Navigation Links
Genetic septet in control of blood platelet clotting
Date:6/22/2010

In what is believed to be the largest review of the human genetic code to determine why some people's blood platelets are more likely to clump faster than others, scientists at Johns Hopkins and in Boston have found a septet of overactive genes, which they say likely control that bodily function.

"Our results give us a clear set of new molecular targets, the proteins produced from these genes, to develop tests that could help us identify people more at risk for blood clots and for whom certain blood-thinning drugs may work best or not," says co-senior study investigator and cardiologist Lewis Becker, M.D.

"We can even look toward testing new treatments that may speed up how the body fights infection or recovers from wounds," says Becker, a professor at the Johns Hopkins University School of Medicine.

Platelets are key to fighting infection and sealing wounds and, adversely, can speed up cardiovascular diseases that can lead to potentially fatal heart attacks or strokes.

Reporting in the issue of Nature Genetics online June 7, researchers tested the platelet "stickiness" in blood samples from some 5,000 American men and women and compared the results to some 2.5 million single possible changes in the human genetic code to see which genes stood out across the entire group as speeding up or slowing down platelet clumping. Study participants included both whites and blacks with no previously known chronic health problems, representing what researchers say is "a solid cross-section of American society."

Seven genes were found on their own to be hugely significant in affecting how fast or how long it took for platelets to stick together or how many platelets would clump. (The seven were more than 500 million times more likely than other genes to impact clumping, whereas the next most influential genes, a set of 15, were found to be 10,000 times more likely to affect clumping function.)

According to Becker,
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetically modified cell procedure may prove useful in treating kidney failure
2. Freely available data supporting next generation of human genetic research
3. Should the results of individual genetic studies be disclosed to participants?
4. Small genetic variant can predict response to hepatitis C treatment
5. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
6. New microbial genetic system dissects biomass to biofuel conversion
7. Autism genome project identifies genetic variants that may make people susceptible to disorder
8. Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
9. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
10. Genetics Society of America to host Model Organisms to Human Biology Meeting, June 12-15, 2010
11. AMP cautions consumers about direct access genetic testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... 17, 2015 Increasing ... technological advancement to drive biometric systems market in ...   According to a recently released ... &  Opportunities, 2020 ", biometric systems market in ... growth at CAGR of over 22% through 2020. ...
(Date:4/14/2015)... , April 14, 2015 NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... nominated for the 2015 New York Design Awards under ... Design100, New York City Design Awards are part of ... on over 2,500 ratings from the marketplace, industry and ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... Holdings, Inc. (NYSE MKT: ONVO) ("Organovo"), a three-dimensional biology company ... to present at the 24th Annual Oppenheimer Healthcare Conference, which ... December 10-11, 2013. Organovo,s Chairman and Chief ... Wednesday, December 11, at 2:45pm ET. The objective ...
... soak up a dangerous pore-forming toxin produced by MRSA ... safe and effective vaccine against this toxin. This "nanosponge ... the adverse effects of the alpha-haemolysin toxin from MRSAboth ... the University of California, San Diego described the safety ...
... proteins just beneath its surface until it is trapped as ... hits of energy eventually power the growth and movement of ... life. The three clumps of protein a light-harvesting ... look like random scrawls in illustrations but this is misleading. ...
Cached Biology News:Organovo to Present at the 24th Annual Oppenheimer Healthcare Conference 2'Nanosponge vaccine' fights MRSA toxins 2'Nanosponge vaccine' fights MRSA toxins 3'Nanosponge vaccine' fights MRSA toxins 4Scientists stitch up photosynthetic megacomplex 2Scientists stitch up photosynthetic megacomplex 3
(Date:6/2/2015)... ST. LOUIS , June 2, 2015 /PRNewswire/ ... leading Life Science and Technology company, announced today ... XCell Science to launch genetically engineered human ... to advance the research of neurological diseases. These ... portfolio, provide unique and versatile tools for the ...
(Date:6/2/2015)... 02, 2015 Through rare discovery of ... Yancy Corporation is enabling World Scientists to actually ... biological sample, displaying the full nature (position, shape, size, ... , Jeff Porter, Co-Founder of the Yancy Corporation, says, ... – rare. They come once in a lifetime, if ...
(Date:6/1/2015)... YORK , June 1, 2015  Turing ... researcher  Eliseo Oreste Salinas , MD, MSc,  has ... development. Dr. Salinas, who holds a ... pharmacology, brings a record of significant accomplishments in ... psychiatry.  Dr. Salinas has played a ...
(Date:6/1/2015)... YORK , June 1, 2015 ... by the fermentation of sugar or cellulose. Bio-alcohols are ... can be used as a replacement for gasoline in ... grow at a CAGR of 9 percent over the ... The global bio-alcohols market can be segmented into five: ...
Breaking Biology Technology:Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 2Sigma-Aldrich to Launch XCell Science Genetically Engineered iPSC-Derived Neural Disease Cells 3Scientists Eying Rare Discovery Of New Physics & Light Microscope Technology 2Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 2Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 3Global Bio-alcohols Market 2015-2019 2
... ... ... var shortURL = ... need to grab the first one. for (var r in data.results) { first_result = data.results[r]; break; } for (var ...
... 2010 Kendle (Nasdaq: KNDL ), a ... business awards for the third quarter of 2010 of ... quarter moderated significantly to $10.4 million or 1.3 percent ... in a net book-to-bill of 1.5. New business authorizations ...
... DST Health Solutions, LLC, today launched new versions ... Advance, PowerMHC, PowerMHS and PowerSTEPP. The platforms now support ... & Medicaid Services (CMS). This change—from Version 4010/4010A to ... effective Jan. 1, 2012, as designated by CMS. ...
Cached Biology Technology:Oncothyreon Reports Third Quarter 2010 Financial Results 2Oncothyreon Reports Third Quarter 2010 Financial Results 3Oncothyreon Reports Third Quarter 2010 Financial Results 4Oncothyreon Reports Third Quarter 2010 Financial Results 5Oncothyreon Reports Third Quarter 2010 Financial Results 6Oncothyreon Reports Third Quarter 2010 Financial Results 7Oncothyreon Reports Third Quarter 2010 Financial Results 8Oncothyreon Reports Third Quarter 2010 Financial Results 9Oncothyreon Reports Third Quarter 2010 Financial Results 10Oncothyreon Reports Third Quarter 2010 Financial Results 11Kendle Announces Third Quarter 2010 Results 2Kendle Announces Third Quarter 2010 Results 3Kendle Announces Third Quarter 2010 Results 4Kendle Announces Third Quarter 2010 Results 5Kendle Announces Third Quarter 2010 Results 6HIPAA 5010 Ready: DST Health Solutions Launches Upgrades of Amisys Advance, PowerMHS, PowerMHC and PowerSTEPP 2HIPAA 5010 Ready: DST Health Solutions Launches Upgrades of Amisys Advance, PowerMHS, PowerMHC and PowerSTEPP 3
Request Info...
Request Info...
Request Info...
... Ambion's custom siRNA service provides the ... gene silencing research. Custom siRNAs can be ... 19-21 base target sequence, or by providing ... check out Ambion's Silencer Validated and Silencer ...
Biology Products: