Navigation Links
Genetic breakthrough offers promise in tackling kidney tumors
Date:1/10/2008

A new study has shown promising results in fighting a severe genetic disorder which can create tumours throughout the body.

Advances in genetic knowledge have transformed our understanding of disease in recent years. We now know which genes are linked to a wide variety of conditions. However, so far, very few cures and treatments have developed as a result of this knowledge.

Now a UK study led by researchers at Cardiff University suggests that a chemical first found on Easter Island could treat the genetic disorder tuberous sclerosis.

Tuberous sclerosis is an inherited disease affecting children and adults which causes tumours to grow in many of the organs of the body. Its consequences can include autism and epilepsy through its effects on the brain. A team from the Institute of Medical Genetics at Cardiff Universitys School of Medicine was the first to identify the genes linked with the disease TSC1 and TSC2.

The Institute is now leading a UK-wide study on a new treatment involving the drug Sirolimus. This was first identified from a soil sample taken from Easter Island and has been shown in the past to control the activity of a protein, mTOR, which is normally controlled by the TSC1 and TSC2 genes. If the genes fail, mTOR is too active leading to tuberous sclerosis.

The UK study tested the effects of Sirolimus on kidney tumours in patients with tuberous sclerosis and a related condition, LAM, a lung and kidney disease affecting young women. The study is at the half-way stage but after one year of treatment the diameters of the tumours have shrunk by an average of 26 per cent. A parallel study in the United States has also reported similar results.

Professor Julian Sampson, director of the Institute of Medical Genetics, said: This is a small-scale study and we will be treating patients for a further year before it is completed. However, what we have seen so far is very promising and already justifies progression to a larger study in many more patients. The findings offer new hope for what is a very serious and distressing genetic disease.


'/>"/>

Contact: Stephen Rouse
stephenrouse@hotmail.co.uk
44-292-087-5596
Cardiff University
Source:Eurekalert

Related biology news :

1. Genetic variant predicts antipsychotic response for schizophrenia patients by ethnicity
2. Recurrent genetic deletion linked to autism
3. Study examines genetic defects linked to body abnormalities in patients with childhood cancer
4. New clinical trial results show how personalized medicine will alter treatment of genetic disorders
5. Cognitive, genetic clues identified in imaging study of alcohol addiction
6. Plant geneticists find veritas in vino
7. UT-Houstons Northrup and colleagues uncover genetic link to spina bifida
8. Study of bear hair will reveal genetic diversity of Yellowstones grizzlies
9. A research of the UGR shows the genetic predisposition to develop alcohol abuse
10. USC researchers explore genetic causes for male infertility
11. Study finds first-ever genetic animal model of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2017)... Florida , April 17, 2017 NXT-ID, ... technology company, announces the filing of its 2016 Annual Report on ... and Exchange Commission. ... on Form 10-K is available in the Investor Relations section of ... as on the SEC,s website at http://www.sec.gov . ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... ... specialists DST Diagnostische Systeme & Technologien GmbH, thereby expanding its product portfolio to ... from hay fever, urticaria, asthma, atopic eczema or a food allergy. Allergies are ...
(Date:6/22/2017)... ... June 22, 2017 , ... The first human cell line HeLa, established ... first data on cross-contamination of human cell lines with HeLa cells were published. Until ... cell culture labs and is associated with dramatic consequences for research. , In ...
(Date:6/20/2017)... (PRWEB) , ... June 20, 2017 , ... Biologist Dawn ... men. While researching her latest book, Men Chase, Women Choose: The Neuroscience of Meeting, ... love has a physiological effect on men. ”The logical next step, in my estimation, ...
(Date:6/20/2017)... NJ (PRWEB) , ... June 20, 2017 , ... Do ... makes the transition from being a trusted supplier in the weighing industry, to extending ... cell extractions, ELISA essays, enzyme reactions, immunoassays, hybridizations and more, allowing for its ...
Breaking Biology Technology: