Navigation Links
Genetic function discovered that could offer new avenue to cancer therapies
Date:2/3/2014

n of cancers."

But the activity and function of p53 can sometimes decline or fail, Leid said, and allow development of cancer. Promising approaches to cancer therapy are now based on activating or stimulating the p53 protein to do its job.

The new study has found that the Grasp gene is significantly involved in maintaining the proper function of p53. When "Grasp" is not being adequately expressed, the p53 protein that has entered the cell nucleus to either repair or destroy the cell comes back out of the nucleus before its work is finished.

"It appears that a primary function of Grasp is to form sort of a halo around the nucleus of a damaged skin cell, and act as kind of a plug to keep the p53 cell inside the nucleus until its work is done," Leid said. "A drug that could enhance Grasp function might also help enhance the p53 function, and give us a different way to keep this important tumor suppressor working the way that it is supposed to.

"This could be important," he said.

OSU experts created laboratory mice that lacked the Grasp gene, and so long as the mice were reared in a perfect environment, they developed normally. But when they were exposed to even a mild environmental stress ultraviolet light similar to moderate sun exposure they began to develop cellular abnormalities much more rapidly than ordinary mice. Most significantly, mutated skin cells did not die as they should have.

In normal mice, the same moderate light exposure caused a rapid increase in expression of the Grasp gene, allowing the p53 protein to stay in the nucleus and normal protective mechanisms to do their work.

Most current cancer therapies related to the p53 tumor suppression process are directed toward activating the p53 protein, Leid said. A therapy directed toward improving the Grasp gene function would be a different approach toward the same goal, he said, and might improve the efficacy of treatment.


'/>"/>
Contact: Mark Leid
mark.leid@oregonstate.edu
541-737-5809
Oregon State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Dartmouth researchers develop new tool to identify genetic risk factors
2. Genetics Society of America selects 5 geneticists to receive societys 2014 Awards
3. David Allis, pioneer in epigenetics, to receive prestigious Japan Prize
4. 23andMe helps identify 11 new genetic associations for asthma-with-hay fever
5. Scientists find genetic mechanism linking aging to specific diets
6. Genomics for judges: Educating Illinois judges on how genetic info impacts court decisions
7. Complimentary press registration now open for ACMG 2014 Annual Clinical Genetics Meeting
8. Toddlers aggression is strongly associated with genetic factors
9. Important discovery for the diagnosis of genetic diseases
10. First comprehensive test to detect genetic modification in food
11. Multiple myeloma study uncovers genetic diversity within tumors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... cases in Sierra Leone showed that about two-thirds of ... and nearly nine percent tested positive for Ebola virus. ... Emerging Infectious Diseases , demonstrates that Ebola virus has ... before the current outbreak. , First author Randal J. ... where he spent six weeks helping to set up ...
(Date:7/14/2014)... in the local environment manage much better in the ... environments. , A world without bees would be ... an additional 600 million to 1 billion Danish kroner ... bees making honey and pollinating a wide range of ... bees all over the world are under pressure from ...
(Date:7/14/2014)... consequence of aging? , Although it is widely thought ... risk of developing several common cancers decreases with age. ... decrease with age in the risk of developing certain ... puzzle was presented in a recent paper published in ... P. Brody of the Department of Biomedical Engineering at ...
Breaking Biology News(10 mins):Sierra Leone samples: Ebola evidence in West Africa in 2006 2Sierra Leone samples: Ebola evidence in West Africa in 2006 3Best for bees to be stay-at-homes 2
... in decks, utility poles and fences will likely leach ... groundwater, according to two research papers published online Wednesday. ... of Florida and Florida International University examined arsenic leaching ... real deck as well as from simulated landfills. , ...
... using MRI to detect magnetic probes of tiny iron ... time has successfully tracked immune-stimulating cells implanted into cancer ... the eight patients, MRI revealed that the implanted cells ... for treatment," says Jeff Bulte, Ph.D., an associate professor ...
... chicken when she crossed the road is less important that what ... , Organic arsenic is fed to poultry to prevent bacterial infections ... up by the tissue and the majority of it is excreted ... urine from under poultry houses -- is rich in nitrogen and ...
Cached Biology News:Researchers: Treated wood poses long-term threat 2Researchers: Treated wood poses long-term threat 3Magnetic probe successfully tracks implanted cells in cancer patients 2Magnetic probe successfully tracks implanted cells in cancer patients 3Geoscientists follow arsenic from chicken feed to streambeds 2
(Date:7/10/2014)... Senior supply chain management executives from over 50 ... of “Reducing Cost, Lead Time, & Defects in the ... the partnership of the Bio Supply Management Alliance ( ... SCMI) of the University of San Diego in ... Institute of Peace and Justice in San Diego, Devendra ...
(Date:7/10/2014)... 2014 On July 9 Prime ... presented Russia,s first national "Industry" ... Company is developing a unique project called MabNext ... a number of innovative drugs based on monoclonal antibodies ... took place at the International Exhibition "Innoprom 2014" in ...
(Date:7/10/2014)... PROVO, Utah , July 10, 2014 ... genome annotation and interpretation, today announced an ... sequencing (NGS) analytics for Lineagen,s NextStep Dx ... evaluation of neurodevelopmental and neurological disorders, currently ... chromosomal microarray (CMA) testing service used by ...
(Date:7/10/2014)... July 10, 2014   Ceres, Inc . (Nasdaq: ... company, announced today financial results for the three months ... its business. Ceres reported that the company ... performance this growing season in Brazil, which concluded in ... company,s sorghum evaluation areas for part of the growing ...
Breaking Biology Technology:Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 2Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 3Tute Genomics Platform Selected to Provide Clinical Interpretation for Lineagen's NextStepDx PLUS Next-Generation Sequencing-Based Diagnostic Test 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9
... ... Hermes Biosciences and partnership with sanofi-aventis , ... Cambridge, MA (PRWEB) April 7, 2010 -- Merrimack Pharmaceuticals, Inc., ... for cancer and inflammation, today announced that William Sullivan has been promoted to Vice ...
... have found a way to turn a precision measurement device ... researchers adapted a device known as an optical frequency comb ... data operations that will be vital for future quantum computers. ... Review Letters and is described in a Viewpoint article ...
... ... to build and sell "Flexible Fuel" cars, as would be required by ... the impact of the stricter fuel efficiency standards announced today by President ... President,s announcement, advocates of energy independence challenged the President to show his ...
Cached Biology Technology:Merrimack Pharmaceuticals Promotes William Sullivan to Vice President of Finance 2Challenge President to Adopt Energy Measure with Double the Impact of Improved Auto Fuel Efficiency Standards at Fraction of the Cost 2
Agarose, pulse field, 250 g. Nuclease-free.Gel point (1.5%): 36 1.5 C, EEO (-mr): 1800 g/cm2. Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
100 adhesive strips....
Request Info...
Molecular Biological Resources has extensive abilities cloning and expression of prokaryotic and eukaryotic proteins. Please contact lloconne@molbiores.com to discuss your project. Contact lloconne@...
Biology Products: