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Genetic risk factors may tailor prostate cancer screening approaches
Date:11/17/2008

ve no family or personal history of the disease. The men in the control group are at low risk for developing prostate cancer. Analysis revealed that while there was an effect found for increased risk for prostate cancer in Caucasian men at high-risk for several of these markers, none of the results were statistically significant. This could be related to the low sample size used in the study. When comparing these five genetic markers in high-risk Caucasian men with men already diagnosed with prostate cancer, the distribution of the markers was similar. This might indicate that these markers are clinically useful in Caucasian men at risk for prostate cancer, although further study is needed.

"When we compared African-American men in PRAP to the high-risk Caucasian men in PRAP, we did find a difference," she said. "African-American men tended to carry more of these genetic risk markers compared to the Caucasian men. Since African-American men carry more of these particular genetic markers, they may be more informative for prostate cancer risk assessment in African-American men."

The researchers then studied how these markers influence time to prostate cancer diagnosis. "We found a trend that African-American men who carried more of these risk markers tended to develop prostate cancer earlier," Giri said. This finding did not reach statistical significance.

Giri said the take-home message from this study is that genetic markers associated with prostate cancer risk need to be characterized in prospective screening populations in order to determine how to incorporate them into risk assessment for prostate cancer, particularly for men at high-risk for the disease. "These markers may have significant use in personalizing the early detection of prostate cancer in men at high-risk in order to provide tailored recommendations for screening and diagnosis of this disease," said Giri.


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Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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