Navigation Links
Genetic septet in control of blood platelet clotting
Date:6/22/2010

In what is believed to be the largest review of the human genetic code to determine why some people's blood platelets are more likely to clump faster than others, scientists at Johns Hopkins and in Boston have found a septet of overactive genes, which they say likely control that bodily function.

"Our results give us a clear set of new molecular targets, the proteins produced from these genes, to develop tests that could help us identify people more at risk for blood clots and for whom certain blood-thinning drugs may work best or not," says co-senior study investigator and cardiologist Lewis Becker, M.D.

"We can even look toward testing new treatments that may speed up how the body fights infection or recovers from wounds," says Becker, a professor at the Johns Hopkins University School of Medicine.

Platelets are key to fighting infection and sealing wounds and, adversely, can speed up cardiovascular diseases that can lead to potentially fatal heart attacks or strokes.

Reporting in the issue of Nature Genetics online June 7, researchers tested the platelet "stickiness" in blood samples from some 5,000 American men and women and compared the results to some 2.5 million single possible changes in the human genetic code to see which genes stood out across the entire group as speeding up or slowing down platelet clumping. Study participants included both whites and blacks with no previously known chronic health problems, representing what researchers say is "a solid cross-section of American society."

Seven genes were found on their own to be hugely significant in affecting how fast or how long it took for platelets to stick together or how many platelets would clump. (The seven were more than 500 million times more likely than other genes to impact clumping, whereas the next most influential genes, a set of 15, were found to be 10,000 times more likely to affect clumping function.)

According to Becker,
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genetically modified cell procedure may prove useful in treating kidney failure
2. Freely available data supporting next generation of human genetic research
3. Should the results of individual genetic studies be disclosed to participants?
4. Small genetic variant can predict response to hepatitis C treatment
5. Genetics Society of America to host 2010 Yeast Genetics & Molecular Biology Meeting
6. New microbial genetic system dissects biomass to biofuel conversion
7. Autism genome project identifies genetic variants that may make people susceptible to disorder
8. Study finds epigenetic similarities between Wilms tumor cells and normal kidney stem cells
9. UT Southwestern researchers use novel sperm stem-cell technique to produce genetically modified rats
10. Genetics Society of America to host Model Organisms to Human Biology Meeting, June 12-15, 2010
11. AMP cautions consumers about direct access genetic testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/25/2015)... Ark. , Feb. 25, 2015  ABC ... and billing in the Health and Fitness Industry, ... well as to MYiCLUBonline.  The latest upgrade includes ... the inclusion of cardless check-in via Identity One ... the first time through interactive displays at the ...
(Date:2/19/2015)... , Feb .19, 2015 Research and ... the addition of the "Military Electro-Optical / ... Sensor Technology, by Platform - Forecast to 2020" ... The military electro-optical/infrared systems market is expected to ... CAGR of 7.71%. This report segments ...
(Date:2/11/2015)... 11, 2015 According ... Control Market by Product (Cards and Readers, Biometrics, Controllers, ... Government, Industrial, Healthcare, Education) and By Geography - Global Forecast and ... the Access Control Market is expected to ... a CAGR of 10.6% between 2014 and ...
Breaking Biology News(10 mins):ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4
... 60m investment in UK universities to help our ... from their research, improve industrial collaboration, and foster ... Global Entrepreneurship Week, at a visit to the ... an SME which uses advanced urban modelling techniques ...
... ARBOR, Mich. Are you good at coping when life ... help others without expecting anything in return? Those ... popularity contest. According to new University of Michigan-led neuroscience research, ... pain relief from a placebo a fake medicine. ...
... 2012Individuals who do not obtain recommended intake levels of ... to achieve optimal bone health, an expert panel concludes. ... of Advances in Nutrition , a journal that ... illustrates the central role of nutrition in the promotion ...
Cached Biology News:£60 million boost for science innovation 2£60 million boost for science innovation 3When the going gets tough, the tough get... more relief from a placebo? 2When the going gets tough, the tough get... more relief from a placebo? 3Calcium supplements remain a valuable tool for maintaining bone health 2Calcium supplements remain a valuable tool for maintaining bone health 3
(Date:3/5/2015)... 05, 2015 Research and Markets ( ... "Mature Biotech Outlook 2015: New Therapy Ventures Pave the ... All biotech companies - Gilead (GILD), Amgen ... year, have given a positive return and hence increased ... able to select therapy/niche indication where the high treatment ...
(Date:3/4/2015)... -- PDL BioPharma, Inc. (PDL) (NASDAQ: PDLI ) ... , 3.75% Convertible Senior Notes due May 1, 2015 ... $1,000 principal amount or approximately $5.72 per share, effective March 3, ... is adjusted in connection with the regular quarterly dividend of ... who own shares of PDL on March 5, 2015, the record ...
(Date:3/4/2015)... Research and Markets ( http://www.researchandmarkets.com/research/nqxxt3/biomarkers ... new report "Biomarkers - Technologies, Markets and ... This report follows the broad definition of a ... measured and evaluated as an indicator of normal ... responses to a therapeutic intervention. Tests based on ...
(Date:3/4/2015)... , March 4, 2015 AcelRx ... specialty pharmaceutical company focused on the development and ... acute and breakthrough pain, today announced that it ... results after market close on Monday, March 9th, ... call at 4:30 p.m. Eastern Time (1:30 p.m. ...
Breaking Biology Technology:Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3PDL BioPharma Announces Conversion Rate Adjustment for Convertible Note 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 2AcelRx Pharmaceuticals to Hold Annual 2014 Financial Results Conference Call and Webcast on Monday, March 9th, 2015 3
... Results, SAN DIEGO, March 19 Imagenetix, ... of Research and,Development, Dr. Robert Hesslink, presented basic ... of Celadrin(R). Dr. Hesslink,outlined the pathway before an ... 2008 meeting in Paris, France. The meeting was,sponsored ...
... Scientific Officer Dr. David Gelfand to Deliver ... WaferGen,Biosystems, Inc. (OTC Bulletin Board: WGBS), ... cell biology and stem cell,research systems, today ... will deliver a keynote speech at the ...
... SOPHIA ANTIPOLIS, France, March 19 NicOx ... signed an agreement with the fine,chemical company ... of,naproxcinod drug substance (or active pharmaceutical ingredient, ... the first compound,in the COX-Inhibiting Nitric Oxide-Donating ...
Cached Biology Technology:Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France 2Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France 3WaferGen to Present at the Cambridge Health Institute's Fifth Annual Molecular Diagnostics Partnerships in Personalized Medicine Conference 2WaferGen to Present at the Cambridge Health Institute's Fifth Annual Molecular Diagnostics Partnerships in Personalized Medicine Conference 3NicOx Signs Agreement for the Commercial Manufacture of Naproxcinod Drug Substance 2NicOx Signs Agreement for the Commercial Manufacture of Naproxcinod Drug Substance 3NicOx Signs Agreement for the Commercial Manufacture of Naproxcinod Drug Substance 4
The antibody recognizes the peptide sequence ESESQGPK (aa 441-448) of human class III beta-tubulin specific for neurones....
Unique enzyme blend containing Taq and Pwo DNA Polymerase and another thermostable enzyme. The Expand 20 kbPLUS PCR System also includes an optimized reaction buffer, MgCl2 solution, and a human cont...
... N-term Antibody This antibody is generated from ... peptide selected within aa 50~150 of human ... PBS with 0.09% (W/V) sodium azide. This ... column and eluted out with both high ...
... 2 mM sodium phosphate buffer, pH 6.5. ... is a major lysosomal aspartyl protease in ... proenzyme. Overexpression of cathepsin D in human ... of relapse and metastasis. Cathepsin D degrades ...
Biology Products: