Navigation Links
Genetic predictors of esophageal cancer identified
Date:11/4/2008

PHILADELPHIA Researchers have identified 11 genotypes that may increase esophageal cancer risk, according to research published in the November issue of Cancer Prevention Research, a journal of the American Association for Cancer Research.

"We observed a significantly increased risk of esophageal cancer with increasing numbers of risk genotypes," said Yuanqing Ye, Ph.D., an instructor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center.

Major risk factors for esophageal cancer include obesity, smoking and gastroesophageal reflux disease. Compared to the high prevalence of these risk factors in the general population, the incidence rate of esophageal cancer is low, indicating that a small percentage of people are genetically predisposed to develop esophageal cancer.

Researchers at the University of Texas M. D. Anderson Cancer Center identified 11 single-nucleotide polymorphisms (SNPs) in microRNA-related genes that showed at least a borderline significant association with esophageal cancer. A person can have one or more of these SNPs in their genetic makeup, putting him or her into low-risk, medium-risk and high-risk groups. The study showed that each unfavorable genotype was associated with an increased cancer risk. Individuals with more than four unfavorable genotypes were more than three times as likely to develop esophageal cancer.

"Our ultimate goal is to construct a quantitative cancer risk prediction model based on an individual's epidemiological profile, environment exposure and genetic makeup," said Xifeng Wu, M.D., Ph.D., a professor in the Department of Epidemiology at the University of Texas M. D. Anderson Cancer Center and lead author of the study. "This risk prediction model can evaluate each person's relative risk and absolute risk of developing esophageal cancer within a certain time period."

Esophageal cancer is the fastest growing cancer in the United States with significantly increasing rates of occurrence. The majority of esophageal cancer patients are diagnosed at an advanced stage with poor prognosis. Understanding what places a person at high risk for esophageal cancer may have clinical applications to guide cancer screening, intensive monitoring, and cancer prevention.

"Considering the dramatic increase in incidence, difficulty of early diagnosis, the poor survival rate for esophageal cancer, and the limited knowledge of the natural history of this tumor, we need a greater understanding of the etiology of esophageal cancer for improvement of diagnosis and hopefully a better prognosis," said Wu.


'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Seasonal affective disorder may be linked to genetic mutation, study suggests
2. Study sheds light on genetic differences that cause a childhood eye disease
3. Living fossil tree contains genetic imprints of rain forests under climate change
4. Genetic evidence for avian influenza movement from Asia to North America via wild birds
5. Genetic based human diseases are an ancient evolutionary legacy
6. Modern genetics vs. ancient frog-killing fungus
7. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
8. Can genetic information be controlled by light?
9. Clue to genetic cause of fatal birth defect
10. American College of Medical Genetics receives $13.5M NIH contract
11. Genetic finding implicates innate immune system in major cause of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... 11, 2017 No two people are ... the New York University Tandon School of Engineering ... found that partial similarities between prints are common ... mobile phones and other electronic devices can be ... vulnerability lies in the fact that fingerprint-based authentication ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Singh Biotechnology today ... designation to SBT-100, its novel anti-STAT3 (Signal Transducer and Activator of Transcription 3) ... able to cross the cell membrane and bind intracellular STAT3 and inhibit its ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/10/2017)... ... October 10, 2017 , ... The Pittcon Program ... honoring scientists who have made outstanding contributions to analytical chemistry and ... 2018, the world’s leading conference and exposition for laboratory science, which will be ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
Breaking Biology Technology: