Navigation Links
Genetic studies of human evolution win researcher 2011 Gani Medal
Date:12/8/2010

Major advances in our understanding of human evolution have seen Walter and Eliza Hall Institute researcher Dr Alicia Oshlack awarded the 2011 Gani Medal for Human Genetics by the Australian Academy of Science.

The Gani Medal recognises distinguished research in human genetics by early career researchers and honours the contribution to genetics of the late Ruth Stephens Gani.

Dr Oshlack, a senior research officer in the institute's Bioinformatics division, has made new strides in understanding the genetic basis of human evolution by natural selection. She has compared gene expression levels between humans and apes to show that transcription factors, which control when genes are switched on or off, evolved rapidly in humans.

"I feel very honoured and excited to be awarded the Ruth Gani Medal," said Dr Oshlack. "It's an exciting time in genetics the past three years have brought a revolution in the way we do genetics and exponentially increased the possibilities for what we can learn about the genome.

"High-throughput genomic technologies are underpinning the new wave of biology research, giving us amazing new insights into how cells develop and function, and the changes that lead to disease," Dr Oshlack said. "My research is now more focussed on improving our understanding of gene expression and regulation essentially what leads to particular genes being switched on, or expressed, and the factors that control or 'regulate' the switching on or off of genes."

She is currently working on methods that will help understand how stem cells develop and differentiate into different cell types such as skin, lung or blood cells and the changes that occur in diseased cells, such as cancer.

"One aspect of our work is studying epigenetics the factors that control when and how genes are expressed," Dr Oshlack said. "The DNA in all the cells in your body is exactly the same, so how do all these different cell types, with very different functions, develop from the same blueprint?"

Dr Oshlack said her methodologies for investigating gene expression and control could be applied to many aspects of human biology and medical genetics. She is pioneering analysis of new DNA sequencing technology for studying gene expression and has also been involved in projects to uncover the genetic causes of human disease and changes in gene expression and control in different cancers.

"The biggest challenge is integrating the information on how genes are expressed and controlled to make new discoveries about the normal function of cells and the changes that lead to disease," Dr Oshlack said.

Institute director Professor Doug Hilton said the methodologies Dr Oshlack has developed have the potential to reveal unprecedented detail about gene expression and control.

"In her young career, Alicia has made a major contribution in the field of gene expression in human genetics and evolution," Professor Hilton said. "Her prolific research in methodology and designing and interpreting genomics data will lead to a greater understanding of gene control in human disease."

Dr Oshlack is the second Walter and Eliza Hall Institute researcher to be awarded the Gani Medal, with Dr Marnie Blewitt receiving the prize in 2008.


'/>"/>

Contact: Liz Williams
willliams@wehi.edu.au
61-393-452-928
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Rare genetic disorder gives clues to autism, epilepsy, mental retardation
2. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
3. Study finds genetic variant plays role in cleft lip
4. Genetic finding implicates innate immune system in major cause of blindness
5. American College of Medical Genetics receives $13.5M NIH contract
6. Clue to genetic cause of fatal birth defect
7. Can genetic information be controlled by light?
8. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
9. Modern genetics vs. ancient frog-killing fungus
10. Genetic based human diseases are an ancient evolutionary legacy
11. Genetic evidence for avian influenza movement from Asia to North America via wild birds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic studies of human evolution win researcher 2011 Gani Medal
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:3/30/2017)... The research team of The Hong Kong ... identification by adopting ground breaking 3D fingerprint minutiae recovery and matching ... and accuracy for use in identification, crime investigation, immigration control, security ... ... A research team led by ...
(Date:3/27/2017)... , March 27, 2017  Catholic Health Services ... Management Systems Society (HIMSS) Analytics for achieving Stage ... Model sm . In addition, CHS previously earned ... hospitals using an electronic medical record (EMR). ... high level of EMR usage in an outpatient ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... President Andi Purple announced Dr. Suneel I. Sheikh, the co-founder, CEO and chief ... ), Inc. has been selected for membership in ARCS Alumni Hall of ...
(Date:10/11/2017)... ... ... is a basic first aid supply for any work environment, but most personal eye wash ... if a dangerous substance enters both eyes? It’s one less decision, and likely quicker response ... piece. , “Whether its dirt and debris, or an acid or alkali, getting anything in ...
(Date:10/11/2017)... ... 2017 , ... Proscia Inc ., a data solutions ... “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, Managing ... how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
Breaking Biology Technology: