Navigation Links
Genetic cause of innate resistance to HIV/AIDS
Date:7/16/2008

This press release is available in French.

Montreal, 16 July 2008 - Some people may be naturally resistant to infection with HIV, the virus that causes AIDS. The results of a study conducted by Dr. Nicole Bernard of the Research Institute of the McGill University Health Centre (MUHC) bring us closer to a genetic explanation. Her study findings were published on July 16 in the journal AIDS.

The simultaneous expression of certain versions of two specific genes called KIR3DL1 and HLA-B*57 is thought to be at the root of some cases of this innate resistance to HIV infection. Depending on which versions of these two genes the patient has, he or she will resist HIV infection or develop AIDS at a slower rate.

These results were obtained by comparing the genetic profiles of people undergoing primary HIV infection ( in their first year of infection) to those repeatedly exposed to HIV but non-infected. The group of exposed but non-infected patients came from a cohort studied by Dr. Julie Bruneau of the Centre hospitalier de l'Universit de Montral. The cohort of primary HIV infected patients is studied by Dr. Jean-Pierre Routy, from the MUHC. Analyses show that the "good" versions of both genes were present in 12.2% of exposed but non-infected subjects versus only 2.7% in patients in primary HIV infection.

As of yet, no study has clearly described the mechanism of this protection. The KIR3DL1 gene codes for a receptor on the surface of the immune system's natural killer (NK) cells, which when activated destroy infected cells in the body. The HLA-B*57 gene codes for a protein normally found on the surface of all body cells that binds the KIR3DL1 and dampens NK cell activity. The most likely hypothesis is that HIV prevents the HLA-B*57-encoded protein from being expressed on the surface of the infected cells, making it unavailable to bind KIR
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related biology news :

1. Statin does not appear helpful for children with learning disabilities caused by genetic disorder
2. The epigenetics of increasing weight through the generations
3. Sociological research shows combined impact of genetics, social factors on delinquency
4. Zooming in on genetic shuffling
5. Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery
6. HapMap browsing and DDDP methods for genetic analysis featured in CSH Protocols
7. Political participation is partially rooted in genetic inheritance
8. International team identifies 21 new genetic risk factors for Crohns disease
9. Why do people vote? Genetic variation in political participation
10. Automated microfluidic device reduces time to screen small organisms for genetic studies
11. Drug reverses mental retardation caused by genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... expression is the process whereby the genetic information ... such as proteins, which have numerous different functions ... an important intermediary during gene expression, by relating ... mechanisms involved in manufacturing proteins. , By ... molecules present in an organism at a given ...
(Date:4/17/2014)... and plant life, but there,s an invisible machine underground. ... soil, decomposing organic matter and releasing carbon into the ... in ecological systems, their identities have only now been ... genetic map of more than 10,000 species of fungi ... in the Proceedings of the National Academy of ...
(Date:4/17/2014)... International researchers, led by the Australian National University ... sea-level changes and deep-sea temperature variability over the ... scientists better understand the climate surrounding ice ages ... help determine the relationship between carbon dioxide levels, ... ANU, the University of Southampton (UoS) and the ...
Breaking Biology News(10 mins):Rapid and accurate mRNA detection in plant tissues 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3Ancient sea-levels give new clues on ice ages 2
... used to identify each stage of skin cancer tumor ... Melanomas grow in two phases: radial and vertical. Vertical-phase ... other parts of the body) than radial melanomas. , ... into radial and vertical portions, and through microarray techniques ...
... researchers and conducted by the North Central Cancer Treatment Group ... incurable form of recurrent brain cancer slowed tumor growth in ... it. The same research team also developed a screening technique ... treatment. , Mayo researchers will present these findings at the ...
... the United States and elsewhere has successfully completed a ... rare Roberts syndrome, whose physical manifestations often include cleft ... of babies whose mothers took thalidomide during pregnancy. , ... advance online section of Nature Genetics, proves that genes ...
Cached Biology News:'Smart drug' targets deadly brain cancer 2'Smart drug' targets deadly brain cancer 315-year hunt finds cause of pseudothalidomide syndrome 215-year hunt finds cause of pseudothalidomide syndrome 315-year hunt finds cause of pseudothalidomide syndrome 4
(Date:1/15/2014)... (PRWEB) January 15, 2014 AudioNotch is ... new therapy for the treatment of tinnitus. Patients listen ... frequency, and over a period of weeks to months, their ... Therapy in two forms: Notched Music and Notched White Noise. ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Histogen, Inc., ... products of cells grown under simulated embryonic conditions, today ... agreement with Suneva Medical, Inc. for physician-dispensed aesthetic products ... , This agreement is an amendment to the ...
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s ... better care of my furry companion." Nowadays there are pet salons, ... cases to take the little canine or feline darlings along wherever ... buy some pricey toys at the pet store. But anyone who ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2
... - Human Tests of Nasal Powder Vaccine with Bird Flu ... - Preservative Free ... - Room Temperature More Than 30 Months ... - ...
... Nabi,Biopharmaceuticals (Nasdaq: NABI ) today announced that Dr. ... in the,Thomas Weisel Partners Healthcare Conference, to be held ... Dr. Hudson,s presentation at the,conference is scheduled for Thursday, ... scheduled to participate in the Bear Stearns Healthcare Conference,to ...
... GAITHERSBURG, Md., Aug. 23 MedImmune, Inc. announced,today ... intellectual,property to Novartis to support the development and ... seasonal, pre-pandemic and,pandemic influenza vaccines. Reverse genetics is ... be generated from segments of DNA. For prospective,pandemic ...
Cached Biology Technology:Carrington Completes $8 Million Financing 2Carrington Completes $8 Million Financing 3Nabi Biopharmaceuticals to Present at Upcoming Industry Conferences 2MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production 2
... is a highly advanced digital imaging ... imaging and automation technology that is ... archving/retrieval and colored professional reporting. The ... fastest scanning and detection modules for ...
... HV high-voltage power supply, with temperature probe, 100-120 ... 5,000 V, 500 mA, and 400 W. The ... between 0 and 90 degrees C during electrophoresis. ... Power cord and instructions are provided. Dimensions are ...
... Model 111 mini IEF cell is an ... (IEF) using polyacrylamide or agarose slab gels. ... lid, graphite electrodes, casting tray, 5 glass ... for polyacrylamide, 5 sample templates, and instructions. ...
... The Biomek FX provides complete ... applications. With 96-, 384-, ... heads in either single or ... FX offers maximum speed and ...
Biology Products: