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Genetic factors can predict the progression of Parkinson's disease
Date:12/16/2011

1H1 genotype with two NACP-Rep1 '0's. In contrast there was a high risk of a fast clinical progression in patients carrying MAPT H1H1 genotype with two or no NACP-Rep1 '0's.

"Based on current knowledge, it is perhaps not surprising that genetic variation predisposing to high a-synuclein expression gives rise to more rapid progression of PD," notes Dr. Huang. "However, our results suggest that low α-synuclein expression may also be as detrimental in people with high tau expression levels, calling into question the concept that reducing neuronal α-synuclein in all PD patients may be therapeutically advantageous."


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Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

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