Navigation Links
Genetic changes behind sweet tooth
Date:4/4/2011

The substance ghrelin plays an important role in various addictions, such as alcoholism and binge-eating. It also impacts on sugar consumption, which is due, in part, to genetic factors, reveals new research from the University of Gothenburg, Sweden.

Ghrelin is a neuropeptide that both activates the brain's reward system and increases appetite. This means that when we are hungry, levels of ghrelin increase, activating the brain's reward system, and this, in turn, increases our motivation to look for food. Previous research from the Sahlgrenska Academy has linked ghrelin to the development of various dependencies, such as drug addiction and alcoholism.

In a new study published in the online version of the journal Plos One, researchers examined the genes of 579 individuals chosen from the general public. It emerged that people with certain changes in the ghrelin gene consume more sugar than their peers who do not have these changes. This link was also seen in people who consumed large amounts of both sugar and alcohol.

Trials have also been carried out using rats, where the researchers found that when ghrelin was blocked the rats reduced their consumption of sugar and were less motivated to hunt for sugar.

"This shows that ghrelin is a strong driver when it comes to tracking down rewarding substances such as sugar or alcohol," says researcher Elisabet Jerlhag from the Sahlgrenska Academy's Department of Pharmacology.

These results go hand in hand with the researchers' previous findings which showed that substances that block the ghrelin system reduce the positive effects of addictive drugs and that changes in the ghrelin gene are associated with high alcohol consumption, weight gain in alcoholics and smoking.

The researchers are now a step closer to understanding what happens in the brain and the body in different types of addictive behavior. Understanding these mechanisms means that new drugs can be developed to block the ghrelin system and used to treat patients who are addicted to alcohol or who suffer from binge-eating disorders.

"This knowledge could also make it easier for society to view dependency as an illness and could mean that these people can get the treatment they need more readily," says Jerlhag.


'/>"/>

Contact: Elisabet Jerlhag
elisabet.jerlhag@pharm.gu.se
46-031-786-3418
University of Gothenburg
Source:Eurekalert

Related biology news :

1. Anna-Kaisa Niemi awarded 2011 Genzyme/ American College of Medical Genetics Foundation Fellowship
2. Zimmerman receives Richard King Trainee Award for best publication in genetics in medicine
3. Do you own your genetic identity?
4. An ancestral link between genetic and environmental sex determination
5. UC Riverside geneticists to study how plants adapt to a changing environment
6. MARC Travel Awards announced for GSA 26th Fungal Genetics Meeting
7. New data published in Nature Genetics demonstrate that tiny LNA-based compounds developed by Santaris Pharma A/S inhibit entire disease-associated microRNA families
8. Vanderbilt-Ingram Cancer Center launches online genetic research tool
9. Genetic analysis reveals history, evolution of an ancient delicacy -- morels
10. New advances in genetic studies of Fanconi anemia patients
11. For first time, scientists show an HIV vaccine impacts the genetic makeup of the virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2016)... , March 23, 2016 ... Interesse erhöhter Sicherheit Gesichts- und Stimmerkennung mit ... Inc. (NASDAQ: MESG ), ein ... dass das Unternehmen mit SpeechPro zusammenarbeitet, um ... der Finanzdienstleistungsbranche, wird die Möglichkeit angeboten, im ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... (NSO), which operates the highest sample volume laboratory in ... Tute Genomics and UNIConnect, leaders in clinical sequencing informatics ... the launch of a project to establish the informatics ... NSO has been contracted by the ...
(Date:3/18/2016)... , March 18, 2016 ... Suppliers of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure ... & security companies in the border security market and the ... and Europe has led visiongain ... companies improved success. --> defence & security ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a ... discoveries to the medical community, has closed its Series ... Matthew Nunez . "We have received a ... the capital we need to meet our current goals," ... provide us the runway to complete validation on the ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® Inc. (RCA), ... free webinar on Performing Quality Investigations: Getting to Root Cause. ... no charge. , Incomplete investigations are still a major concern to the Regulatory ...
(Date:6/22/2016)... June 22, 2016 Cell Applications, Inc. ... them to produce up to one billion human ... within one week. These high-quality, consistent stem cells ... cells and spend more time doing meaningful, relevant ... proprietary, high-volume manufacturing process that produces affordable, reliable ...
Breaking Biology Technology: