Navigation Links
Genetic factors may predict depression in heart disease patients
Date:5/19/2009

ed States.

The current study focused on 977 patients with cardiovascular disease who had either a 50 percent or higher blockage in at least one major coronary artery or a documented heart attack. Of these patients, 21 percent were female and the average age was 59 years. Symptoms of depression were measured using a standardized self-reported questionnaire recommended by the National Heart, Lung and Blood Institute (NHLBI).

Researchers targeted 59 different candidate genes because of their relevance to a biological pathway of interest or their prior association with depression in medical literature. The genes include those related to inflammation; platelet aggregation, or clumping; endothelial function involving the cells that line the inner surface of blood vessels; and omega-3 fatty acid metabolism, which can affect the hardening of the arteries.

Following genotyping and statistical analyses, the research team discovered that genetic variations involving endothelial dysfunction a hallmark for vascular diseases, such as atherosclerosis and platelet aggregation appear to contribute to depressive symptoms.

Specifically, they identified one marker within the vonWillebrand factor (vWF) gene that appears to have a significant association. vWF is a protein produced by the endothelium that is critical to the initial stages of blood clotting by helping platelets stick to damaged blood vessels. When elevated in concentration, VWF is a strong predictor of endothelial dysfunction and a risk factor for atherosclerosis.

"Although further study is needed, our findings suggest that endothelial dysfunction may be a novel mechanism contributing to depressive symptoms among heart disease patients," said McCaffery, who is also an assistant professor of psychiatry and human behavior at The Warren Alpert Medical School of Brown University.

Researchers note that the candidate gene approach used in the study is limited by the cu
'/>"/>

Contact: Jessica Collins Grimes
jgrimes2@lifespan.org
401-793-7484
Lifespan
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Does the desire to consume alcohol and tobacco come from our genetic makeup?
2. Diverse genetic abnormalities lead to NF-κB activation in multiple myeloma
3. Many parents at-risk for cancer disclose genetic test results to children
4. Genetics determine optimal drug dose of common anticoagulant
5. Claims of sex-related differences in genetic association studies often not properly validated
6. American College of Medical Genetics responds to new FDA labeling decision for warfarin
7. UNC study questions FDA genetic-screening guidelines for cancer drug
8. Genome study shines light on genetic link to height
9. Selexis Announces Advanced Approach to Maximize Power of Genetic Elements for Rapid Development of High Performance Cell Lines
10. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
11. Rutgers Genetics receives $7.8 million for autism research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 3, 2014 According to ... Type (Swipe And Area), Material (Optical Prism, Pizeoelectric, Capacitive, ... Security and Banking & Finance), and Geography - Global ... MarketsandMarkets, the global Fingerprint Sensors Market is projected to ... CAGR of 16.8% from 2014 to 2020. ...
(Date:7/10/2014)... Fingerprint Cards, (FPC,s) new mobile touch sensor FPC1021 ... Top 5 smartphone OEM has selected FPC1021 for a flagship ... 2014.   FPC is proud to announce this ... a planned date for the start of mass production in ... of 3 million units. The Chinese OEM wants to remain ...
(Date:7/10/2014)... 2014 Fingerprint Cards, (FPC,s) ... win (DW). An Asian OEM has selected FPC1021 for a ... in August 2014.   FPC is proud to ... a planned date for start of mass production in August ... SEK 5M, for delivery in the first half of July. ...
Breaking Biology News(10 mins):Fingerprint Sensors Market worth $14.35 Billion by 2020 2Fingerprint Sensors Market worth $14.35 Billion by 2020 3FPC Wins DW for 1021 Touch Sensor for Flagship Smartphone from Chinese Top 5 Smartphone OEM 2FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... School of Medicine has revealed key features in ... and other extreme environments. The researchers, funded by ... environment of Antarctica. They found subtle but significant ... and Haloarchaea, organisms that can tolerate severe conditions ...
... that pumpkins and cucumbers can be traced back to India. ... of Cucurbitaceae evolution and diversity, a new checklist of the ... that family. The study was published in the open access ... components of a healthy daily diet, not just in India ...
... of continuing evolution in the college textbook market, an ... leader (NYSE:JWa, JWb), and Rice University-based OpenStax College, a ... partnership calls for Wiley to deliver content from OpenStax ... online learning, practice and assessment resources that are ...
Cached Biology News:University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars 2A new checklist confirms Indian origins of pumpkins and cucumbers 2Unlikely partners create innovative product for college biology 2
(Date:7/13/2014)... 2014 Deep Research Report on Global and ... study on the current state of the Nano Silver ... a basic overview of the industry, including definitions, applications ... domestic market analysis are provided with a focus on ... A comparison between the international and Chinese situation is ...
(Date:7/11/2014)... PALM BEACH, Fla. , July 11, 2014 /PRNewswire-iReach/ ... variety of high-quality peptides that are used solely in ... To honor two successful years in business, Maxim Peptide, ... LLC, has just launched a new and updated website ... the research blog section has been updated with fascinating ...
(Date:7/11/2014)... July 11, 2014 Research and Markets ... Technology Market - Global Industry Analysis, Size, Share, Growth, ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... acids (either DNA or RNA) into cells. This technology ... cancer cells and protein metabolism by affecting the nuclear ...
(Date:7/11/2014)... July 11, 2014 EPFL and ... the appointment of John P. Donoghue . The ... Geneva . The new Wyss ... in Geneva , has named as ... John P. Donoghue , founder of Brown University,s ...
Breaking Biology Technology:2014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 22014 Nano Silver Industry in Global and China Regions Development Proposals Analysis Available at DeepResearchReports.com 3Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3
... a simple and convenient technique that combines nanoscale ... elusive goal. With current analytical instruments, spatial resolution ... preparation too complex or sample size too large ... the University of Illinois have demonstrated a method ...
... LAKES, N.J., March 27 BD (Becton,Dickinson and ... medical technology,company, and Direct Relief International, a humanitarian ... volunteer,initiative to strengthen healthcare in Ghana. A team ... Ghana for three weeks and work side-by-side,with Direct ...
... (Nasdaq: GNTA ) announced that the NASDAQ ... an extension of,time to achieve full compliance with ... decision, the listing of the,Company,s common stock will ... NASDAQ Capital Market, effective with the open of ...
Cached Biology Technology:Femtogram-level chemical measurements now possible, U. of I. team reports 2BD and Direct Relief International Launch Second Volunteer Service Trip to Improve Healthcare in Ghana 2BD and Direct Relief International Launch Second Volunteer Service Trip to Improve Healthcare in Ghana 3Genta Granted Extension to Achieve Compliance with NASDAQ Listing Requirements 2Genta Granted Extension to Achieve Compliance with NASDAQ Listing Requirements 3
Recombinant Rhesus Macaque IFN-alpha...
... 500 g protein in 200 l SDS-PAGE ... cell lysate; Abelson transformed macrophage cells, ... positive control, should be stored ... be minimized, sample vial should ...
The epitope is specific for TASK and is not present in any other known proteins tested so far.,SPECIES REACTIVITIES: The epitope is also highly conserved between mouse and rat (17/18 residues iden...
Anti-Mouse MIP-1g, Biotin (Polyclonal) (rabbit IgG)...
Biology Products: