Navigation Links
Genetic testing may help select women with ER+ breast cancer for extended hormone therapy
Date:3/19/2014

Glasgow, UK: Genetic analyses of results from 1125 postmenopausal women being treated for oestrogen responsive breast cancer have shown that some of them are more likely than others to have a late recurrence of their cancer and might benefit from ten years of hormone therapy rather than five.

Prof Mitch Dowsett told the opening press conference at the European Breast Cancer Conference (EBCC-9) that his research had shown that women who had tumours that were negative for the human epidermal growth factor protein (HER2-) but which were very sensitive to the oestrogen hormone, had more than double the risk of their cancer recurring between five and ten years after surgery and five years of adjuvant hormone therapy.

"Our data suggest that these patients, who are those that appear to benefit most from the current standard five years of endocrine treatment, may also benefit from adjuvant hormone treatment that extends beyond that five years," said Prof Dowsett, who is Professor of Biochemical Endocrinology at The Institute of Cancer Research, London, UK, and Head of Biochemistry at The Royal Marsden NHS Foundation Trust, London. The work is a collaboration between his team and that of Professor Jack Cuzick at the Wolfson Institute of Preventive Medicine, Queen Mary University of London, UK.

The findings are the latest to come from the ATAC trial (Arimidex, Tamoxifen Alone or in Combination), a double-blinded phase III clinical trial that randomly assigned postmenopausal women with early, oestrogen receptor positive (ER+) breast cancer to receive the hormone therapies anastrozole or tamoxifen, or a combination of the two. [1]

Prof Dowsett and his colleagues at The Royal Marsden, The Institute of Cancer Research and Queen Mary University of London used data from the OncotypeDx 21-gene Recurrence Score that are not usually available from this test in order to analyse the genetic make-up and to predict the likelihood of cancer recurrin
'/>"/>

Contact: Emma Mason
wordmason@mac.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Genetic test could improve colon cancer screening
2. Sea anemone is genetically half animal, half plant
3. Fly meeting to spotlight research advances in genetics
4. Rice synthetic biologists shine light on genetic circuit analysis
5. Sudden cardiac death: Genetic disease ARVC more common than hitherto assumed
6. CHOP researcher finds more genetic signals linking weight and heart health risk factors
7. New tool to unlock genetics of grape-growing
8. Researchers at LSTM crack the genetic secret of mosquito resistance to DDT and ITNs
9. New study shows a genetic link between feeding behavior and animal dispersal
10. Compound improves cardiac function in mice with genetic heart defect, MU study finds
11. Genetics linked to children viewing high amounts of violent media
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... The most comprehensive assessment conducted by the Ocean ... out of 100 in overall health. In addition, ... Antarctic and the 15 ocean regions beyond national ... maintaining a healthy climate, safeguarding biodiversity and providing ... update of the index, a partnership led by ...
(Date:9/30/2014)... 30, 2014--Sea monkeys have captured the popular attention of ... observable life cycle -- sold as dehydrated eggs, these ... little more than a tank of salt water. ... Like other zooplankton, brine shrimp vertically migrate in large ... to the surface at night and retreating deeper during ...
(Date:9/30/2014)... and Howard Hughes Medical Institute investigator, and Margarita ... in the 2014 round of grants from the ... (Brain Research through Advancing Innovative Neurotechnologies) Initiative for ... 30, provides more than $3 million in funding ... The BRAIN Initiative, launched last year, is a ...
Breaking Biology News(10 mins):Rating the planet's oceans 2Rating the planet's oceans 3Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Salk scientists receive $3 million for BRAIN Initiative grant 2
... release is available in Spanish . , Agricultural ... wheat straw into ethanol "gold," and learning more about the ... production. At the ARS National Center for Agricultural ... conducted a 5-year study that examined whether wheat straw--a crop ...
... WASHINGTON, DC Fascinating advances across the spectrum ... be featured and explained through engaging table-top exhibits ... 16th Annual Exhibition and Reception. The exhibition/reception will ... Wednesday, April 14, in Rooms B338-340 of the ...
... old excuse, "I am only overweight because of my ... more evidence that the way our bodies digest and ... for every person. The budding discipline of metabolomics strives ... scientists and food chemists at the Technische Universitaet Muenchen ...
Cached Biology News:Cellulosic ethanol: Expanding options, identifying obstacles 2Science returns to Capitol Hill spotlight at April 14 exhibition 2Science returns to Capitol Hill spotlight at April 14 exhibition 3Science returns to Capitol Hill spotlight at April 14 exhibition 4Metabolic fingerprints offer fresh clues and a new path toward personalized medicine 2Metabolic fingerprints offer fresh clues and a new path toward personalized medicine 3
(Date:9/30/2014)... 30, 2014 BioHealth Innovation, Inc. ... biohealth innovations and increasing access to early-stage funding in ... venture capitalist, Tania Fernandez , Ph.D., has joined ... will be a member of the management team for ... to $50 million in seed and early-stage equity investments ...
(Date:9/30/2014)... CT (PRWEB) September 30, 2014 ... non-profit funder of Lyme disease research at universities, today ... researchers focused on the identification, treatment and cure for ... it had received the most applications in its history—over ... , “While we were pleased to receive so ...
(Date:9/30/2014)... New Jersey (PRWEB) September 30, 2014 ... it has been chosen by the Parenteral Drug ... (November 18 and 19, 2014) on container closure integrity ... container closure integrity test methods and philosophies detailed in ... – Integrity Evaluation. The course will span ...
(Date:9/29/2014)... Iraq and Afghanistan, more than 300,000 soldiers have returned ... by exposure to bomb blasts and in particular, ... traumatic brain injury can range from the mild, such ... in memory and cognition. , Since 2007, the ... and complexity of this problem, and has made significant ...
Breaking Biology Technology:Seasoned Life Sciences Venture Capitalist Tania Fernandez Joins BHI to Help Manage New BioHealth Gap Fund 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 2Lyme Research Alliance Awards Nearly $600,000 in New Grants 3Lyme Research Alliance Awards Nearly $600,000 in New Grants 4Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Modeling shockwaves through the brain 2Modeling shockwaves through the brain 3Modeling shockwaves through the brain 4
... skin tests at once with minimal patient discomfort, ... Unit announced today the launch of the ComforTen(TM) ... The device features ten,surgical steel 1.2mm lancet tips, ... ComforTen is the only 10-test, self-loading,surgical steel testing ...
... Nov. 9 Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ... commercializing proprietary product candidates principally,for use in the ... its,third quarter ended September 30, 2007 financial results ... 2007. Cadence management will host a conference ...
... Dose and Data from First Randomized ... N.J., Nov. 8 Bristol-Myers Squibb,Company (NYSE: BMY ... (FDA) has approved new labeling for SPRYCEL to include ... and safety and,efficacy data in a greater number of ...
Cached Biology Technology:HollisterStier Offers Comfort With New ComforTen(TM) Multiple Skin Testing Device 2HollisterStier Offers Comfort With New ComforTen(TM) Multiple Skin Testing Device 3Cadence Pharmaceuticals to Host Conference Call and Webcast to Discuss Third Quarter 2007 Financial Results 2FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 2FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 3FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 4FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 5FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 6FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 7FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 8FDA Approves New SPRYCEL(R) (Dasatinib) Product Labeling for Patients with Chronic-Phase CML 9
Mouse monoclonal [6G11] to Cytohesin 1 + 2 ( Abpromise for all tested applications)....
HNF-1 Purified Anti-Mouse, Anti-Rat, Anti-Rabbit, Anti-Human clone 2, Isotype Mouse IgG 1 , 50 µg Consult technical datasheet for details....
Recombinant Porcine IL-1 alpha/IL-1F1, CF...
... siRNA Custom Synthesis Service provides ... RNA to knockdown any gene. ... RNA base pairs with terminal ... or other lengths of your ...
Biology Products: