Navigation Links
Genetic finding could lead to targeted therapy for neuroblastoma
Date:6/24/2009

series of papers that creates the bigger picture, an understanding of the genetic mechanisms that lead to neuroblastoma," said London, the principal investigator for the Children's Oncology Group Statistics and Data Center at UF. "We are searching for genetic targets to treat with therapy."

The researchers reported additional genetic links in Nature Genetics in May. The team discovered that on the gene called BARD1, six single-nucleotide polymorphisms variations in tiny pieces of DNA were also associated with neuroblastoma.

"Only two years ago we had very little idea of what causes neuroblastoma," said Maris, who led both studies. "Now we have unlocked a lot of the mystery of why neuroblastoma arises in some children and not in others."

Although neuroblastoma is one of the more common childhood cancers, it is relatively rare overall when compared with more common adult cancers, which has proved to be a challenge for researchers trying to uncover its causes, said Peter Zage, M.D., Ph.D., an assistant professor of pediatrics at the Children's Cancer Hospital at the University of Texas M.D. Anderson Cancer Center.

"Dr. Maris' group has been able to collect a relatively large number of cases for a neuroblastoma study and so has been able to identify these genetic variations and specific genes to provide us with some new avenues for therapy that we probably would not have been able to identify looking at the smaller cohorts of patients we each see at our individual institutions. In that sense, it's certainly an amazing leap forward in our understanding of the disease."

The discovery does hold promise for developing treatments, but London cautions that these potential "targeted therapies" won't work on all neuroblastoma patients. Not all neuroblastoma patients have this particular genetic anomaly, and not all children with this anomaly will develop neuroblastoma. Development of neuroblastoma is complicated and can occur b
'/>"/>

Contact: April Frawley Birdwell
afrawley@ufl.edu
352-273-5817
University of Florida
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related biology news :

1. New piece found in the puzzle of epigenetics
2. Aussie and Kiwi researchers make double MS genetic discovery
3. Specific genetic cause of fetal alcohol-related developmental disorders found
4. Horse whisperers, lion tamers not needed: Scientists find genetic regions that soothe savage beasts
5. Geography and history shape genetic differences in humans
6. Scientists discover new genetic immune disorder in children
7. Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients
8. Penn researchers discover genetic risk factor for testicular cancer
9. Combined stem cell-gene therapy approach cures human genetic disease in vitro
10. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
11. UF makes gene therapy advance in severe genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Northwest National Laboratory honored more than 165 staff ... property at PNNL,s annual Intellectual Property Commercialization Recognition ... of Energy national laboratory named materials scientist Jun ... developing battery materials that can store large amounts ... and reduce the time it takes to charge ...
(Date:5/23/2013)... estrogen suppresses lipid synthesis in the liver, UC Irvine ... certain liver diseases. , With this finding, Dr. ... views in the field. Study results appear in the ... . , "The dogma in the steroid receptor field ... in the nucleus respond to steroid hormones by regulating ...
(Date:5/23/2013)... unnecessarily undergo surgery or harsh treatments because science ... aggressive forms of the disease. Researchers at Case ... are developing technology that allows patients to safely ... treatments or take drastic measures. , The project ... professor of biomedical engineering at Case Western Reserve ...
Breaking Biology News(10 mins):PNNL staff recognized for scientific accomplishments, moving technologies into the marketplace 2UCI study reveals new mechanism for estrogen suppression of liver lipid synthesis 2Using big data to identify prostate cancers and best treatments 2Using big data to identify prostate cancers and best treatments 3
... the event of a smallpox outbreak in the United States, ... national studye to start protecting Americans by stimulating an immune ... Louis University School of Medicine will attempt to answer this ... in the United States in 1971, and the world was ...
... alarmed that the government of The Gambia is encouraging ... in order to try an unproven herbal remedy. The ... to cease his unproven claims that the treatment "cures" ... applying his treatment to a handful of patients who ...
... is melting at a significantly faster rate than projected ... study concludes. The research, by scientists at the National ... Colorado's National Snow and Ice Data Center (NSIDC), shows ... than estimated by any of the 18 computer models ...
Cached Biology News:Smallpox outbreak: How long would it take for vaccines to protect people? Would it work? 2HIVMA opposes The Gambia's unproven AIDS remedy 2Arctic ice retreating more quickly than computer models project 2Arctic ice retreating more quickly than computer models project 3
(Date:5/23/2013)... , May 23, 2013  Rahal Letterman Lanigan ... human cord blood stem cell banking and therapeutics, announced ... the No. 16 Acorn Stairlifts Indy car driven by ... the remainder of the IZOD IndyCar 2013 season.   ... will work to support awareness of umbilical cord blood ...
(Date:5/23/2013)... PI’s new LPS-24 positioners are less ... travel range with closed-loop sensor resolution up to ... new positioners the ideal choice for high precision ... is also available. , More Information: Specifications ... found at: , http://www.physikinstrumente.com/en/products/prdetail.php?sortnr=1000745&prw-lps24 , Reference-Class ...
(Date:5/23/2013)... Calif. , May 23, 2013  Saddleback Memorial ... recently became the first hospital on the West ... technology. This new surgical option provides women with a ... Marc Winter , M.D., a ... and surgeon and medical director of minimally invasive surgery ...
(Date:5/23/2013)... EXTON, Pa. , May 23, 2013 /PRNewswire/ ... leading research and advisory firms for specialized biopharmaceutical ... gastroenterologists, hepatologists, and infectious disease specialists reported that ... warehousing patients (e.g., intentionally delaying treatment) in anticipation ... physicians than six months ago, when only 6 ...
Breaking Biology Technology:StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3Precision Positioning System Uses Miniaturezed Piezo Linear Motor: LPS-24 Linear Stage by PI 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3
... HOBOKEN, N.J., Dec. 2 According to the National Institute of ... already have some stage of diabetic retinopathy. Diabetic retinopathy, damage ... cause of blindness in people with diabetes and is one of ... percent of all patients who,ve had diabetes for 10 years or ...
... Nev., Dec. 1 PDL BioPharma, Inc. (PDL) (Nasdaq: ... ended December 31, 2009 of approximately $57 million, as compared ... in fourth quarter 2008 results was the first of two ... in fourth quarter 2008 results was a one-time $1.8 million ...
... , NEW ... market research report is available in its catalogue: , ... , http://www.reportlinker.com/p0164431/Industrial-Enzymes---A-Global-Market-Report.html , Industrial Enzymes market is ... of small suppliers engaged in niche market activities. Keen ...
Cached Biology Technology:Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 2Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 3Study Shows Pine Bark Improves Microcirculation, Retinal Swelling And Visual Acuity In Early Diabetic Retinopathy 4PDL BioPharma Provides Fourth Quarter 2009 Revenue Guidance of Approximately $57 Million 2PDL BioPharma Provides Fourth Quarter 2009 Revenue Guidance of Approximately $57 Million 3Reportlinker Adds Industrial Enzymes - A Global Market Report 2Reportlinker Adds Industrial Enzymes - A Global Market Report 3Reportlinker Adds Industrial Enzymes - A Global Market Report 4Reportlinker Adds Industrial Enzymes - A Global Market Report 5Reportlinker Adds Industrial Enzymes - A Global Market Report 6Reportlinker Adds Industrial Enzymes - A Global Market Report 7Reportlinker Adds Industrial Enzymes - A Global Market Report 8Reportlinker Adds Industrial Enzymes - A Global Market Report 9Reportlinker Adds Industrial Enzymes - A Global Market Report 10