Navigation Links
Genetic markers may predict when people with heart disease are likely to have a heart attack
Date:3/30/2014

Researchers at the Intermountain Medical Center Heart Institute in Salt Lake City have identified a biological process that may help physicians predict when someone with heart disease is likely to have a heart attack in the near future.

A new study by the team has identified plasma levels of two markers microRNA 122 and 126 that appear to decline a few days before a person suffers a heart attack. Results of the study could help the 715,000 Americans who suffer from heart attacks each year.

"It's always been a mystery trying to identify people with heart disease who are at imminent risk of having a heart attack," says Oxana Galenko, DBMSC, with the Intermountain Medical Center Heart Institute Cardiovascular Research Laboratory, who is the lead researcher in the study. "Currently, there's no blood test that allows us to say, 'yes, this person will likely have a heart attack in the near future'. But identifying what happens to these markers has given us a place to start."

Researchers will present results of the study at the 2014 American College of Cardiology Scientific Sessions in Washington, DC, on Sunday, March 30 at 3:45 p.m. EDT.

During a heart attack, one of the coronary arteries that feed blood into the heart becomes completely blocked, preventing necessary oxygen and nourishment from reaching the heart muscle. When this happens, the heart muscle dies and never recovers resulting in heart failure or death.

The discovery of the diminishing microRNA markers began with the understanding of a basic process in biology known as the central dogma. DNA contains the genetic information an organism uses to grow and develop. Messenger ribonucleic acid (mRNA) communicates this information to the rest of the body and translates the genetic information into protein. This is known as gene expression.

In 1993 scientists discovered small forms of RNA didn't follow standard translation patterns. These forms, known as microRNA, weren't making proteins, but rather were interfering with mRNA to prevent translation.

At the same time, physicians at the Intermountain Medical Center Heart Institute created the Intermountain Heart Study Registry, which includes blood samples from a massive number of heart patients for research. Today the registry contains more than 30,000 DNA samples.

Galenko and her team looked at samples in the registry from 30 patients who had suffered a heart attack within 44 days of having their blood collected.

Researchers examined factors such as age, gender, race, elevated amounts of or cholesterol in the bloodstream, high blood pressure, and diabetes. They noticed that within two weeks of experiencing a heart attack, patient's microRNA 122 and 126 dramatically dropped.

The result: Galenko believes that something about these microRNAs being present and interrupting the translation process prevents people with heart disease from having a heart attack.

"MicroRNAs turn things off. Whatever they usually turn off in people with heart disease before a heart attack isn't being turned off when microRNA levels are reduced, which may be causing something else to be activated," she says. "MicroRNAs act like a watch dog, and when their levels are reduced, heart disease takes a turn for the worse and heart attacks are likely to occur."

Further research is needed to find out more about what takes place when the microRNAs disappear, says Galenko.

"We need to do additional research with more samples, but we've found a pattern that may help us understand the factors that lead to a heart attack, and we've developed a lot more questions that further research will help answer," she says.

"Ultimately, our goal is to develop a test that predicts when a heart attack is going to occur in patients with heart disease," Galenko adds. "This would help physicians intervene proactively and stop heart attacks from happening. There are monitors people wear that detect blood chemistry, and if we really wanted to look into the future, perhaps we could develop something similar, something people who are at risk for a heart attack could wear to monitor these microRNAs."


'/>"/>

Contact: Jess C. Gomez
jess.gomez@imail.org
801-718-8495
Intermountain Medical Center
Source:Eurekalert

Related biology news :

1. Erasing a genetic mutation
2. Genetic mutations warn of skin cancer risk
3. Drilling into the trends in genetics and epigenetics of aging and longevity
4. Faster genetic testing method will likely transform care for patients with breast cancer
5. Genetics can explain why infections can trigger rheumatoid arthritis
6. Certain genetic variants may put bladder cancer patients at increased risk of recurrence
7. MRI reveals genetic activity
8. UT Southwestern ob/gyn researchers studying genetic factors in premature births
9. Researchers issue state-of-the-state on genetic-based testing & treatment for breast cancer
10. TGen-led study discovers genetic cause of rare type of ovarian cancer
11. Genetic testing may help select women with ER+ breast cancer for extended hormone therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... 24, 2016 Ampronix facilitates superior patient care by providing unparalleled technology to ... display is the latest premium product recently added to the range of products distributed ... ... ... Imaging- LCD Medical Display- Ampronix News ...
(Date:5/12/2016)... -- WearablesResearch.com , a brand of Troubadour Research ... the Q1 wave of its quarterly wearables survey. A ... to a program where they would receive discounts for ... "We were surprised to see that so ... , CEO of Troubadour Research, "primarily because there are ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 /PRNewswire/ ... product subsidiary of Infosys (NYSE: INFY ), and ... global partnership that will provide end customers with ... banking and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... area for financial services, but it also plays a fundamental ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... 27, 2016  Liquid Biotech USA ... of a Sponsored Research Agreement with The University ... (CTCs) from cancer patients.  The funding will be ... correlate with clinical outcomes in cancer patients undergoing ... then be employed to support the design of ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)...   Boston Biomedical , an industry leader ... target cancer stemness pathways, announced that its lead ... Designation from the U.S. Food and Drug Administration ... gastroesophageal junction (GEJ) cancer. Napabucasin is an orally ... stemness pathways by targeting STAT3, and is currently ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology: