Navigation Links
Genetic risk for elevated arsenic toxicity discovered
Date:2/24/2012

ople around the world, and it opens up opportunities for genetic studies of other major public health problems in developing countries."

The researchers genotyped thousands of arsenic-exposed individuals from the group's main studies for single nucleotide polymorphisms (SNPs) throughout the genome, and looked for associations with arsenic metabolite levels and risk of skin lesions.

The genetic findings provide strong evidence that efficient metabolism of arsenic through methylation protects against the toxin. Compounds that boost methylation, such as folic acid, could reduce arsenic toxicity a strategy currently being tested by co-author Mary Gamble, PhD, associate professor of Environmental Health Sciences at Columbia University's Mailman School of Public Health.

"If we could somehow find a way to do that in Bangladesh, it would make individuals much better methylators of arsenic, and as this current study shows if you're a better methylator you're at a lower risk for disease," said co-author Joseph Graziano, PhD, professor of Environmental Health Sciences and Director of Superfund Research Program at the Mailman School of Public Health of Columbia University.

Beyond the clinical applications, the current study demonstrates that large-scale genomic studies are possible in a largely rural population of a developing country. The study offers a rare example of a GWAS result with clear, immediate potential for translational impact.


'/>"/>

Contact: Stephanie Berger
sb2247@columbia.edu
212-305-4372
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study finds college students willing to donate genetic material to biobanks for research
2. Wild west approach to claiming the oceans genetic resources must end: UBC media release
3. North Carolina-based genetic resources fuel big scientific progress
4. Genetic studies of special mice could lead to rapid human health advances
5. Cleveland Clinic joins 23andMe in the search for genetic clues to Parkinsons disease
6. Drug halts organ damage in inflammatory genetic disorder
7. New study sheds light on genetics of rice metabolism
8. New virtual tool may provide more accurate diagnosis of genetic mutations
9. Dyslexia-linked genetic variant decreases midline crossing of auditory pathways
10. Body clock receptor linked to diabetes in new genetic study
11. Genetics study reveals how bacteria behind serious childhood disease evolve to evade vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... certain traits from our parents that are pre-determined. But ... out by taking certain drugs or better yet, just ... of researchers at the Boston University School of Medicine ... , Epigenetics regulates gene expression in a reversible ... prevent permanent mutations or alterations within the gene themselves. ...
(Date:9/16/2014)... us sick can take up residence in and on ... other troublesome symptom, according to new research at Washington ... On average, healthy individuals carry about five types of ... BioMed Central Biology . The study is the ... in healthy people. , The research was conducted ...
(Date:9/16/2014)... has its own bacterial identity. That,s the conclusion of ... who studied the genetic fingerprints of bacteria on 57 ... "This study demonstrates for the first time that host ... strategies possess very different microbial communities on their leaves," ... researcher in the UO,s Institute of Ecology and Evolution ...
Breaking Biology News(10 mins):Epigenetic drugs: A hope to treat cancer resistance and reduce cancer relapse? 2Epigenetic drugs: A hope to treat cancer resistance and reduce cancer relapse? 3Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Microbiome research shows each tree species has a unique bacterial identity 2
... how compound word formation is influenced by subtle forms ... to the speakers of a language have a higher ... words are subject to selection pressures that play a ... language over time. The study, "Grammars leak: Modeling ...
... ARLINGTON, Va.Underscoring the importance of alternative energy for the ... Corps Base Hawaii Dec. 7 to learn about possible ... Research (ONR)-funded fuel cell vehicles (FCV) and high-efficiency trash ... the 70th anniversary of the Pearl Harbor attack, was ...
... bees and brains made up of neurons make decisions using ... 9 issue of Science . In previous work, ... a honeybee swarm perform "waggle dances" to prompt other scout ... In the new study, Seeley, a professor of ...
Cached Biology News:Survival of the fittest: Linguistic evolution in practice 2New energy sources fuel interest from Secretary of the Navy 2
(Date:9/16/2014)... 2014 --The emerging field of molecular electronics could ... level, enabling the construction of tiny circuits from ... molecules would take on the roles currently played ... team of researchers from five Japanese and Taiwanese ... in small-scale electronics: a molecule called picene. In ...
(Date:9/16/2014)... to cars and flashlights, batteries play an important ... constantly are seeking ways to improve battery life ... a water-based solution, researchers at the University of ... nuclear battery that could be used for many ... automobiles and also in complicated applications such as ...
(Date:9/16/2014)... created a deicing film for radar domes have now ... for glass. , The new work by Rice ... surfaces from windshields to skyscrapers free of ice and ... , The technology was introduced this month in ... Interfaces . , The material is made of ...
(Date:9/16/2014)... 16, 2014 BlueInGreen® , ... efficient method for delivering dissolved gases into liquids, ... as a manufacturer’s representative firm to its ... products for municipal water and wastewater applications in ... H2Flow was founded in 1992 and serves Quebec ...
Breaking Biology Technology:The future face of molecular electronics 2Nanoribbon film keeps glass ice-free 2BlueInGreen® Expands into Canada – Signs Representative Agreement with H2Flow Equipment Inc. 2
... /Xinhua-PRNewswire-FirstCall/ --,Kiwa Bio-Tech Products Group Corporation (OTC Bulletin ... products sold during the fourth,quarter of 2007 strengthened ... over the same period in the previous year., ... is a joint-venture of Kiwa,and Tianjin Challenge Feed ...
... Tengion Inc., a clinical,stage regenerative medicine company ... today that Steven Nichtberger, M.D.,President and Chief Executive ... Pharmaceutical, Biotechnology and Medical Device Conference on,Tuesday, February ... will be held at,the Grand Hyatt Hotel in ...
... Inc. (OTC Bulletin Board: CARN) said it retained,Milkie/Ferguson ... it in,exploring a range of financial alternatives., ... continuation of our efforts to,thoroughly consider our business ... PhD, chief executive officer of Carrington.,"We have valuable ...
Cached Biology Technology:Kiwa Bio-Tech Animal Feed Volume Increased 25% in Fourth Quarter of 2007 2Carrington Retains Milkie/Ferguson to Explore Financial Alternatives 2
IgD Chain C (AMS 9.1)...
Bethyl Laboratories packages antibodies, conjugates and calibrators to provide quantitative ELISA kits. Each kit contains the following components, sufficient for 1000 single well assays....
quantitation of phosphatase activity, evaluation of hits and leads from HTS...
... 9001:2000 Certified USDA Research Registered OLAW Assured ... Training AALAS Certified Technicians Documentation ... Documentation Upon Request Focus CRP ... all your custom immunology service needs. ...
Biology Products: