Navigation Links
Genetic test could improve colon cancer screening
Date:3/19/2014

A non-invasive test that includes detection of the genetic abnormalities related to cancer could significantly improve the effectiveness of colon cancer screening, according to research published by a team of scientists including David Ransohoff, MD, professor of medicine at the UNC School of Medicine and UNC Lineberger Comprehensive Cancer Center member. The large-scale, cross-sectional study was published online today in The New England Journal of Medicine.

The study compared two different types of tests used for screening colorectal cancer: a non-invasive, multitarget stool test that includes DNA markers related to colon cancer along with a test that detects stool blood, versus a commercial fecal immunochemical test (FIT). While the FIT test detects hidden blood in the stool, a potential signal for cancer, the multitarget test also includes genetic mutations in the stool that are related to cancer. In the study of nearly 10,000 participants, the DNA test detected 92 percent of colon cancer, significantly more cancers compared to the 72 percent for the FIT test in asymptomatic participants at average risk for colorectal cancer.

The results from this study could impact screening rates, which remain frustratingly low in the U.S. despite the evidence of their effectiveness.

"Detection of 92 percent of colon cancer is extremely high for a non-invasive test, so that a negative test result means that no further evaluation, like colonoscopy, is needed at that time," said Ransohoff. "Having such a sensitive, non-invasive option could have an important effect on screening rates for colorectal cancer."

While the DNA test appears to be more sensitive than the FIT test, it did produce more false positive results, which would lead to colonoscopy. Further, the study did not address the question of how frequently non-invasive testing might be needed.

Colorectal cancer is the third leading cause of cancer-related deaths in the United States and is expected to cause over 50,000 deaths in 2014, according to the American Cancer Society.


'/>"/>
Contact: Katy Jones
katy_jones@unc.edu
919-962-3405
University of North Carolina Health Care
Source:Eurekalert  

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. Will a genetic mutation cause trouble? Ask Spliceman
3. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
4. Perception and preference may have genetic link to obesity
5. A foot in the door to genetic information
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Epigenetics and epidemiology -- hip, hype and science
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. First complete full genetic map of promising energy crop
11. Genetic research develops tools for studying diseases, improving regenerative treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic test could improve colon cancer screening
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by ... Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to ... USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... Yorba Linda, Ca (PRWEB) , ... April 20, ... ... Virtual University Virtual Event , this new webinar will explore challenging patient cases ... are admitted to the hospital, there may be a need for bridging parental ...
(Date:4/20/2017)... BARBARA, CALIFORNIA (PRWEB) , ... April 20, 2017 , ... ... optimization firm for the life sciences and healthcare industries, is pleased to announce ... the new established USDM subsidiary “USDM Europe GmbH” based in Germany. , Braemer ...
(Date:4/20/2017)... , April 20, 2017 /PRNewswire/ - Prometic Life Sciences Inc. ... new results at the International Liver Congress ("ILC") 2017 of ... in Amsterdam on the positive effects ... mouse model of obesity and metabolic syndrome. ... According to Dr. Lyne Gagnon, Vice-President of ...
(Date:4/20/2017)... ... April 20, 2017 , ... Open Therapeutics and the ... sharing and commercialization model. , The Center for Advancing Innovation helps institutions maximize ... effort is bringing the IP to the attention of the entrepreneurial community and ...
Breaking Biology Technology: