Navigation Links
Genetic test could improve colon cancer screening
Date:3/19/2014

A non-invasive test that includes detection of the genetic abnormalities related to cancer could significantly improve the effectiveness of colon cancer screening, according to research published by a team of scientists including David Ransohoff, MD, professor of medicine at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center member. The large-scale, cross-sectional study was published online today in The New England Journal of Medicine.

The study compared two different types of tests used for screening colorectal cancer: a non-invasive, multitarget stool test that includes DNA markers related to colon cancer along with a test that detects stool blood, versus a commercial fecal immunochemical test (FIT). While the FIT test detects hidden blood in the stool, a potential signal for cancer, the multitarget test also includes genetic mutations in the stool that are related to cancer. In the study of nearly 10,000 participants, the DNA test detected 92 percent of colon cancer, significantly more cancers compared to the 72 percent for the FIT test in asymptomatic participants at average risk for colorectal cancer.

The results from this study could impact screening rates, which remain frustratingly low in the U.S. despite the evidence of their effectiveness.

"Detection of 92 percent of colon cancer is extremely high for a non-invasive test, so that a negative test result means that no further evaluation, like colonoscopy, is needed at that time," said Ransohoff. "Having such a sensitive, non-invasive option could have an important effect on screening rates for colorectal cancer."

While the DNA test appears to be more sensitive than the FIT test, it did produce more false positive results, which would lead to colonoscopy. Further, the study did not address the question of how frequently non-invasive testing might be needed.

Colorectal cancer is the third leading cause of cancer-related d
'/>"/>

Contact: Katy Jones
katy_jones@unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. Will a genetic mutation cause trouble? Ask Spliceman
3. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
4. Perception and preference may have genetic link to obesity
5. A foot in the door to genetic information
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Epigenetics and epidemiology -- hip, hype and science
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. First complete full genetic map of promising energy crop
11. Genetic research develops tools for studying diseases, improving regenerative treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic test could improve colon cancer screening
(Date:5/18/2015)... GOTHENBURG, Sweden , May 18, 2015 ... touch fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from ... place from June until and including Q3 2015 and the ... Asia . Communicated order values for 2015 hereby amount ... revenues for Q1 2015 of 140 MSEK and a number ...
(Date:5/11/2015)... JOSE, Calif. , May 11, 2015 /PRNewswire/ ... developer of human interface solutions, today announced the ... Vice President and Chief Financial Officer, reporting to ... Ali replaces Synaptics, current Chief Financial Officer, ... December 2014. Mr. Ali brings ...
(Date:5/10/2015)... Fingerprint Cards (FPC) has received an order for ... World Peace Industrial Group (WPI), part of WPG Holdings. WPI ... . Deliveries are planned to take place during Q3 2015 ... China . The order value of 235 ... 1 000 MSEK for 2015.   Jörgen Lantto, acting ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2
... release is available in German . , ... the 2009 Charles Rodolphe Brupbacher Prize for Cancer Research. Nubia ... tumours such as cervical cancer through human papilloma viruses and ... smoking. The prize from the Charles Rodolphe Brupbacher Foundation has ...
... available in German . The use of ... risk that people may come into contact with it, and ... risk. However, radioactivity is not the only problem related to ... more dangerous to human health. Researchers are still looking for ...
... 2009 An international conference that will explore Darwin,s ... May 25-29. It is being organized to coincide with ... the Origin of Species, (and the 200th anniversaryspecifically, todayof ... of biology," says Ralph Pudritz, director of McMaster,s Origins ...
Cached Biology News:Brupbacher prize to Nubia Munoz and Sir Richard Peto 2Brupbacher prize to Nubia Munoz and Sir Richard Peto 3A pocketful of uranium 2
(Date:5/28/2015)... 27, 2015 Research and Markets( http://www.researchandmarkets.com/research/l9dqwt/animal_genetics ) ... Market by Products, by Testing services - Global Forecast ... The global animal genetics market is estimated to be ... a CAGR of 8-9% during the forecast period of ... driven by increasing animal protein consumption, increasing adoption of ...
(Date:5/28/2015)... 2015 Celsion Corporation (the "Company") (NASDAQ: ... from two institutional healthcare investors to purchase an aggregate ... in an at-the-market registered direct offering and a concurrent ... The Company entered into a definitive purchase agreement ... to sell an aggregate of 3,000,000 shares of its ...
(Date:5/28/2015)... BRUNSWICK, N.J. , May 28, 2015 /PRNewswire/ ... PDS0101, a cancer immunotherapy treatment targeting HPV-16, has ... Currently, pre-cervical cancer is treated ... offer a simple and effective non-surgical alternative. Results ... defense mechanisms (T-cells) to recognize, target, and kill ...
(Date:5/28/2015)... May 28, 2015 CD-adapco, the ... Engineering software, announced today it is joining the ... will provide state-of-the-art engineering simulation tools for analyzing ... expertise and experiences in analyzing particle flow that ... and advance the understanding of flow modeling solutions. ...
Breaking Biology Technology:Global Animal Genetics (Canine, Equine, Poultry, Porcine, Bovine, and Genetic Material) Market 2015 - Global Forecast to 2020 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $8 Million At-The-Market Registered Direct Offering 3PDS Biotechnology reports positive Phase I clinical trial results in proprietary HPV-Cancer Immunotherapy 2CD-adapco and PSRI Chartering New Course in Particle Flow Simulations 2
... Oct. 21 /PRNewswire-FirstCall/ - SemBioSys Genetics Inc. ("SemBioSys") ... entered into a definitive agreement to acquire all ... Specialty Ingredients Inc. ("Botaneco") held by SemBioSys and ... an initial 9.48 percent shareholding in Advitech, in ...
... BEIJING, Oct. 20, 2009 Monsanto Company and Huazhong ... the development of novel traits such as higher yield, ... and advance certain technologies developed by Professor Qifa Zhang,s ... "We,re excited to be working with a prominent research ...
... 20 NuVasive, Inc. (Nasdaq: NUVA ... minimally disruptive surgical treatments for the spine, announced today financial ... reported third quarter revenue of $94.9 million, a 41.8% increase ... a 7.3% increase over the $88.5 million for the second ...
Cached Biology Technology:SemBioSys provides an update on Botaneco 2SemBioSys provides an update on Botaneco 3SemBioSys provides an update on Botaneco 4Monsanto and Huazhong Agricultural University Enter Into Collaboration Focusing on Development of Plant Biotechnology 2Monsanto and Huazhong Agricultural University Enter Into Collaboration Focusing on Development of Plant Biotechnology 3NuVasive Reports Third Quarter 2009 Financial Results 2NuVasive Reports Third Quarter 2009 Financial Results 3NuVasive Reports Third Quarter 2009 Financial Results 4NuVasive Reports Third Quarter 2009 Financial Results 5NuVasive Reports Third Quarter 2009 Financial Results 6NuVasive Reports Third Quarter 2009 Financial Results 7NuVasive Reports Third Quarter 2009 Financial Results 8NuVasive Reports Third Quarter 2009 Financial Results 9NuVasive Reports Third Quarter 2009 Financial Results 10NuVasive Reports Third Quarter 2009 Financial Results 11NuVasive Reports Third Quarter 2009 Financial Results 12
... the consumable measurement plate for ... individually controlled measurement sites. Each ... liquid flow channel system that ... solution and compound applications necessary ...
... capable of dynamic scheduling, is designed to ... automation workcells easy for lab personnel, yet ... • Users create methods by ... can build a flowchart, you can write ...
... research demands continue to grow, the need ... information has become necessary, especially when discerning ... The innovative C1si Confocal Microscope System gives ... spectral capability not available in conventional confocal ...
... provides complete components including positive and ... of DNA fragmentation in cultured cells ... BrdU in the procedure provides greater ... Results can be analyzed by fluorescence ...
Biology Products: