Navigation Links
Genetic study shows direct link between vitamin D and MS susceptibility 'gene'
Date:2/5/2009

/p>

"In people with the DRB1 variant associated with MS, it seems that vitamin D may play a critical role," says co-author Dr Julian Knight. "If too little of the vitamin is available, the gene may not function properly."

"We have known for a long time that genes and environment determine MS risk," says Professor George Ebers, University of Oxford. "Here we show that the main environmental risk candidate vitamin D and the main gene region are directly linked and interact."

Professor Ebers and colleagues believe that vitamin D deficiency in mothers or even in a previous generation may lead to altered expression of DRB1*1501 in offspring.

The finding that the environment interacts directly with the background genetics of MS complements research recently published in Human Molecular Genetics by Professor Ebers's group. There, they showed that environment changes to the same gene region can increase the risk of developing MS even further and can be inherited. These so-called "epigenetic effects" are being seen as increasingly important by scientists and there may be ways in which the effects reported in these two papers are related.

"Epigenetics will have important implications, not only for MS, but for other common diseases," says Professor Ebers. "For mothers, taking care of their health during their reproductive years may have beneficial effects on the health of their future children or even grandchildren."

The authors hypothesise that this gene-environment interaction may affect the ability of the thymus, a key component of the immune system, to perform its regular tasks. The thymus produces an army of T cells, which identify invading pathogens, such as bacteria and viruses, and attack and destroy them. There are millions of different T cells, each designed to recognise a specific pathogen, but there is a risk that one type might mistakenly identify one of the body's own cells or proteins.
'/>"/>

Contact: Catriona Silvey
press@plos.org
Public Library of Science
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... votes for independence later this week, its Government could ... that fracking is necessary, research has revealed. , The ... public perception of shale gas extraction in the UK ... north of the border are the least supportive of ... in the University,s School of Geography, said: "The clear ...
(Date:9/16/2014)... waters of Southeast Alaska to the white sand beaches ... and tourist towns, coastal residents around the U.S. share ... along political lines. That,s a primary finding of a ... this month in the journal Society & Natural ... differences from place to place to place. Each environment ...
(Date:9/16/2014)... million gallons of oil into Alaska,s Prince William Sound. ... in the Gulf of Mexico in 2010. According to ... Research , news coverage of environmental disasters serves to ... the way fossil fuels are used. , "We found ... events helped to resolve many of the cultural anxieties ...
Breaking Biology News(10 mins):Scottish people most sceptical on fracking, survey shows 2Scottish people most sceptical on fracking, survey shows 3Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3Exxon Valdez 2014: Does media coverage of manmade disasters contribute to consumer complacency? 2
... a mission to sniff out trouble and display their ... of Naval Research (ONR)-hosted "Top Dog Demo 2012." ... move through the battle space," said Lisa Albuquerque, program ... ONR,s Expeditionary Warfare and Combating Terrorism department. "Marines can ...
... high speed rail lines in China will be the topic ... Liu takes the stage at the annual 91st Transportation Research ... gathering in transportation, if not all of engineering, with upwards ... an expert in high speed rail lines and other transportation ...
... EAST LANSING, Mich. -- A receptor found on blood platelets ... questioned may in fact be fruitful in drug testing, according ... team led by Dana Spence of MSU,s Department of Chemistry ... known as P2X1. By creating a new, simple method to ...
Cached Biology News:Marine's best friend shows explosive-detecting capabilities 2NJIT high speed rail expert to address DC conference next week 2NJIT high speed rail expert to address DC conference next week 3Chemists unlock potential target for drug development 2
(Date:9/16/2014)... September 16, 2014 Pharma ... to position themselves for their 89th year ... and encoding, Pharma Packaging Solutions is preparing ... and software and new procedures. Establishing training ... Manufacturing Practices (cGMP), Pharma Packaging Solutions will ...
(Date:9/16/2014)... Sept. 16, 2014  Ascendis Pharma A/S, a ... to address significant unmet medical needs, today announced ... pediatric study to evaluate once-weekly TransCon Growth Hormone ... The full interim results will be presented at ... IGF Society, being held October 15-18, 2014, in ...
(Date:9/16/2014)... Australia (PRWEB) September 16, 2014 RENU 28, ... Signaling molecules, became available for purchase in Australia and ... a nationwide tour beginning September 16th. The tour will make ... the 17th, Bundaberg on the 18th, Sydney on the 20th, ... market in Australia and New Zealand and to educate people ...
(Date:9/15/2014)... , Sept. 15, 2014 EnGeneIC, ... revolutionizing the treatment of cancer through the targeted ... announced that, together with the Asbestos Disease Research ... Institute New South Wales (NSW) Premier,s Award for ... recipients are the hospitals that will be involved ...
Breaking Biology Technology:Adding Serialization Capabilities and Expanded Capacity, Pharma Packaging Solutions Is Preparing for 89th Year of Business 2Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Global Wellness Company Hosts ASEA Australia Tour September 16-22 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 2EnGeneIC Named a Recipient of the Cancer Institute NSW Premier's Award for Excellence in Translational Cancer Research 3
... DENVER, Nov. 18, 2010 BioSpace ... Campaign this morning, showcasing biotechnological, pharmaceutical ... States and Canada. (Logo: http://photos.prnewswire.com/prnh/20040907/CLTU006LOGO) ... campaign promotes life science organizations within Oregon, ...
... Inc. (OTCBB: GNLK ), a leading consumer genomics biotech company, today ... Highlights: Gross Profit Margin ... for the second year in a row GeneLink announces Private ... GeneLink,s CEO stated, "The third quarter of 2010 continues to reflect ...
... Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... var shortURL = ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are ...
Cached Biology Technology:BioSpace Highlights the Northwest's Growing Life Science Region 2GeneLink Reports Third Quarter Results 2Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 2Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 3Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 4Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 5Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 6Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 7Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 8Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 9Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 10Aeterna Zentaris Presents Positive Phase 2 Efficacy and Safety Data for AEZS-108 in Advanced Endometrial Cancer at ENA Meeting in Berlin, Germany 11
Presenilin-1, N-terminus....
Request Info...
Human DEP-1/CD148 Fluorescein MAb (Clone 143-41) Protein Family: Granulocyte Markers, Monocyte Markers, Phosphatases & Regulators, Other Dendritic Cell Molecules...
An excellent carbonyl-reactive FRET quencher paired with Trp or Tyr. Minimum Purity: 95%. Abs(max): ~350 nm; Em(max): none. Solvent System:DMSO or DMF....
Biology Products: