Navigation Links
Genetic function discovered that could offer new avenue to cancer therapies
Date:2/3/2014

n of cancers."

But the activity and function of p53 can sometimes decline or fail, Leid said, and allow development of cancer. Promising approaches to cancer therapy are now based on activating or stimulating the p53 protein to do its job.

The new study has found that the Grasp gene is significantly involved in maintaining the proper function of p53. When "Grasp" is not being adequately expressed, the p53 protein that has entered the cell nucleus to either repair or destroy the cell comes back out of the nucleus before its work is finished.

"It appears that a primary function of Grasp is to form sort of a halo around the nucleus of a damaged skin cell, and act as kind of a plug to keep the p53 cell inside the nucleus until its work is done," Leid said. "A drug that could enhance Grasp function might also help enhance the p53 function, and give us a different way to keep this important tumor suppressor working the way that it is supposed to.

"This could be important," he said.

OSU experts created laboratory mice that lacked the Grasp gene, and so long as the mice were reared in a perfect environment, they developed normally. But when they were exposed to even a mild environmental stress ultraviolet light similar to moderate sun exposure they began to develop cellular abnormalities much more rapidly than ordinary mice. Most significantly, mutated skin cells did not die as they should have.

In normal mice, the same moderate light exposure caused a rapid increase in expression of the Grasp gene, allowing the p53 protein to stay in the nucleus and normal protective mechanisms to do their work.

Most current cancer therapies related to the p53 tumor suppression process are directed toward activating the p53 protein, Leid said. A therapy directed toward improving the Grasp gene function would be a different approach toward the same goal, he said, and might improve the efficacy of treatment.


'/>"/>
Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Dartmouth researchers develop new tool to identify genetic risk factors
2. Genetics Society of America selects 5 geneticists to receive societys 2014 Awards
3. David Allis, pioneer in epigenetics, to receive prestigious Japan Prize
4. 23andMe helps identify 11 new genetic associations for asthma-with-hay fever
5. Scientists find genetic mechanism linking aging to specific diets
6. Genomics for judges: Educating Illinois judges on how genetic info impacts court decisions
7. Complimentary press registration now open for ACMG 2014 Annual Clinical Genetics Meeting
8. Toddlers aggression is strongly associated with genetic factors
9. Important discovery for the diagnosis of genetic diseases
10. First comprehensive test to detect genetic modification in food
11. Multiple myeloma study uncovers genetic diversity within tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... In a paper published online today in the journal ... Northeastern researchers Evan Kodra and Auroop Ganguly found that ... the variability in temperature extremes. For instance, while each ... those averages will also tend to fall within a ... than are currently being observed. This means that even ...
(Date:7/29/2014)... warms and sea ice retreats, the North is changing. ... open water which is predicted to extend across the ... Storms thus have the potential to create Arctic swell ... unpredictable element to the region. , A University of Washington ... middle of the Arctic Ocean, and detected house-sized waves ...
(Date:7/29/2014)... Research and Markets  has announced the ... Market 2014-2018" report to their offering. ... term BI refers to applications and technologies that are ... about a company,s operations. BI help organizations to acquire ... example, metrics on sales, production, and internal operations. ...
Breaking Biology News(10 mins):Big data confirms climate extremes are here to stay 2Huge waves measured for first time in Arctic Ocean 2Huge waves measured for first time in Arctic Ocean 3Global SaaS-based Business Intelligence (BI) Market 2014-2018 2
... turmeric packs more than just flavor it shows ... Curcumin, found in turmeric, stopped the potentially ... cells, says Aarthi Narayanan, lead investigator on the new ... Center for Biodefense and Infectious Diseases. Mosquito-borne Rift ...
... COLUMBUS, Ohio - Almost 41 percent of Ohioans have visited ... the past year, and of those, nearly one-half usually spend ... findings in a new report. These figures and other ... lakes and rivers, and particularly Lake Erie, as natural resources, ...
... tale of your family line. It carries the genetic history ... Tel Aviv University researcher, it,s also possible to use it ... Halperin of TAU,s Blavatnik School of Computer Science and Department ... researchers from University of California, Los Angeles, are giving new ...
Cached Biology News:Turmeric spices up virus study 2Turmeric spices up virus study 3Ohioans love their lakes, but are concerned for their future 2Ohioans love their lakes, but are concerned for their future 3Ohioans love their lakes, but are concerned for their future 4A GPS in your DNA 2
(Date:7/30/2014)... 2014 With the accelerated aging ... health expenditure as well as the improved medical ... diagnostic reagent industry has been developing quickly, especially ... 2013, Chinese in vitro diagnostics market size reached ... in vitro diagnostic reagents. , Read complete ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 BCC Research ... Global Markets for Enzymes in Industrial Applications , the ... to nearly $7.1 billion by 2018, registering a five-year ... is estimated to be recorded in the detergent enzyme ... period. , Enzyme technology has influenced almost every sector ...
(Date:7/30/2014)... AZ (PRWEB) July 30, 2014 ... State-of-the-art facility and complementary therapies brings comprehensive cancer ... foot, state-of-the-art Yuma Regional Cancer Center has officially ... 2012, the program includes services such as open, ... massage therapy, American Cancer Society Resource Center, hematology, ...
(Date:7/30/2014)... , July 30, 2014  Dyadic International, ... company whose patented and proprietary technologies are used ... other proteins for the bioenergy, bio-based chemical, biopharmaceutical ... of Thomas "Tom" Dubinski as Vice President and ... leading the financial and information technology operations for ...
Breaking Biology Technology:China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 2China Diagnostic Reagent Industry Report, 2013-2016 | Researchmoz 3Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Sate-of-the-Art Yuma Regional Cancer Center Officially Opens 2Thomas Dubinski joins Dyadic as Chief Financial Officer 2Thomas Dubinski joins Dyadic as Chief Financial Officer 3Thomas Dubinski joins Dyadic as Chief Financial Officer 4
... Street Healthcare Partners , a strategic private equity firm ... Garrett has joined the firm as an operating partner. ... executive officer of Beckman Coulter, Inc., brings to Water ... care businesses ranging from diagnostics and life sciences to ...
... Fresh®, Inc., maker of the popular FireFly® children,s light-up ... raise awareness and funds for Smile Train, the world,s ... will donate $1 for every new "Like" on ... Train.  The organization provides life-changing surgery for poor children ...
... Gilliam, a famed Hollywood actor and former Golden Gloves ... line of nutritional products. Bubba, who once worked with ... Eastwood, Gene Wilder, Andy Griffith, Jeff Bridges, Hilary Swank, ... Fox, Willie Nelson and more, says, "I,ve never slept ...
Cached Biology Technology:Scott Garrett Joins Water Street Healthcare Partners 2Scott Garrett Joins Water Street Healthcare Partners 3FireFly® Toothbrush Facebook Campaign Raises Funds for Smile Train 2Terra Biotech Goes Hollywood with New Endorsement Burton 'Bubba' Gilliam 2
...
Antibodies were affinity purified using epitopes specific to QKI immobilized on solid support....
Acrylamide, 500 g. Assay: > 99.9%, acrylic acid: < 0.001%. Conductivity (35%): < 2 umhos/cm.Risks: 45, 46, 48, 23, 24, 25 ; Safety Precautions: 53, 44. Category: Nucleotides & Enzymes & Biochemicals...
Assay Diluent Trial Pack, 4 x 100 mL...
Biology Products: