-reported African and European ancestry, and thus emphasize the importance of including multiple ethnic groups in a study.

The authors importantly note that their results will require replication, but the findings indicate that RGS4 contributes to both the severity of schizophrenia symptoms a
'/>"/>

Contact: Jayne Dawkins
ja.dawkins@elsevier.com
215-239-3674
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... working at the University of California, San Diego, have ... marks that control the activity of genes based on ... results from its application to human embryonic cells in ... September 21. , "All of our cells have the ... functions," said John Whitaker, lead author of the report. ...
(Date:9/19/2014)... Call it the Jimmy Durante of dinosaurs ... nasal profile. The new dinosaur, named Rhinorex ... University and Brigham Young University, lived in what ... during the Late Cretaceous period. , Rhinorex, which ... and a close relative of other Cretaceous hadrosaurs ...
(Date:9/19/2014)... species which over thousands of years has adapted to the ... that makes the cold dangerous for you. , This is ... and the cold provoking substance, called nonylphenol, comes from the ... suspected of being a endocrine disruptor, but when entering the ... ability to protect the cells in its body from cold ...
Breaking Biology News(10 mins):Program predicts placement of chemical tags that control gene activity 2New hadrosaur noses into spotlight 2Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3
... Researchers have been unable to build an ideal photonic ... ultrafast optical computers. But now, University of Utah chemists ... with the ideal, diamond-like structure: They are found in ... Brazil. It appears that a simple creature like ...
... of the greatest zoological mysteries for over a century. ... puzzling crustaceans, despite the plethora of these larvae in ... what y- larvae grow up to be. A study ... reports the transformation of the larvae into a previously ...
... the Great Lakes have prompted the need to better ... collaborative project is aimed at improving information for beach ... close beaches to protect public health. This collaborative effort ... and other federal, state and local agencies. ...
Cached Biology News:The photonic beetle 2The photonic beetle 3The photonic beetle 4The photonic beetle 5Clue to mystery crustacean in parasite form 2To swim or not to swim? 2
(Date:9/19/2014)... CORAL SPRINGS, Florida , September 19, 2014 /PRNewswire/ ... biotech companies release latest developments, patents and results of ... (OTC: GNSZ), Eli Lilly and Company (NYSE: ... ), Celgene Corporation (NASDAQ: CELG ) and ... (OTCQB: GNSZ), a leader in developing prodrug therapeutics for ...
(Date:9/19/2014)... 2014 , The first grants ... Paediatric Endocrinology (ESPE) Meeting  Investment supports innovative ... in the field of growth  , EMD ... Germany , today announced the first recipients of ... awards were announced during a Satellite Symposium organized by ...
(Date:9/18/2014)... About POCT POCT, ... clinical laboratory. It helps in making fast clinical ... medication. POCT is gaining popularity due to the ... as diabetes, heart disease, and obesity. It is ... to minimize errors during the diagnosis of patients. ...
(Date:9/18/2014)... , September 18, 2014 ... ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced the ... - Global Strategic Business Report" ... http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the worldwide ... Million by the following Product Segments: ...
Breaking Biology Technology:Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 2Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 3Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 4Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 5Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 6Biotech Companies Pushing Sector Higher With Recent Therapeutic Advancements & Patent Approvals - Company Wins Summary Judgment For Prodrug Patent 7EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3POCT Market in China 2014-2018 2Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3
... a positive third,quarter, the biotech industry continued its upward climb ... the state of the economy,and interest rate jitters as the ... Index, for example, rose an impressive 6.1% in,October -- in ... ahead of the,DJIA which was unchanged. "Entering the final ...
... COLUMBIA, Md., Nov. 1 Martek Biosciences,Corporation (Nasdaq: ... in the United,States District Court in Wilmington, Delaware, ... a permanent injunction in Martek,s favor,against the defendants ... Lonza, Ltd., Nutrinova Inc. and Nutrinova Nutrition Specialties ...
... provide free home caregiving to disabled veterans, ... its,2007 We Care For Veterans campaign to honor ... qualified disabled veterans. (Logo: http://www.newscom.com/cgi-bin/prnh/20070521/LAM004ALOGO ) ... are,donating 20 hours each of free in-home care ...
Cached Biology Technology:Biotech Continues Upward Climb in October 2Biotech Continues Upward Climb in October 3Biotech Continues Upward Climb in October 4Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 2Martek to Obtain Permanent Injunction Against Lonza in U.S. Patent Infringement Suit; Jury Verdict on Infringement of Two of Three Patents Upheld by Judge 3Homewatch CareGivers Launches 2007 We Care For Veterans Campaign 2
... intensely fluorescent and highly photostable FluoSpheres ... in a variety of applications requiring ... signal. Unfortunately, protein- and other macromolecule-labeled ... cause them to bind to non-target ...
Goat polyclonal to Duffy / FY / DARC...
SMVT (N-14)...
... Source: Tritirachium album Description: ... endopeptidase used in a wide range of applications ... peptide bonds mainly following the carboxyl group of ... and is classified as a serine protease. ...
Biology Products: