Navigation Links
Genetic patterns rise from huge yeast samples
Date:4/14/2010

ind these groupings, leading to the "missing" problem.

Kruglyak was part of an expert panel the National Human Genome Research Institute convened last year on the missing heritability problem. When the Human Genome Project was completed in 2003, it provided an entire sequence of human DNA. The panel discussions centered upon the idea that, despite major technology advances made possible by the project and studies of tens of thousands of individuals, the great majority of the genetic factors responsible for differences between individuals have not yet been found.

"In many cases, the effects of genes are so small that detecting them is extremely difficult," said Ian Ehrenreich, a postdoctoral research fellow who is the first author on the Nature paper. "Under conventional methods, we just don't have the power to identify many of these genes. We knew we had to find a different way."

The method described in the paper is "a creative adaptation of existing family-based, genome-wide methodology," said Yin Yao, who is chief of the molecular and genetic epidemiology program in the division of neuroscience and basic behavioral science at the National Institute of Mental Health. She and Thomas Lehner, chief of the genomic research branch at the institute, said Kruglyak's work is highly valued and described him as a pioneer in the field of statistical genomics.

Scientists in Kruglyak's lab conduct experiments on organisms like yeast, as well as perform computational analyses, aimed at understanding how changes in DNA are shaped by molecular and evolutionary forces. They also study how these changes lead to the observable differences among individuals within a species. For this research project, the team looked to develop a process that would identify genetic associations with observable traits.

"We know in the human genome there are 20,000 genes, but I can't ask someone to point out to me which genes account for most
'/>"/>

Contact: Kitta MacPherson
kittamac@princeton.edu
609-258-5729
Princeton University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Primary cilia formation provides insight into genetic diseases
2. Genetically engineered crops benefit many farmers, but the technology needs proper management to remain effective
3. Variations on the genetic theme
4. Genetic key discovered to dramatically increase yields and improve taste of hybrid tomato plants
5. New genetic risk factors for aneurysms identified by Yale-led team
6. UMMS researchers uncover novel genetic pathway responsible for triggering vascular growth
7. Ayman El-Hattab, MD is awarded the 2010 Genzyme/ACMG Foundation Genetics Fellowship
8. Leader in genetics, Dr. David L. Rimoin, receives ACMG Foundation Lifetime Achievement Award
9. Dian Donnai receives lifetime award in genetics from March of Dimes
10. UC-developed technology to assist research and genetic drug delivery
11. Anesthesia increases risk of developing Alzheimers disease in patients with genetic predisposition
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic patterns rise from huge yeast samples
(Date:9/30/2014)... Journal of Medicine reports positive results of a ... the subset of lung cancer marked by rearrangement of ... patients with advanced non-small cell lung cancer testing positive ... percent, with 3 complete responses and 33 partial responses. ... the disease to resume its growth after being slowed ...
(Date:9/30/2014)... Pollution in urban and farm runoff in Hawaii is ... finds. , The study, published Tuesday in the ... in the runoff ends up in algae that the ... animals, eyes, flippers and internal organs. , Scientists at ... Oceanic and Atmospheric Administration (NOAA) conducted the study to ...
(Date:9/30/2014)... what goes wrong with your muscles because of age, disease ... actually is. That,s where a new research report published in ... comes in. In the report, a team of ... can help scientists "see" which genes are active in an ... gene activity and that men have approximately 400 more active ...
Breaking Biology News(10 mins):NEJM: Crizotinib effective in Phase 1 trial against ROS1 lung cancer 2Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Scientists identify which genes are active in muscles of men and women 2
... ( Glis glis ) are busy caring for their young ... their fat stores to cope with the upcoming winter. Unfortunately, ... and dormice have long been viewed as a special delicacy. ... up for eating, which explains the "edible" part of their ...
... Claremont, CA A chance find by a high ... complete fossil skeleton yet known from the iconic tube-crested ... the Raymond M. Alf Museum of Paleontology at The ... strange headgear before it celebrated its first birthday. Three-dimensional ...
... in the soil and leaks out as nitrate for decades ... France and at the University of Calgary say in a ... had been applied to crops in 1982, about 15 per ... matter, the scientists found. After three decades, approximately 10 ...
Cached Biology News:Fat and fit 2High school student discovers skeleton of baby dinosaur 2High school student discovers skeleton of baby dinosaur 3Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find 2Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find 3
(Date:10/1/2014)... 30, 2014 New applications of structures ... have evolved in nature over millennia are featured in ... for applications in biophotonics in the October issue ... journal is published by SPIE, the international society for ... of the peer-reviewed articles are accessible via open access. ...
(Date:10/1/2014)... The U.S. Department of Labor has awarded ... as part of the Trade Adjustment Assistance Community College ... by the Department of Labor and Department of Education. ... E. Perez and Secretary of Education Arne Duncan announced ... to nearly 270 colleges across the country. , ...
(Date:9/30/2014)... D.C., September 30, 2014 Applying a well-known ... researchers at Harvard University has demonstrated the ability ... -- work that holds promise for making future, ... detailing the sides of next-gen rocket ships and ... light passes through oil in water, it becomes ...
(Date:9/30/2014)... Sept. 30, 2014 Report Details ... highest potential revenues Do you want to find ... you revenue predictions for those biological drugs from ... you find financial data, R&D trends, opportunities and ... sales forecasts to 2024 at overall world market, ...
Breaking Biology Technology:Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 2Biomimetic and bioinspired materials enable new healthcare options, reports Journal of Biomedical Optics 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 2U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 3U.S. Dept. of Labor Awards SIUE Nearly $10-Million Grant 4Taking thin films to the extreme 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5
... Quantified - ... HOPKINTON, Mass., April 24 Caliper Life,Sciences, Inc. ... and services for,drug discovery and life sciences research, today ... coast business operations to,reduce overall facility costs and improve ...
... Therapeutics,Inc. (Nasdaq: FOLD ), today announced that John ... corporate update at the Morgan,Stanley Global Healthcare Unplugged Conference ... the Ritz-Carlton in Key Biscayne, Florida., The presentation ... visiting,Amicus, website at http://www.amicustherapeutics.com . A replay of ...
... Inc.,(Nasdaq: CEPH ) today announced its receipt ... an Abbreviated New Drug Application (ANDA),submitted to the ... Inc., requesting approval to market and sell a ... its Notice,Letter, Watson alleges that the U.S. Patent ...
Cached Biology Technology:Caliper Life Sciences Reports West Coast Consolidation of Operations 2Caliper Life Sciences Reports West Coast Consolidation of Operations 3Caliper Life Sciences Reports West Coast Consolidation of Operations 4Cephalon Notified of Generic Fentanyl Buccal Tablet Filing 2Cephalon Notified of Generic Fentanyl Buccal Tablet Filing 3
... On-Demand Cytometry The Guava ... blue laser based multiparameter cytometer with built-in ... you can screen plates of cells and ... of manipulating multiple tubes or having the ...
A flexible 24-48 hour DNA sequencing service. Samples may be shipped in standard 1.5mL tubes. Oligo synthesis and DNA preparation available. Read lengths up to 850 Phred 20 bases. Universal primers p...
... Agencourt offers single pass sequencing of ... is fueled by our high performance ... million Phred20 bases per day. The ... pass sequencing customers are rapid turnaround, ...
... Facility , Galaxy LIMS, Sophisticated Bioinformatics , ... scientists ,We offer individual sample sequencing of ... for single or double strand publication quality. ... DNA of interest is 1.3 to 7 ...
Biology Products: