Navigation Links
Genetic testing not cost-effective in guiding initial dosing of common blood thinner
Date:1/19/2009

CINCINNATINew analyses led by the University of Cincinnati (UC) show that genetic testing used to guide initial dosing of the blood-thinner warfarin may not be cost-effective for typical patients with atrial fibrillation but may be for patients at higher risk for major bleeding.

This study is being published in the Jan. 20, 2009, edition of Annals of Internal Medicine.

Warfarin is commonly prescribed to prevent blood clotting, particularly for patients with atrial fibrillationa type of abnormal heart rhythm.

Mark Eckman, MD, professor of medicine at UC and lead investigator of the study, says the U.S. Food and Drug Administration changed the labeling for warfarin in 2007, suggesting that clinicians consider genetic testing before initiating therapy.

"There are certain genes that are known to contribute to an increased sensitivity to warfarin," he says. "The idea behind genetic testingalso known as pharmacogenetic-guided dosing is to help guide the initial, and possibly lower, dose of warfarin for patients found to possess certain variants of the genes cytochrome P450 CYP2C9 and vitamin K epoxide reductase, or VKORC1. The hope is that more accurate dosing will translate into decreased major bleeds during the initiation phase of warfarin dosing, which is the first month or so."

Eckman says the study looked at whether the benefit of testing is worth the costs associated with it.

Researchers first performed an analysis combining the results of the only three clinical studies published to date to determine the degree to which pharmacogenetic-guided dosing decreases the risk of major bleeds when compared with standard induction of treatment with warfarin.

The team next constructed a model to estimate the cost-effectiveness of a genotype-guided dosing strategy.

While they found that genotype-guided dosing resulted in better outcomes, it was at a relatively high costover $170,000 per quali
'/>"/>

Contact: Katie Pence
katie.pence@uc.edu
513-558-4561
University of Cincinnati
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rethinking the genetic theory of inheritance
2. Biologist enhances use of bioinformatic tools and achieves precision in genetic annotation
3. MUHC and McGill scientists explain genetic disease first discovered in Quebec 24 years ago
4. New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease
5. Growth of new brain cells requires epigenetic switch
6. Studies examine genetic determinants of ADHD
7. Genetic mutation causes familial susceptibility for degenerative brain disease
8. New genetic markers for ulcerative colitis identified, researchers report in Nature Genetics
9. Genetic variation may lead to early cardiovascular disease
10. Scientists make strides toward defining genetic signature of Alzheimers disease
11. Safe new therapy for genetic heart disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... VILNIUS, Lithuania , Nov. 4, 2014 /PRNewswire/ ... identification technologies, today announced that the latest version ... place in the Ongoing MINEX evaluation ... interoperability of fingerprint algorithms using the INCITS 378 ... a mandatory requirement in public tenders in ...
(Date:11/3/2014)... A University of Colorado Cancer Center study ... Academy of Sciences describes the activity of a ... Interleukin 37 or IL-37. It has been known to ... in the adaptive immune system: IL-37 inhibits the ability ... antigens. , "Knowing this mechanism that underlies IL-37,s effect ...
(Date:11/3/2014)... and preterm birth are linked to increased risk for ... the American College of Rheumatology (ACR) journal, Arthritis ... and pre-term babies were not at greater risk of ... According to the ACR, 27 million Americans over the ... of OA range from mild to severe and include ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2
... discovery by Monash University scientists could see humble cotton ... devices capable of detecting diseases such as kidney failure ... have used ordinary cotton thread and sewing needles to ... is the size of a postage stamp. Microfluidic ...
... look identicalnot to mention drabto the human eye. But that,s ... essentially colorblind. A new study published online on February 25th ... that the fish can easily tell one species from another ... on their faces. Although scientists have long known that ...
... that a microbe called Trichodesmium , a member of ... budget. New research results reported on-line today in a ... may have to share its nitrogen-fixing throne: two others ... UCYN-A and Crocosphaera watsonii , are also abundant in ...
Cached Biology News:How long is a piece of thread? Long enough to save a life 2Fish can recognize a face based on UV pattern alone 2More than 1: Long-reigning microbe controlling ocean nitrogen shares the throne 2
(Date:11/26/2014)... Dallas, Texas (PRWEB) November 26, 2014 ... Bifluoride Industry” is a professional and in-depth research ... Ammonium Bifluoride information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/26/2014)... 26, 2014 The Alliance for ... survey of European physicians at the "1 ST ... Biological Therapies" at the Spanish Ministry of Health, ... EuropaBio and the Spanish Bioindustry Association (ASEBIO), included ... from Spanish oncology and rheumatology societies, representatives from ...
(Date:11/26/2014)... November 25, 2014 SonaCare Medical, ... Ultrasound (HIFU) devices, recently participated in the American ... Mass 360° .” Key opinion leaders in urology ... related to small renal masses while attendees had ... ablative technologies in hands-on labs. Attendees at the ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 Miles Holder, ... joined the Graphel Carbon Products team as Sales/Marketing Manager. ... marketing, and customer service for the graphite industry. , ... to our team,” stated Dave Trinkley, VP of Market ... wide range of experience in the graphite industry, along ...
Breaking Biology Technology:Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2
... 2011 Sigma-Aldrich® (NASDAQ: SIAL ) ... Directors declared a quarterly cash dividend of $.18 per share. ... of record on December 1, 2011. The Board ... the Company,s repurchase authorization.  This action brings the total authorization ...
... Star Line Group , U.S. Advisors ... reinsurance program in response to the final regulations published recently ... "We recognize the unique requirements of organizations that want ... need to moderate their downside risk in an affordable fashion," ...
... Nov. 8, 2011 ACCESS PHARMACEUTICALS, INC. ... proprietary drug-delivery platforms to develop treatments in areas of ... it has entered into an agreement with a major ... CobOral technology for the targeted delivery of RNAi therapeutics. ...
Cached Biology Technology:Sigma-Aldrich (NASDAQ: SIAL) Declares Quarterly Dividend. 2New ACO Reinsurance Program Launched by Star Line Group, U.S. Advisors and Ascendent Care 2Access Pharmaceuticals Signs Agreement for CobaCyte® and CobOral® in RNAi Therapeutic Delivery 2Access Pharmaceuticals Signs Agreement for CobaCyte® and CobOral® in RNAi Therapeutic Delivery 3
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
... technology incorporating the sophisticated DirectDrive architecture ... new Varian NMR System is undeniably ... ,The Varian NMR System features parallel ... channel, providing pulse sequence programming power ...
... Immunogen : Recombinant human ... 5mg/ml BSA, 0.15M NaCl, 0.05% ... of glycerol to 30% Quality ... on acid extracts of murine ...
Biology Products: