Navigation Links
Genetic discovery found to influence obesity in people of African ancestry
Date:4/15/2013

LOUISVILLE, Ky. The largest genetic search for "obesity genes" in people of African ancestry has led to the discovery of three new regions of the human genome that influence obesity in these populations and others.

University of Louisville School of Public Health and Information Sciences Department of Epidemiology and Population Health researcher Kira Taylor, PhD, and her team today (April 14, 2013), published their findings in Nature Genetics.

The study involved more than 70,000 men and women of African ancestry, making it one of the largest genome-wide association studies. Within this population, researchers were able to identify three new common genetic variants, known as single nucleotide polymorphisms (SNPs), which are associated with body mass index (BMI) and obesity in the sample population. Also of significance, the study showed these genetic variants appear to affect BMI in the U.S. population among those with no known African ancestry. In addition, nearly all genetic variants previously identified as being linked to obesity in populations of European descent also were shown to influence BMI in this sample of African descent.

"A person who carries these variants may be predisposed to having higher BMI or becoming obese, but it is important to note these genes only account for a small percentage of higher BMI in the population," Taylor said. "We know environmental and behavioral factors like poor diet and lack of physical activity are the main reasons for obesity.

"Our discovery provides evidence that genes can influence obesity; it paves the way for examining rare genetic variants that are thought to be influential in common diseases such as obesity and cardiovascular disease."

Rare genetic variants can be identified through genome-wide DNA sequencing, a technique only recently becoming cost-effective and feasible for most researchers, she said.

In the future, this type of biological information could help predict who is at higher risk for obesity, therefore helping individuals become more aware of their need for prevention through diet and lifestyle choices. Personalized treatment through medication to reduce obesity could be another part of the equation.


'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. Will a genetic mutation cause trouble? Ask Spliceman
3. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
4. Perception and preference may have genetic link to obesity
5. A foot in the door to genetic information
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Epigenetics and epidemiology -- hip, hype and science
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. First complete full genetic map of promising energy crop
11. Genetic research develops tools for studying diseases, improving regenerative treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/15/2016)... , April 15, 2016 ... "Global Gait Biometrics Market 2016-2020,"  report to their ... ) , ,The global gait biometrics market ... 13.98% during the period 2016-2020. Gait ... which can be used to compute factors that ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... Parallel 6 ... trials, announced today the Clinical Reach Virtual Patient Encounter CONSULT module which ... with the physician and clinical trial team. , Using the CONSULT module, patients and ...
(Date:6/27/2016)... Ginkgo Bioworks , a leading organism design company ... as one of the World Economic Forum,s Technology ... companies. Ginkgo Bioworks is engineering biology to manufacture ... the nutrition, health and consumer goods sectors. The ... Fortune 500 companies to design microbes for their ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
Breaking Biology Technology: