Navigation Links
Genetic risk factors may tailor prostate cancer screening approaches
Date:11/17/2008

Men with a family history of prostate cancer and African-American men are particularly susceptible to the disease, with a twofold to sevenfold increased risk. Assessing risk in these populations has been difficult.

"There have been years of effort to try to identify genes and genetic mutations associated with prostate cancer as there are for breast cancer," said Veda N. Giri, M.D., director of the Prostate Cancer Risk Assessment Program (PRAP) at Fox Chase Cancer Center, Philadelphia. "Prostate cancer is a more genetically complex disease."

Giri and colleagues studied patients who are part of the center's Prostate Cancer Risk Assessment Program, an early detection program for men with a high prostate cancer risk. More than 700 participants are enrolled; 60 percent are African-American.

The investigators evaluated the clinical characteristics of men at high risk for prostate cancer; those who carry five genetic single nucleotide polymorphisms (SNPs) that have been associated with prostate cancer in recent studies. These genetic changes have mostly been reported in predominantly Caucasian populations and are being studied in African-American men as well.

"We are interested in looking at how these genetic risk markers can be used for assessing the risk for prostate cancer in high-risk men," said Giri. "These are men who have not yet developed prostate cancer, such as African-American men and men with family members with the disease. Can these markers be used as an indicator of upcoming prostate cancer?"

The men enrolled in PRAP are aged 35 to 69 years and meet one of the following criteria: one first-degree relative with prostate cancer or two second-degree relatives with prostate cancer on the same side of the family. The group also includes African-American men with BRCA 1/2 mutations.

Giri and colleagues compared the Caucasian high-risk men in PRAP with a control group, an all-Caucasian set of men who ha
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Sicilian word enters British genetic language
2. Case Western Reserve University uncovers genetic basis for some birth defects
3. Genetic predictors of esophageal cancer identified
4. Seasonal affective disorder may be linked to genetic mutation, study suggests
5. Study sheds light on genetic differences that cause a childhood eye disease
6. Living fossil tree contains genetic imprints of rain forests under climate change
7. Genetic evidence for avian influenza movement from Asia to North America via wild birds
8. Genetic based human diseases are an ancient evolutionary legacy
9. Modern genetics vs. ancient frog-killing fungus
10. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
11. Can genetic information be controlled by light?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... Access to Research Careers) Program has announced the ... America,s 27th Annual Mouse Molecular Genetics Conference from ... Grove, California. These awards are meant to ... scientists from underrepresented groups into the mainstream of ... participation of young scientists at the Genetics Society ...
(Date:8/28/2014)... MARC (Maximizing Access to Research Careers) Program has ... College of Sports Medicine,s Conference on Integrative Physiology ... Florida. These awards are meant to promote ... from underrepresented groups into the mainstream of the ... of young scientists at the American College of ...
(Date:8/28/2014)... release is available in German . ... are now built with the help of sophisticated assembly lines. ... are an important part of these assembly lines. In the ... in various work stages arranged in a precise spatial and ... of the line. , The creation of such an assembly ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3
... More than six percent of expectant mothers in Quebec consume ... fetuses, according to a Universit de Montral investigation published in ... these women will voluntarily terminate their pregnancy fearing congenital malformations, ... percent higher than in the rest of the population. ...
... , REDWOOD CITY, Calif., Nov. 17 ... and authentication solutions, today announced that its customer, ... in security and privacy protection for its Picis ... incorporates DigitalPersona,s U.are.U® Fingerprint Readers and One Touch® ...
... Centre in Norwich, UK, have shown how plants can protect ... growing tips of plant roots and shoots have an in-built ... the cell to ,commit suicide, rather than pass on its ... roots and shoots, small populations of stem cells, through which ...
Cached Biology News:Some prescription meds can harm fetus 2Picis ED PulseCheck Increases Security and Privacy Protection in Nearly 150 Hospitals Through the Use of DigitalPersona Biometrics 2Picis ED PulseCheck Increases Security and Privacy Protection in Nearly 150 Hospitals Through the Use of DigitalPersona Biometrics 3Protecting the future: How plant stem cells guard against genetic damage 2
(Date:8/28/2014)... , Aug. 28, 2014  Armetheon, Inc. ... developing novel mid- to late-stage cardiovascular drug candidates, ... in its first round of financing. The Series ... and Hercules Bioventures with participation from investors that ... pharmaceutical executive, Dr. Larry Hsu , the ...
(Date:8/28/2014)... Earlier this month, a report ... with the U.S. Air Force on the performance of ... that this type of fuel made from mustard seeds, ... important to America’s Eco friendly future. In fact, every ... to become independent of foreign oil over the next ...
(Date:8/27/2014)... Varian Medical Systems today broke ground ... Lake City manufacturing facility and allow for the consolidation ... create 1,000 new full time jobs in the state ... home to hardworking people with immense engineering and technical ... success in the manufacturing of our state-of-the-art X-ray technology,” ...
(Date:8/27/2014)... YORK , Aug. 27, 2014 /PRNewswire/ ... research report is available in its catalogue: ... 2014-2018 http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials are materials that are readily decomposed ... differs from conventional non-degradable packaging in terms ...
Breaking Biology Technology:Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... with researchers from Grenoble and Tokyo, have succeeded in taking ... They were able to define two little quantum dots (QDs), ... single electron from one of them using a sound wave, ... single electron "surfs" thus from one quantum dot to the ...
... Parent Project Muscular Dystrophy (PPMD) , the ... a cure for Duchenne muscular dystrophy (Duchenne) , announced ... of Physiology at the University of Pennsylvania and Pennsylvania Muscle ... (Logo: http://photos.prnewswire.com/prnh/20100119/DC39975LOGO ) Dr. Khurana is ...
... Inc., a privately-held global diagnostics company for human and ... president and CEO, will be presenting at AdvaMed 2011: ... 2011 at 11:00 a.m. in room 204A of the ... The presentation will include an overview of ...
Cached Biology Technology:Like fish on waves: electrons go surfing 2Like fish on waves: electrons go surfing 3Parent Project Muscular Dystrophy Awards End Duchenne Grant to University of Pennsylvania's Dr. Tejvir S. Khurana 2Parent Project Muscular Dystrophy Awards End Duchenne Grant to University of Pennsylvania's Dr. Tejvir S. Khurana 3SuperNova Diagnostics® to Present at AdvaMed 2011: The Medtech Conference in Washington, D.C. 2
... effect inhibition assays, also known as CPE and ... supernatents; serum from PK studies and delivery formulations. ... as the quantity of interferon required per milliliter ... by 50%. All standards used in ...
Request Info...
Request Info...
... Nebulizers are available in two product models - ... two models is that the 6000AT+ includes a ... drier aerosol for improved detection limits and reduced ... a range of elements by 10-40 times. Note ...
Biology Products: