Navigation Links
Genetic mystery of Behcet's disease unfolds along the ancient Silk Road
Date:1/6/2013

common illnesses, and thereby suggest new therapies for Behcet's disease. In addition, two of the newly discovered genes provide an intriguing link between genes and the microbes in our environment."

Researchers conducted a genome-wide association study (GWAS) that enrolled 1,209 Turkish people affected by Behcet's disease and 1,278 unaffected Turkish peopleall residents of the country. They looked at many points on the human genome called single-nucleotide polymorphisms (SNPs), with each SNP representing a difference in a single DNA building block, called a nucleotide. Researchers then compared SNP differences between people with and without disease.

From nearly 800,000 SNPs, researchers detected and mapped a small number that are found in those who have Behcet's disease at a significantly higher rate than in those without the disease, suggesting that the variant or another one nearby contributes to the disease.

"Each of the genetic factors may contribute a little to the overall risk of disease," said Elaine F. Remmers, Ph.D., staff scientist in NHGRI's Inflammatory Disease Section and study co-author. "We are also identifying them in pathways that are important in inflammatory disease development."

She noted that not all of the 800,000 gene variants analyzed were directly genotyped. Genotyping involves examining a person's DNA at a site where a variation is commonly known to occur. Instead, the team used the strategy of imputing, or surmising, that there were genotypes worth investigating near known variants.

"That worked very well for us," Dr. Remmers said. "We found that our predicted genotypes were pretty good and that the associations we found were quite similar in both the predicted and the experimentally confirmed genotypes."

Each of the four newly identified gene regions is already known to play a role in immune regulation. The genetic associations have helped classify Behcet's disease with more commo
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Genetics Society of America announces Spring 2013 DeLill Nasser Travel Award recipients
2. GW professor discovers new information in the understanding of autism and genetics
3. Genetic sequencing breakthrough to aid treatment for congenital hyperinsulinism
4. 3 new genetic links to colorectal cancer
5. Gout study offers genetic insight into disease of kings
6. New findings in the search for genetic clues to insulin production
7. Researchers discover genetic basis for eczema, new avenue to therapies
8. Transplanted genetically-modified adipose cells offer potential therapy for liver diseases
9. Discovery may pave way to genetically enhanced biofuel crops
10. Game changing diagnostic & prognostic prostate cancer genetic tests revealed by Jefferson
11. USDA explores using novel genetic labs for faster detection of E. coli
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... Gutenberg University Mainz (JGU) as a full member, ... maintain a significant nationwide standing in the field ... Johannes Gutenberg University Mainz as a full member ... national and international competition for the best minds ... be proud that Mainz University has been recognized ...
(Date:10/15/2014)... bacterial pneumonia in female mice to an enzyme activated ... naturally more resistant to respiratory infections than males. Now, ... resistance to bacterial pneumonia in female mice is linked ... also show that this enzyme is ultimately activated by ... The team, lead by Professor Lester Kobzik at the ...
(Date:10/15/2014)... the 44th Rosenstiel Award for Distinguished Work in Biomedical ... the mechanisms of genomic instability and its implications for ... second alumnus to win the Rosenstiel Award; the first, ... Alt is the Charles A. Janeway Professor of Pediatrics ... an investigator at the Howard Hughes Medical Institute at ...
Breaking Biology News(10 mins):Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 2Johannes Gutenberg University Mainz joins Germany's Gauss-Allianz as a full member 3Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2
... of the Canadian Journal of Forest Research presents ... one of the first landscape-scale experiments on how ... The Blacks Mountain Interdisciplinary Research team includes U.S. ... U.C. Riverside, University of Georgia and Wildlife Conservation ...
... ago, bird beaks are exquisitely adapted to the birds, feeding ... explained exactly how some shorebirds use their long, thin beaks ... The phalarope, commonly found in western North America, takes advantage ... propel bits of food from the tip of its long ...
... Mass.--Having found that whether bacteria stick to surfaces depends ... have created ultrathin films made of polymers that could ... control microbe accumulation. The inexpensive, easy-to-produce films could ... care industry by helping to reduce the spread of ...
Cached Biology News:Pioneering landscape-scale research releases first findings 2MIT solves gravity-defying bird beak mystery 2MIT solves gravity-defying bird beak mystery 3MIT crafts bacteria-resistant films 2MIT crafts bacteria-resistant films 3
(Date:10/22/2014)...   Synthetic Biologics, Inc. (NYSE MKT: SYN), ... infections and diseases, announced today that the U.S. Patent ... for a composition of matter patent application that covers ... SYN-004. This is Synthetic Biologics, first allowed patent application ... to the Company,s extensive C. difficile patent ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems ... and Labeling Systems, Table-top Counters) by End-user (Inpatient ... & Trends to 2019” analyzes and studies the ... America, Europe, Asia-Pacific, and the Rest of the ... 30 figures spread through 300 pages and in-depth ...
(Date:10/20/2014)... , October 20, 2014 , ... (GI) disorders and the delivery of care has revealed ... and worrying inequalities in the provision of healthcare services ... was commissioned by United European Gastroenterology (UEG), have been ... and public awareness of the burden of GI disorders ...
(Date:10/20/2014)... OR (PRWEB) October 20, 2014 Local ... participate in an investigational study of donor stem cells ... in stem cell therapy and has performed clinical stem ... this study is to determine if a single injection ... affected joints can help reduce pain and inflammation in ...
Breaking Biology Technology:Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 2Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 3Synthetic Biologics Announces Allowance of Key U.S. Composition of Matter Patent for C. difficile Program 4Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5Cascade Veterinary Referral Center Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... CHARLOTTESVILLE, Va., Oct. 5, 2011 ZyGEM Corp. Ltd., ... analysis of DNA and other nucleic acids, today announced ... forensic GEM® Tissue kit can rapidly extract DNA from ... be used to produce accurate, reliable and reproducible DNA ...
... Hospital and Medical Center and the University of Arizona College ... the Valley Fever Center based at the hospital.  The center ... than 30 years of experience in treating and researching Valley ... Tucson in 1996. The center plans to see ...
... Oct. 4, 2011 MSC Care Management, the ... to post-discharge and post-injury workers, compensation claimants nationwide, ... Services, a national company also focused on the ... comprehensive surgical implant cost management solution, known as ...
Cached Biology Technology:Application Note Shows ZyGEM's forensicGEM® Tissue Facilitates Forensic Casework by Rapidly and Reproducibly Extracting DNA From Human Hair 2Application Note Shows ZyGEM's forensicGEM® Tissue Facilitates Forensic Casework by Rapidly and Reproducibly Extracting DNA From Human Hair 3St. Joseph's Hospital, University of Arizona Create Valley Fever Center in Phoenix 2MSC to Offer Surgical Implant Cost Management Solution through Acquisition of Integrated Healthcare Services 2
... [EP282Y] to Asparagine synthetase ( ... applications). Antigen: ... residues in the C-terminus of ... Entrez GeneID: 440 ...
Shh Antibody Shipping Temperature: HOT Storage Temperature: -20C...
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
Biology Products: