Navigation Links
Genetic irregularities linked to higher risk of COPD among smokers
Date:3/19/2009

DURHAM, N.C. Scientists at Duke University Medical Center have discovered two genetic markers that appear to put some smokers at significantly higher risk of developing chronic obstructive pulmonary disease (COPD).

The findings come from the first-ever genome-wide association study of COPD and suggest that those who carry the markers may be able to reduce their risk if they quit smoking before the first symptoms of COPD occur.

"The public health message would probably be 'quit before it's too late,'" says David Goldstein, Ph.D., director of the Institute for Genome Sciences Center for Human Genome Variation at Duke and the senior author of the study appearing in PLoS Genetics.

Chronic obstructive pulmonary disease is one of the leading causes of death worldwide. While smoking is the biggest risk factor, there is considerable variation among those who develop the disease. Genetics plays a role, but until now, there has only been one biological marker proven to be associated with COPD a deficit of the protein A1AT, which has also been linked to the development of lung cancer.

"But we know that A1AT deficiency appears in only 1-2 percent of people with COPD, so we were pretty sure that there had to be other genetic variants at work, as well," says Goldstein.

To discover if that hunch might prove true, Goldstein led an international team of investigators in examining the genomes of 823 people with COPD and 810 smokers without COPD in Norway. They were looking for the presence of the 100 top genetic variations already documented in individuals with COPD enrolled in the family-based International COPD Genetics Network. They then took the most frequently occurring alterations from that study and evaluated them in three additional, independent groups: patients in the U.S. National Emphysema Treatment Trial, individuals enrolled in the Boston Early-Onset COPD study and a control group from the Normative Aging S
'/>"/>

Contact: michelle.gailiun@duke.edu
michelle.gailiun@duke.edu
919-724-5343
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers identify genetic markers for aggressive head and neck cancer
2. Symposium to look at genetic basis of exercise
3. Genetic abnormality may increase risk of blood disorders
4. Researchers take first look at the genetic dynamics of inbreeding depression
5. The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders
6. Cats eye diseases genetically linked to diseases in humans
7. Genetic study finds treasure trove of new lizards
8. New potential therapeutic target discovered for genetic disorder -- Barth syndrome
9. Autism Speaks funds $5 million to studies on genetic and environmental risk factors for autism
10. Study examining role of genetics and environment in type 1 diabetes
11. Predicting risk of stroke from ones genetic blueprint
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... , March 12, 2015 The mascots of ... Children,s Hospital, part of Wake Forest Baptist Medical Center. ... for the 2015 ACC Men,s Basketball Tournament. Young patients ... them and getting their autographs. Brenner Children,s ... It is the only children,s hospital in northwest ...
(Date:3/11/2015)... 11, 2015 Research and Markets ( ... "Access Control Market by Product, Application & By Geography ... to their offering. , This report predicts ... $10.4 billion by 2020, with an estimated CAGR of ... the products types such as contact cards & readers, ...
(Date:3/10/2015)... BOULDER, Colo. , March 10, 2015 ... Space Flight "Personalized Medicine in Human ... Ph.D. and Thomas J. Goodwin , Ph.D. was ... articles of the past two years. Specifically, ... three most downloaded scientific papers published in 2013 and ...
Breaking Biology News(10 mins):Global Access Control (Cards & Readers, Biometrics, Controllers, Management Software) Market 2015-2020 - Analysis of the $10 Billion Market 2"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2
... In this week's Analytical Chemistry, scientists at Indiana ... sperm cells to follow the weakest of scents. ... some sperm cells still found their mark. , ... response to a chemical gradient) can be downloaded ...
... predict which smokers using the nicotine patch are likely to ... probability of success in quitting cigarettes, according to the results ... of Clinical Pharmacology and Therapeutics. , The blood ... nicotine is metabolized, may eventually be performed non-invasively using saliva ...
... Unlike the Three Musketeers who lived by the motto ... to do their own thing. For years, debate swirled ... on a central growth regulatory module. Now, the cooperation ... for Biological Studies. They show that each hormone acts ...
Cached Biology News:Even when faint, ovary scent draws sperm cells 2Blood test predicts success of quitting smoking using the nicotine patch 2Computational analysis shows that plant hormones often go it alone 2Computational analysis shows that plant hormones often go it alone 3
(Date:3/26/2015)... (PRWEB) March 26, 2015 "In America," the ... the United States that is hosted by legendary film actor ... topic of botany in an upcoming segment. , Botany ... in reality it is actually quite a bit more complicated ... of different types of living organisms, from the smallest bacteria ...
(Date:3/25/2015)... pharmaceutical market is one of the most attractive ... absolute size, plus a growing economy and increasing government ... Monitor International. The Russian market is set to grow ... with growth estimates around 10-15% annually reaching an approximate ... About Green Cross Green Cross provides total ...
(Date:3/25/2015)... -- Optimal Research, LLC has been nominated as a ... Clinical Site or Trial Network". This is ... as a nominee in this ViE award category at ... in 2014. The ViE awards were created to honor ... contributions of companies and individuals in the vaccine industry. ...
(Date:3/25/2015)... March 25, 2015 Laboratory workers ... Balances and Analytical Balances to get best-performing features ... of weighing balances from the trusted brand include: ... increase your efficiency by providing a large ... samples. Weighing modes include parts counting, percent weighing, ...
Breaking Biology Technology:Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2New Economical Top-Loading and Analytical Symmetry Balances from Cole-Parmer 2
... Healthcare Distribution Management Association (HDMA), the national association representing ... association as Senior Vice President of Government Affairs. In ... federal and state legislative and regulatory initiatives. ... array of evolving laws and regulations that have a ...
... Jan. 4, 2011 When pregnant women need medications, ... fetus. Although some drugs are clearly recognized to cause ... are generally recognized as safe, surprisingly little is known ... Children,s Hospital Boston Informatics Program (CHIP) have created a ...
... Neogen Corporation (Nasdaq: NEOG ) announced today that ... which ended Nov. 30, increased 33% from the previous year,s ... or $0.26 per share, compared to the prior year,s $0.20. ... to the prior year,s $35,251,000. Year-to-date revenues for the first ...
Cached Biology Technology:Healthcare Distribution Management Association Names Patrick Kelly New Senior Vice President, Government Affairs 2Model Predicts a Drug's Likelihood of Causing Birth Defects 2Model Predicts a Drug's Likelihood of Causing Birth Defects 3Neogen Reports 33% Increase in Net Income 2Neogen Reports 33% Increase in Net Income 3Neogen Reports 33% Increase in Net Income 4Neogen Reports 33% Increase in Net Income 5
Mouse monoclonal antibody raised against a full length recombinant LDB3. NCBI Entrez Gene ID = LDB3...
...
Mouse monoclonal antibody raised against a partial recombinant WDR5. NCBI Entrez Gene ID = WDR5...
... Polyclonal Antibody against Nonmuscle Myosin II ... Antibody (Stored in TBS + 0.03% ... the peptide SDVNETQPPQSE corresponding to the ... isoform B (MHC-B) This antibody is ...
Biology Products: