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Genetic marker linked to problem behaviors in adults with developmental disabilities
Date:7/21/2009

of problem behavior, those with the disabilities but without problem behavior, and a typically developing control group. Only white men were sampled because the MAOA gene is linked to the X chromosome and also is shown to vary by ethnicity.

Forty-three percent of those with developmental/intellectual disabilities and behavior problems had the gene variant, compared to 20 percent of the same group with no behavior issues and 20 percent of a typically developing control group.

The same MAOA variation has also been linked to autism in children, autism severity and communication problems. The researchers suggest that problem behaviors linked to this variation may explain increased autism severity in individuals with it. It is not, however, linked to behavior problems in individuals with fragile X syndrome, pointing to the need for further research on genetic and other contributors to problem behavior in individuals with different developmental disabilities.


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Contact: Melanie Moran
melanie.moran@vanderbilt.edu
615-322-7970
Vanderbilt University
Source:Eurekalert

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