Navigation Links
Genetic 'conductor' involved with new brain cell production in adults
Date:6/29/2011

A team of North Carolina State University researchers has discovered more about how a gene connected to the production of new brain cells in adults does its job. Their findings could pave the way to new therapies for brain injury or disease.

Most areas of the brain do not generate new brain cells, or neurons, after we are born. One exception is the olfactory bulb, the brain's scent processor, which continually produces new neurons. Dr. Troy Ghashghaei, assistant professor of neurobiology, had previously found a gene known as Foxj1connected to the production of an area inside the olfactory bulb where stem cells could form. Ghashghaei and his team discovered that Foxj1 was an "off switch" that told neuronal stem cells to stop reproducing and triggered the development of a stem cell "niche" in the olfactory bulbs.

However, further experiments with newly developed genetically modified mice unexpectedly revealed that a fraction of Foxj1-expressing cells actually functioned as stem cells. But they only did so until the mouse reached the age equivalent of a human toddler, not throughout adulthood. In addition, the number of neurons generated by these cells was much lower than expected, which led to more questions about its function.

"Essentially, the experiments we did weren't giving us the numbers of neurons from Foxj1-expressing stem cells that we expected. We could have gotten disappointed with what may have been perceived as a road-block in our findings" says Ghashghaei. "If the gene was one that stem cells had to express in order to produce neurons, then we should have seen a greater number of neurons produced from the Foxj1-expressing stem cells. Instead, only about three percent of the olfactory neurons came from the Foxj1 stem cells. More importantly, we could not identify these unique neurons as belonging to known types of neurons in the olfactory system."

These findings and subsequent experimentation helped the team disc
'/>"/>

Contact: Tracey Peake
tracey_peake@ncsu.edu
919-515-6142
North Carolina State University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genetic testing for inherited cardiac conditions is patchy in Europe
2. Genome editing, a next step in genetic therapy, corrects hemophilia in animals
3. New curation tool a boon for genetic biologists
4. First genetic mutation linked to heart failure in pregnant women
5. Family genetic research reveals the speed of human mutation
6. Researchers improve method for finding genetic mistakes that fuel cancer
7. Penn researchers show new evidence of genetic arms race against malaria
8. Genetics of melanoma chemoresistance
9. USC researchers discover genetic mutation causing excessive hair growth
10. DTC genetic tests neither accurate in their predictions nor beneficial to individuals
11. The importance of inner values -- female sparrows test the genetic make-up of their mates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2014)... Aug. 19, 2014 To improve students, chances ... grades, the University of Houston (UH) implemented a ... students at risk for failure. , Through ... Board (THECB), the Department of Biology and Biochemistry ... students taking "General Biology" for non-majors and "Introductory ...
(Date:8/19/2014)... It,s not a monkey. It,s not a lemur. It,s not ... the Philippine tarsier: a tiny, adorable and downright "cool" primate ... that Americans are familiar with," said Rafe Brown, curator-in-charge at ... eyes and ears; an extremely cute, furry body; a long ... expanded fingers and toe tips that look a bit like ...
(Date:8/19/2014)... biomarker strongly associated with basal-like breast cancer, a ... types of chemotherapy. The biomarker, a protein called ... designed to treat this often deadly cancer. , ... Cancer Genome Atlas, molecular biologists Curt M. Horvath ... bioinformatics techniques to detect patterns of gene expression ...
Breaking Biology News(10 mins):University of Houson program earns kudos for improving grades, retaining students 2University of Houson program earns kudos for improving grades, retaining students 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3Biomarker in an aggressive breast cancer is identified 2Biomarker in an aggressive breast cancer is identified 3
... Some soil microorganisms are capable of forging associations with ... these relationships play a highly important ecological and agronomic ... a fungus) thus gives plants a mechanism for improving ... has been in existence for 400 million years and ...
... Oregon State University graduate student working on a ... station on the Tahoe National Forest has photographed ... been confirmed in California since the 1920s. Katie ... on another carnivore called the American marten when ...
... defined biochemical pathway in plants may provide the scientific ... of alternative transportation fuels than currently can be produced, ... materials that determine cell shape and size through a ... geneticist and cellular biologist. By learning more about the ...
Cached Biology News:A common genetic mechanism discovered in nitrogen-fixing plants 2A common genetic mechanism discovered in nitrogen-fixing plants 3Scientists believe photograph depicts wolverine in California 2Newly defined signaling pathway could mean better biofuel sources 2Newly defined signaling pathway could mean better biofuel sources 3Newly defined signaling pathway could mean better biofuel sources 4
(Date:8/20/2014)... Not long ago, it was more or ... late in the development cycle – even after the ... suggest that, like many things GxP, expectations for early ... multiple drug sponsors have been required by authorities to ... phase I/II. It’s not only clinical trial material containers ...
(Date:8/20/2014)... improve the health of your heart, researchers have discovered. ... a standard TENS machine like those designed to relieve ... the small raised flap at the front of the ... The stimulation changed the influence of the nervous system ... can drive failing hearts too hard. , Professor Jim ...
(Date:8/20/2014)... 20, 2014 GraphDB™ 6.0 ... including improvements to the enterprise replication cluster, faster ... Lucene, SOLR and Elasticsearch. This release happens to ... performance triplestore – GraphDB™ was formerly known as ... the only mature enterprise resilient RDF triplestore will ...
(Date:8/19/2014)... 19, 2014 Shimadzu Scientific Instruments ... Prominence-i and Nexera-i, adding to the company’s extensive ... functionality, an intuitive operating environment, and full automation, ... efficient workflow for conventional to ultra-high-speed analysis. ... and intelligent design so users can begin building ...
Breaking Biology Technology:Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2'Tickling' your ear could be good for your heart 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3
... reflection, and this one is no different. These last 12 months ... doubt look back on 2005 and pronounce it the year the ... of things, the previous four years were a standing eight count, ... like hell and a lot was lost on bad bets, but ...
... newsletter contains the most-read stories from our Web site in 2005. ... month to over 70,000 last month, many of them sticking around ... to what drew your interest. , ,Let me take a moment ... isnt until March 2 and were more than a third full ...
... care in the United States are enough to make anyone ... seven Americans (15.7 percent) lack health insurance. Thats just short ... federal figures, health spending accounts for 15.3 percent of the ... works out to $5,670 for each American. By 2013, the ...
Cached Biology Technology:2005: the year of the comeback 22005: the year of the comeback 3Health care economics make definition of 'cost' problems difficult 2Health care economics make definition of 'cost' problems difficult 3
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
... by N.C. Price (1996) • ... on protein chemistry and the ... proteins. Data on the following ... size determination, amino acid analysis ...
Edited by D.M. Gersten (1996) Provides comprehensive descriptions of the techniques available for analytical gel electrophoresis of proteins and offers clear step-by-step protocols for all of the m...
...
Biology Products: