Navigation Links
Genetic cause of innate resistance to HIV/AIDS
Date:7/16/2008

This press release is available in French.

Montreal, 16 July 2008 - Some people may be naturally resistant to infection with HIV, the virus that causes AIDS. The results of a study conducted by Dr. Nicole Bernard of the Research Institute of the McGill University Health Centre (MUHC) bring us closer to a genetic explanation. Her study findings were published on July 16 in the journal AIDS.

The simultaneous expression of certain versions of two specific genes called KIR3DL1 and HLA-B*57 is thought to be at the root of some cases of this innate resistance to HIV infection. Depending on which versions of these two genes the patient has, he or she will resist HIV infection or develop AIDS at a slower rate.

These results were obtained by comparing the genetic profiles of people undergoing primary HIV infection ( in their first year of infection) to those repeatedly exposed to HIV but non-infected. The group of exposed but non-infected patients came from a cohort studied by Dr. Julie Bruneau of the Centre hospitalier de l'Universit de Montral. The cohort of primary HIV infected patients is studied by Dr. Jean-Pierre Routy, from the MUHC. Analyses show that the "good" versions of both genes were present in 12.2% of exposed but non-infected subjects versus only 2.7% in patients in primary HIV infection.

As of yet, no study has clearly described the mechanism of this protection. The KIR3DL1 gene codes for a receptor on the surface of the immune system's natural killer (NK) cells, which when activated destroy infected cells in the body. The HLA-B*57 gene codes for a protein normally found on the surface of all body cells that binds the KIR3DL1 and dampens NK cell activity. The most likely hypothesis is that HIV prevents the HLA-B*57-encoded protein from being expressed on the surface of the infected cells, making it unavailable to bind KIR
'/>"/>

Contact: Isabelle Kling
isabelle.kling@muhc.mcgill.ca
514-843-1560
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related biology news :

1. Statin does not appear helpful for children with learning disabilities caused by genetic disorder
2. The epigenetics of increasing weight through the generations
3. Sociological research shows combined impact of genetics, social factors on delinquency
4. Zooming in on genetic shuffling
5. Genetic Engineering & Biotechnology News reports on novel hit-to-lead drug discovery
6. HapMap browsing and DDDP methods for genetic analysis featured in CSH Protocols
7. Political participation is partially rooted in genetic inheritance
8. International team identifies 21 new genetic risk factors for Crohns disease
9. Why do people vote? Genetic variation in political participation
10. Automated microfluidic device reduces time to screen small organisms for genetic studies
11. Drug reverses mental retardation caused by genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... Listeria is a dreaded bacterium that can be ... last few weeks, 28 persons in Denmark have been ... in supermarkets. 13 have died. , The bacterium is ... uncanny ability to adapt to changes in its surroundings, ... Together with colleagues from the Department of Biochemistry and ...
(Date:8/26/2014)... have provided the first evidence that the lack ... early signs of dementia. , Published in ... absence of the protein MK2/3 promotes structural and ... These changes were shown to have a significant ... learning and memory formation capabilities. , An absence ...
(Date:8/26/2014)... Casey Diekman, assistant professor of mathematical sciences at New ... greater insight into the biological clock that sets the ... behavior of humans and all other mammals with fundamental ... and dark experienced each day and with seasonal change. ... natural patterns of sleep/wake behavior which, when disrupted by ...
Breaking Biology News(10 mins):Researchers discover why Listeria bacterium is so hard to fight 2Researchers discover why Listeria bacterium is so hard to fight 3Lack of naturally occuring protein linked to dementia 2Researching fundamental rhythms of life 2Researching fundamental rhythms of life 3
... CHURCH, Va., Feb. 2 CSC (NYSE: ... 12 contractors awarded a Biometrics Operations and Support Services ... Biometrics Task Force (BTF). The indefinite-delivery/indefinite-quantity (IDIQ) contract covers ... to meet the mission needs of BTF business and ...
... 25 percent of eligible African-American adolescents have received the ... Association for Cancer Research conference on the Science of ... of the treatment and might respond to more education. ... funding research to develop ways to increase the rate ...
... University is tracking the movement of the Redbay Ambrosia beetle, ... may severely affect the production of avocados, a $15 million ... in the United States near Savannah, Ga., in 2002, the ... causing widespread mortality in Redbay trees. Dr. Frank Koch, a ...
Cached Biology News:CSC Awarded Department of Defense Biometrics Contract 2African-Americans aware and accepting, but often do not receive, the HPV vaccine 2Holy guacamole: invasive beetle threatens Florida's avocados 2
(Date:8/27/2014)... , Aug. 27, 2014  A novel ... to help physicians better identify early-stage disease, when ... disability, according to a new study in The ... Diagnostics (NYSE: DGX ) and other ... 14-3-3eta protein outperformed conventional antibody-serum testing, including rheumatoid ...
(Date:8/27/2014)... “We are honored to be named to this ... of Radiant Sage. “We are offering truly ground-breaking clinical ... market to a different level. We are enabling ... and effectively manage the massive amounts of medical imaging ... read by trained physicians. Being recognized by technology industry ...
(Date:8/27/2014)... , Aug. 27, 2014 Guggenheim Securities, the ... today announced the hiring of veteran equity analyst Charles ... analyst. Mr. Butler will focus on the biotech/biopharma sector. ... a wealth of experience and a broad network of ... Senior Managing Director and Head of Equities at Guggenheim ...
(Date:8/27/2014)... LONDON , Aug. 27, 2014 ... The Graphene Opportunity - A Rational ... Is Graphene The New Nanotech? A similar ... predictions of applications ranging from microelectronics to water ... today announced the availability of the Graphene Opportunity ...
Breaking Biology Technology:Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Radiant Sage Named to CIOReview List of 100 Most Promising Technology Companies 2Guggenheim Securities Hires Analyst Charles "Tony" Butler to Expand Healthcare Coverage 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... Group (NYSE: SCR ), a leading manufacturer ... pharmaceuticals,in the rapidly growing China market, announced today ... results on Tuesday, August 5, 2008, before,the market ... officer,Jinsheng Ren, and chief financial officer, Frank Zhigang ...
... ... Achieve Benefits of H.R. 6331, GREAT RIVER, N.Y., July ... and services for health and,human services organizations, today announced dates ... electronic,prescribing and the new Medicare bill passed by the U.S. ...
... Inc.,( http://www.nikoninstruments.com/ ) announced its new SMZ-445/460,stereoscopic zoom ... at a low cost for the Industrial and ... range of applications, from routine,quality control to semiconductor ... to 3.5x zoom magnification, and SMZ-460, 0.7x to,3.0x ...
Cached Biology Technology:Simcere Pharmaceutical Group to Announce Second Quarter 2008 Earnings on Tuesday, August 5, 2008 2Simcere Pharmaceutical Group to Announce Second Quarter 2008 Earnings on Tuesday, August 5, 2008 3Netsmart Technologies Web Seminar Helps Behavioral Health Organizations Understand Electronic Prescribing and the Importance of New Medicare-Related E-Prescribing Legislation 2Netsmart Technologies Web Seminar Helps Behavioral Health Organizations Understand Electronic Prescribing and the Importance of New Medicare-Related E-Prescribing Legislation 3Nikon Instruments Introduces New Microscopes and Illumination Stand for Education and OEM Markets 2
...
MSE ANTI CAN. CD3:FITC/RAT ANTI CD4:RPE...
Antibodies were affinity purified using epitopes specific to JLP immobilized on solid support....
This issue concentrated on the purification of proteins for specific purposes (i.e. large-scale purification, purification for therapeutic use, etc.)...
Biology Products: