Navigation Links
Genetic breakthrough explains dangerously high blood glucose levels
Date:5/1/2008

This release is available in French.

Canadian, French and British researchers have identified a DNA sequence that controls the variability of blood glucose levels in people. This is a potentially significant discovery because high blood glucose levels in otherwise healthy people often are indications of heart disease and higher mortality rates. The results will be published May 1 in the online version of the journal Science.

The research was conducted by Dr. Phillippe Froguel and colleagues at Imperial College London and le Centre national de la recherche scientifique (CNRS) in Lille, France, in collaboration with Dr. Robert Sladek, Dr. Constantin Polychronakos and their teams at McGill University and the McGill University Health Centre (MUHC) in Montreal. Dr. Ghislain Rocheleau, a post-doctoral fellow in Dr. Sladeks lab, is the studys co-first author. The scientists worked with data collected from a large genome study originally conducted for diabetes research that looked at over 390,000 different locations or loci on the human genome. The studys first important diabetes results were published in 2007 and received worldwide media attention.

In this study, researchers looked at the genetic code of healthy, non-diabetic individuals whose blood glucose levels were in the normal range. They discovered that a single DNA mutation within three different genes explained, in part, why some individuals have high or low blood glucose levels. The researchers believe that these genes actually affect the threshold level of glucose in the bloodstream, which triggers the secretion of insulin. The higher the threshold, the higher the blood glucose level will rise before insulin starts to regulate it.

These sequences explain about 5 per cent of the normal variation in blood glucose levels between otherwise healthy people, explained Dr. Sladek, o
'/>"/>

Contact: Mark Shainblum
mark.shainblum@mcgill.ca
514-398-2189
McGill University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Epigenetic research uncovers new targets for modification enzymes
2. Mapping the genetic locus for triglycerides
3. Genetic sequencing of protein from T. rex bone confirms dinosaurs link to birds
4. American College of Medical Genetics makes genetic testing recommendations in new policy statement
5. Scientists clarify a mechanism of epigenetic inheritance
6. Genetic variant mimics effect of heart failure medications
7. Researchers discover critical detail of cellular defense against genetic mistakes
8. Concentrating on different aspects of pain leads to breakthrough in migraine genetics
9. Genetic Engineering & Biotechnology News reports on growing use of cell-based assays
10. Largest ever study of genetics of common disease just got bigger
11. A genetic cause for iron deficiency
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ) ... Sensors Market Forecast and Opportunities 2020" report ... is projected to grow at a CAGR over ... industrial and healthcare sectors are the key application ... adoption of MEMS technology in sensors is growing ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report to ... for Iris Biometrics in US$ Thousands. The report provides separate ... Japan , Europe , ... , and Latin America . ...
(Date:3/17/2015)... , March 17, 2015 MedNet ... specializing in clinical study management systems, is pleased ... attendance at ARENA,s Outsourcing in Clinical Trials Southeast ... event provides an excellent forum for MedNet to ... and affordable software-as-a-service (SaaS) eClinical technology platform. ...
Breaking Biology News(10 mins):India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2
... the University of Michigan,s School of Natural Resources and ... disparities in access to healthy food across the state. ... in 18 small to mid-sized cities to better understand ... defines easy access to safe and healthy food. ...
... led by researchers from the University of York suggests ... such as the iconic Acacia tree., Acacia, the thorny ... important component of ecosystem diversity. However, the researchers found ... protection through the protected area network, which includes national ...
... This press release is available in German . ... laboratory at Bielefeld University,s Center for Biotechnology (CeBiTec) have ... ,international Genetically Engineered Machine competition, (iGEM) at the Massachusetts ... The goal of their project was to develop a ...
Cached Biology News:U-M researchers to study 'food security' across Michigan 2Protected areas in East Africa may not be conserving iconic plants 2Protected areas in East Africa may not be conserving iconic plants 3Synthetic biofilter wins through to the top 'Sweet 16' in Boston 2
(Date:4/17/2015)... Horsham, PA (PRWEB) April 17, 2015 ... Tech), a leader in regulatory data management, preparation, and ... announced today the availability of a new Lot Distribution ... that are required to remain compliant with the FDA’s ... Used by the FDA to monitor the volume and ...
(Date:4/17/2015)... , April 17, 2015 /PRNewswire/ - SQI Diagnostics ... and diagnostics company that develops and commercializes proprietary ... today announced that it has received approval from ... of 5,126,044 outstanding common share purchase warrants ("the ... connection with the Company,s May 2013 private placement ...
(Date:4/17/2015)...  US-Australian drug discovery company, Novogen, today announced ... with the Feinstein Institute for Medical Research (,Feinstein ... to collaborate with the objective of developing effective ... brings together the drug discovery expertise of Novogen ... Feinstein Institute in neurosciences and oncology. ...
(Date:4/17/2015)... Houston, TX (PRWEB) April 17, 2015 ... genomics and proteomics technologies, announced today that it ... sequencing system, an innovative multiplex PCR based targeted ... ultra-high resolution sequence analysis, that enables accurate detection ... pending Relay-PCR™ and Omega-Primer™ technologies. The company will ...
Breaking Biology Technology:Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 2Reed Tech Announces FDA Lot Distribution Report (LDR) Service for Manufacturers of Biologic Products 3SQI Diagnostics to Extend Warrant Expiry 2SQI Diagnostics to Extend Warrant Expiry 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 2LC Sciences Seeks Beta Testers of Targeted Sequencing Method Ahead of Q4 Launch 3
... its revolutionary Trusted LASIK Surgeons directory service and website ... resource for consumers seeking to improve their vision. What ... unique screening process ensuring that only those who are ... eye surgery in the United States are listed. Refractive ...
... Sciences Discovery,Fund (LSDF) has awarded nearly $4.7 million to ... and to support initial research into,three new vaccines for ... funded by Washington,s$350 million tobacco-lawsuit-settlement bonus,and provides essential funding ... WAVA core operations during ...
... Fuld & Company today announced that Wayne Rosenkrans, ... specializing in strategic gaming for the pharmaceutical and healthcare ... "We are excited to have Dr. Rosenkrans join ... accomplishment in the global pharmaceutical industry; government and academia ...
Cached Biology Technology:Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 2Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 3Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 4Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 5Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 6Hawaii LASIK Eye Surgery Expert Dr. John D. Olkowski Qualifies and Lists with Trusted LASIK Surgeons 7Life Sciences Discovery Fund Awards $4.7 Million to Support New Vaccine Program 2Life Sciences Discovery Fund Awards $4.7 Million to Support New Vaccine Program 3Life Sciences Discovery Fund Awards $4.7 Million to Support New Vaccine Program 4Fuld & Company Announces Appointment of MIT Fellow to Head Pharmaceutical Team's Strategic Gaming and Consulting Services 2