Navigation Links
Genetic signature identified for RSV, the leading cause of infant hospitalizations worldwide
Date:11/14/2013

SV, genes involved in the function of interferon and neutrophilskey components of the innate immune systemwere activated, while genes that regulate T and B cells in the adaptive immune system were suppressed. The researchers plugged this biosignature into an algorithm used to compare the expression of specific genes between patients and healthy controls. The formula yields a score called "molecular distance to health." In the end, Dr. Mejias and her team were able to link specific scores to disease severity. The scores were so precise, in fact, that researchers could tell from the scores how many days RSV-infected infants had required hospitalization or supplemental oxygen.

"We showed that screening RNA profiles is a useful tool from the diagnostic point of view, as it allowed differentiation from influenza and rhinovirus infections with great accuracy," Dr. Mejias says. "It also helps us better understand the pathogenesis of this infection and, more important, to objectively assess disease severity in these patients."

Knowing the molecular distance to health score for RSV patients could soon have a direct application in the clinical setting, Dr. Mejias adds. Tools designed to calculate such scores in emergency roomsthe first stop for many patients with RSVand even in pediatricians' offices are currently under development.

"These novel and affordable tools will have a much faster turn-around time that could facilitate the application of RNA profiles in 'real time' in the clinical setting," says Dr. Mejias, who also is an assistant professor of pediatrics at The Ohio State University College of Medicine. "It may help triage patients when they first present to the emergency room or pediatric office, but it could also be useful for monitoring clinical changes during the course of the disease, with the ultimate goal of predicting clinical outcomes."

The findings also give researchers a better picture of just how the immune system r
'/>"/>

Contact: Gina Bericchia
Gina.Bericchia@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Nurture impacts nature: Experiences leave genetic mark on brain, behavior
2. Cause of genetic disorder found in dark matter of DNA
3. Genetic variation increases risk of kidney disease progression in African-Americans
4. Genetic aberration paves the way for new treatment of cancer disease
5. Genetic study proves Israels wild boars originated in Europe
6. Dolphin genetic study provides revelations
7. Genetic rarity rules in wild guppy population, study finds
8. GenSeq: Updated nomenclature for genetic sequences to solve taxonomic determination issues
9. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
10. HIV -- Geneticists map human resistance to AIDS
11. Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... discoveries in basic and clinical research and technological ... a complex offensive spanning multiple fronts. , Work ... could help find new and more selective therapies ... targets a specific enzyme overexpressed in certain cancersand ... brain tumours. , Chemistry professor Christopher Cairo and ...
(Date:8/22/2014)... to purchase fuel cell cars from Toyota and other ... cars will run on hydrogen made from natural gas, ... Now scientists at Stanford University have developed a low-cost, ... produce hydrogen by water electrolysis. The battery sends ... water into hydrogen and oxygen gas. Unlike other water ...
(Date:8/21/2014)... , Aug. 21, 2014 Nxt-ID, Inc. ... growing mobile commerce market, announced today that its shares ... stock to be issued in its proposed underwritten public ... for listing on The Nasdaq Capital Market, subject to ... common stock and warrants, and will trade under the ...
Breaking Biology News(10 mins):New enzyme targets for selective cancer therapies 2New enzyme targets for selective cancer therapies 3Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3
... The Tyler Prize for Environmental Achievement today named Diana H. ... 2013 Tyler Prize for her research documenting and exploring the ... from more than 20 years in Antarctica,s deserts, to the ... has explored the dynamics of species like nematodes, small worm-like ...
... Swarming is the spontaneous organised motion of a large number ... colonies, slime moulds and groups of insects to shoals of ... Romenskyy and Vladimir Lobaskin from University College Dublin, Ireland, have ... just published in EPJ B . Ultimately, this could ...
... spinoff of research at Case Western Reserve University, has ... to develop a medical device for bladder control. ... function lost due to injury or illness. Patients with ... likely to be the first to benefit from the ...
Cached Biology News:Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 2Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 3Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 4Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize 5CWRU spinoff ConservoCare gets licensing options to develop medical device for bladder control 2CWRU spinoff ConservoCare gets licensing options to develop medical device for bladder control 3
(Date:8/22/2014)... In a study published today (August 22nd), in ... at the Champalimaud Neuroscience Programme establish the effect ... combination of advanced genetic and optical techniques., "Serotonin ... in a wide range of brain functions, from ... regulation of complex emotional behaviours, This neurotransmitter is ...
(Date:8/22/2014)... 2014 The Global and China Diabetes ... the current state of the Diabetes Drug industry in ... overview of the industry, including definitions, applications and industry ... analysis are provided with a focus on history, developments, ... between the international and Chinese situation is also offered. ...
(Date:8/22/2014)... Nerium International, the go-to, buzzworthy skincare ... again. Nerium will showcase its signature NeriumAD® Age-Defying ... Cream to Hollywood’s elite at the official Giving ... Primetime Emmy® Awards. , Developed from cutting-edge research ... show that NeriumAD night cream dramatically reduces the ...
(Date:8/21/2014)... PA & Rockville, MD (PRWEB) August 21, 2014 ... (ITI) is making progress in its development of ... to Japanese red cedar pollen. Phase IC studies began ... a real solution to hay fever. , The Japanese ... over 35 million people in Japan. Mountain Cedar pollen ...
Breaking Biology Technology:From happiness to pain: Understanding serotonin's function 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4
... Wis. - For the first time in the team's history, ... ranked first in the nation, giving Wisconsin fans just one more ... and I know the team will enjoy tremendous support from everyone ... University of Wisconsin System shouldn't begin or end with the ...
... Wis. - Paul Hager admits the technology associated ... proprietary ways to address its flaws and transform it ... early-stage Madison business called VoVison , has ambitious ... three differentiating features: a hosted solution, plus self-correction and ...
... since DEMO 2007, I've had the chance to play a ... Jaman.com . Launched at the conference, Jaman.com offers a growing ... at prices that average about $6 per film. , ,While ... the Jaman.com experience is the downloadable player, a desktop application ...
Cached Biology Technology:Fueling our economy with the University of Wisconsin 2Fueling our economy with the University of Wisconsin 3Fueling our economy with the University of Wisconsin 4Tech upstart VoVision could disrupt the voice-recognition market 2Tech upstart VoVision could disrupt the voice-recognition market 3Tech upstart VoVision could disrupt the voice-recognition market 4We're "Jaman": Purpose-driven browsers drive next wave of Web applications 2We're "Jaman": Purpose-driven browsers drive next wave of Web applications 3
...
Recombinant Feline IFN-alpha...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
Biology Products: