Navigation Links
Genetic discovery found to influence obesity in people of African ancestry
Date:4/15/2013

LOUISVILLE, Ky. The largest genetic search for "obesity genes" in people of African ancestry has led to the discovery of three new regions of the human genome that influence obesity in these populations and others.

University of Louisville School of Public Health and Information Sciences Department of Epidemiology and Population Health researcher Kira Taylor, PhD, and her team today (April 14, 2013), published their findings in Nature Genetics.

The study involved more than 70,000 men and women of African ancestry, making it one of the largest genome-wide association studies. Within this population, researchers were able to identify three new common genetic variants, known as single nucleotide polymorphisms (SNPs), which are associated with body mass index (BMI) and obesity in the sample population. Also of significance, the study showed these genetic variants appear to affect BMI in the U.S. population among those with no known African ancestry. In addition, nearly all genetic variants previously identified as being linked to obesity in populations of European descent also were shown to influence BMI in this sample of African descent.

"A person who carries these variants may be predisposed to having higher BMI or becoming obese, but it is important to note these genes only account for a small percentage of higher BMI in the population," Taylor said. "We know environmental and behavioral factors like poor diet and lack of physical activity are the main reasons for obesity.

"Our discovery provides evidence that genes can influence obesity; it paves the way for examining rare genetic variants that are thought to be influential in common diseases such as obesity and cardiovascular disease."

Rare genetic variants can be identified through genome-wide DNA sequencing, a technique only recently becoming cost-effective and feasible for most researchers, she said.

In the future, this type of biological information could help predict who is at higher risk for obesity, therefore helping individuals become more aware of their need for prevention through diet and lifestyle choices. Personalized treatment through medication to reduce obesity could be another part of the equation.


'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Related biology news :

1. Nearby chimpanzee populations show much greater genetic diversity than distant human populations
2. Will a genetic mutation cause trouble? Ask Spliceman
3. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
4. Perception and preference may have genetic link to obesity
5. A foot in the door to genetic information
6. Genetic survey of endangered Antarctic blue whales shows surprising diversity
7. Epigenetic signatures direct the repair potential of reprogrammed cells
8. Epigenetics and epidemiology -- hip, hype and science
9. Genetic variation in East Asians found to explain resistance to cancer drugs
10. First complete full genetic map of promising energy crop
11. Genetic research develops tools for studying diseases, improving regenerative treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... and BANGALORE, India , April ... EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... today announced a global partnership that will provide ... to use mobile banking and payment services.      ... a key innovation area for financial services, but it also ...
(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
Breaking Biology News(10 mins):
(Date:5/25/2016)... Diego, Calif. (PRWEB) , ... May 25, 2016 , ... ... Diego area and has consistently been rated one of its top attractions. Fortune ... the globe to participate in a unique and intimate team-building experience. , Each event ...
(Date:5/25/2016)... (PRWEB) , ... May 25, 2016 , ... ... Michael Fitzmaurice recently became double board-certified in surgery and surgery of the hand ... Dr. Fitzmaurice is no stranger to going above and beyond in his pursuit ...
(Date:5/25/2016)... LAKE CITY, UTAH. (PRWEB) , ... May 25, 2016 , ... ... efficiencies in healthcare information exchange, today announced that Charles W. Stellar has been named ... as WEDI’s interim CEO since January 2016. As an executive leader with more than ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... attacks, diabetes, and traumatic injuries, will be accelerated by research at Worcester Polytechnic ... into engines of wound healing and tissue regeneration. , The novel method, developed ...
Breaking Biology Technology: