Navigation Links
Genetic predictors of esophageal cancer identified
Date:11/4/2008

PHILADELPHIA Researchers have identified 11 genotypes that may increase esophageal cancer risk, according to research published in the November issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.

"We observed a significantly increased risk of esophageal cancer with increasing numbers of risk genotypes," said Yuanqing Ye, Ph.D., an instructor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center.

Major risk factors for esophageal cancer include obesity, smoking and gastroesophageal reflux disease. Compared to the high prevalence of these risk factors in the general population, the incidence rate of esophageal cancer is low, indicating that a small percentage of people are genetically predisposed to develop esophageal cancer.

Researchers at the University of Texas M. D. Anderson Cancer Center identified 11 single-nucleotide polymorphisms (SNPs) in microRNA-related genes that showed at least a borderline significant association with esophageal cancer. A person can have one or more of these SNPs in their genetic makeup, putting him or her into low-risk, medium-risk and high-risk groups. The study showed that each unfavorable genotype was associated with an increased cancer risk. Individuals with more than four unfavorable genotypes were more than three times as likely to develop esophageal cancer.

"Our ultimate goal is to construct a quantitative cancer risk prediction model based on an individual's epidemiological profile, environment exposure and genetic makeup," said Xifeng Wu, M.D., Ph.D., a professor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center and lead author of the study. "This risk prediction model can evaluate each person's relative risk and absolute risk of developing esophageal cancer within a certain time period."

Esophageal cancer is the fastest growing cancer in the United St
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

2

GOOD

Page: 1 2

Related biology news :

1. Seasonal affective disorder may be linked to genetic mutation, study suggests
2. Study sheds light on genetic differences that cause a childhood eye disease
3. Living fossil tree contains genetic imprints of rain forests under climate change
4. Genetic evidence for avian influenza movement from Asia to North America via wild birds
5. Genetic based human diseases are an ancient evolutionary legacy
6. Modern genetics vs. ancient frog-killing fungus
7. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
8. Can genetic information be controlled by light?
9. Clue to genetic cause of fatal birth defect
10. American College of Medical Genetics receives $13.5M NIH contract
11. Genetic finding implicates innate immune system in major cause of blindness

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2009)... , This release is available in German . ,... Collaborative Research Centres as of 1 January 20...t Grants Committee in Bonn. The new centres will i...132 million. In addition, 20 percent overhead fund...ach project. The centres, research topics range fr...
(Date:11/30/2009)... , Two so-called invasion proteins are crucial fo... surface of human cells, which stimulates the host...eptor molecules exert a different function, for ex...ing. The group,s results have now been published i...Biology ". , Spoiled meat is one of the sources ...
(Date:11/30/2009)... , A new research report published in the Decembe...e day give men similar type of control over their ...t,s because scientists have found how and where an...rmal sperm production and male fertility. This ope...pill" for men. The discovery also offers hope to t...
Breaking Biology News(10 mins):DFG approves funding for 17 new collaborative research centers 2DFG approves funding for 17 new collaborative research centers 3DFG approves funding for 17 new collaborative research centers 4DFG approves funding for 17 new collaborative research centers 5DFG approves funding for 17 new collaborative research centers 6DFG approves funding for 17 new collaborative research centers 7DFG approves funding for 17 new collaborative research centers 8DFG approves funding for 17 new collaborative research centers 9It takes 2 to infect 2Internet May Be Newest Venue for Teen Tobacco Exposure 52122 1Internet May Be Newest Venue for Teen Tobacco Exposure 52122 2Internet May Be Newest Venue for Teen Tobacco Exposure 52122 3BeneChill Raises 2413 5 Million Series C 52120 1BeneChill Raises 2413 5 Million Series C 52120 2RealMed Corporation and TSI Healthcare Announce Strategic Partnership 52118 1RealMed Corporation and TSI Healthcare Announce Strategic Partnership 52118 2
... Mass Media Fellows, Wendy Hansen and Maddalena J...eering and technology as part of a 10-week interns...nd Sacramento Bee, respectively. , Wendy Hansen ...of,California-Berkeley; and Maddalena Jackson is a...Calif., with a B.S. in engineering. , In her appl...
...s is a team of pioneers. While most ocean robots r...tellite intermediaries to share information, these...ch other. , Over the past five years Kristi Morg...sor of aeronautics and astronautics, has built thr...rwater. Recently at the International Federation o...
...y are the first to observe the dynamic, ratchet-li...act of building proteins from genetic blueprints. ...r Cell, reveals a key mechanism in the interplay o...s needed to sustain life. , Cells use a variety o...r RNA, a ribbon-like molecule that codes for the s...
Other Biology News:School of Robofish provides basis for underwater robot teams 2School of Robofish provides basis for underwater robot teams 3Researchers observe spontaneous 'ratcheting' of single ribosome molecules 2Researchers observe spontaneous 'ratcheting' of single ribosome molecules 3
(Date:11/25/2009)...e/ -- Biotech firm Replikins Ltd., which has analy...demic through the prediction, outbreak, and progre...latest biochemical analysis of the virus. The new ...Flu") virus has dropped from its peak of 3.7 (s.d....pring of 2009 to resting non-epidemic levels this ...
(Date:11/25/2009)...ATON, Fla., Nov. 25 For many busin...dyLogicMD. The nation,s largest and fastest growi...sively in medically supervised bioidentical hormo... network since November 2008 - from 21 to 36 ph...an-owned centers, including one in Puerto Rico, by...
(Date:11/25/2009)...ewswire-Asia/ -- Sinovac Biotech Ltd. ( SVA),a le...d today that it executed,a joint venture (JV) agre...logy Co., Ltd. (Sinovac Dalian). The JV will resea...vaccines. Sinovac will contribute its expertise,an...ld-class vaccines; the,other party will bring its ...
(Date:11/25/2009)...FirstCall/ -- Ardea Biosciences, Inc. (Nasdaq: RD..., president and chief executive officer, will pres...onference. , ,Presentation details are as follows...e,Date: Tuesday, December 1, 2009,Time: ...ace Hotel, New York, NY,Webcast: <a href=,http:...
Breaking Biology Technology:Biological H1N1 Vaccines: Too Little, Too Late 2Biological H1N1 Vaccines: Too Little, Too Late 3Biological H1N1 Vaccines: Too Little, Too Late 4Biological H1N1 Vaccines: Too Little, Too Late 5Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 2Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 3Nation's Largest Network of Doctors Specializing in Bioidentical Hormones Grows at an Exponential Rate 4Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 2Sinovac Establishes Joint Venture to Expand Human-Use Vaccine Development and Manufacturing Capabilities 3Ardea Biosciences to Present at the Piper Jaffray 21st Annual Health Care Conference 2
...ana miRNA Probe Set and mir Vana , miRNA L...ecting miRNAs on Microarrays , ... species that represent approximate... RNA in a sample (10 g total RNA contains ~1 ng mi... and low abundance, miRNAs can be extremely , ...
...viral-mediated Delivery of siRNA , , ..., enables researchers to study ... the expression of specific genes in cell cult...vectors make use of H1 or U6 Polymerase III , ... even in , difficult-to-transfe...
... mirVana PARIS Kit--Optimized for Recovery of siRN... Small RNA, mRNA, and Protein , Amb...technological advances from both the <A , ...tNum.php?1560">mir <A , href="..., miRNA Isolation Kit , optimized for small...
Other Biology Technology:Highly Sensitive microRNA Array Performance 2Highly Sensitive microRNA Array Performance 3Highly Sensitive microRNA Array Performance 4Highly Sensitive microRNA Array Performance 5Highly Sensitive microRNA Array Performance 6Highly Sensitive microRNA Array Performance 7Highly Sensitive microRNA Array Performance 8Enhanced siRNA Delivery and Long-term Gene Silencing 2Enhanced siRNA Delivery and Long-term Gene Silencing 3Enhanced siRNA Delivery and Long-term Gene Silencing 4Enhanced siRNA Delivery and Long-term Gene Silencing 5Enhanced siRNA Delivery and Long-term Gene Silencing 6Enhanced siRNA Delivery and Long-term Gene Silencing 7Enhanced siRNA Delivery and Long-term Gene Silencing 8Enhanced siRNA Delivery and Long-term Gene Silencing 9Enhanced siRNA Delivery and Long-term Gene Silencing 10Isolate Total RNA and Protein From the Same Sample 2Isolate Total RNA and Protein From the Same Sample 3Isolate Total RNA and Protein From the Same Sample 4Isolate Total RNA and Protein From the Same Sample 5
... be upgraded to the GenePix Autoloader 4200AL. The...alyzes, and saves results for up to 36 slides, the.... Line-by-line autofocus ensures superior field un...s you complete flexibility to configure scanning a...
Affymetrix Standard Data Analysis Report from Asuragen, Inc.
Illumina Standard Data Analysis Report from Asuragen, Inc.
CORNING 1700CM2 ROLLER BOTTLE, EASY GRIP CAP, GRADUATED, STERILE from Sigma-Aldrich
Biology Products: