Navigation Links
Genetic based human diseases are an ancient evolutionary legacy
Date:10/16/2008

This press release is available in German.

Tomislav Domazet-Loo and Diethard Tautz from the Max Planck Institute for Evolutionary Biology in Pln, Germany, have systematically analysed the time of emergence for a large number of genes - genes which can also initiate diseases. Their studies show for the first time that the majority of these genes were already in existence at the origin of the first cells. The search for further genes, particularly those which are involved in diseases caused by several genetic causes, is thus facilitated. Furthermore, the research results confirm that the basic interconnections are to be found in the function of genes - causing the onset of diseases - can also be found in model organisms (Molecular Biology and Evolution).

The Human Genome Project that deciphered the human genetic code, uncovered thousands of genes that, if mutated, are involved in human genetic diseases. The genomes of many other organisms were deciphered in parallel. This now allows the evolution of these disease associated genes to be systematically studied.

Tomislav Domazet-Loo and Diethard Tautz from the Max Planck Institute for Evolutionary Biology in Pln (Germany) have used for this analysis a novel statistical method, "phylostratigraphy" that was developed by Tomislav Domazet-Loo at the Ruđer Boković Institute in Zagreb (Croatia). The method allows the point of origin for any existing gene to be determined by tracing the last common ancestor in which this gene existed. Based on this information, it is then possible to determine the minimum age for any given gene.

Applying this method to disease genes, the scientists from Pln came to surprising findings. The vast majority of these genes trace back to the origin of the first cell. Other large groups emerged more than one billion years ago around the first appearance of multi-cellular organisms, as well as at the time of origin of bony fishes about 400 million years ago. Surprisingly, they found almost no disease associated genes among those that emerged after the origin of mammals.

These findings suggest that genetic diseases affected primarily ancient cellular processes, which emerged already during the early stages of life on Earth. This leads to the conclusion that all living organisms today, i.e. not only humans, will be affected by similar genetic diseases. Furthermore, this implies that genetically caused diseases will never be beaten completely, because they are linked to ancient evolutionary processes.

Although it was already known that many disease associated genes occur also in other organisms distant to humans, such as the fruitfly Drosophila or the round worm Caenorhabditis, the analysis of Domazet-Loo and Tautz shows now for the first time that this is systematically true for the vast majority of these genes. At present it remains unknown why the more recently evolved genes, for example those involved in the emergence of the mammals, do not tend to cause diseases when mutated.

The research results of the scientists from Pln also have some practical consequences. It will now be easier to identify candidates for further disease genes, in particular for those involved in multi-factorial diseases. Furthermore, the results confirm that the functional knowledge gained about such genes from remote model organisms is also relevant for understanding the genes in humans.


'/>"/>

Contact: Professor Dr. Diethard Tautz
tautz@evolbio.mpg.de
49-452-276-3390
Max-Planck-Gesellschaft
Source:Eurekalert  

Related biology news :

1. Modern genetics vs. ancient frog-killing fungus
2. The American Society of Human Genetics hosts 58th Annual Meeting in Philadelphia
3. Can genetic information be controlled by light?
4. Clue to genetic cause of fatal birth defect
5. American College of Medical Genetics receives $13.5M NIH contract
6. Genetic finding implicates innate immune system in major cause of blindness
7. Study finds genetic variant plays role in cleft lip
8. Genetic Engineering & Biotechnology News reports on growing role of molecular diagnostics
9. Rare genetic disorder gives clues to autism, epilepsy, mental retardation
10. Childrens Hospital researchers identify genetic mutation that may predict organ rejection
11. K-State professors USDA research shows mad cow disease also caused by genetic mutation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Genetic based human diseases are an ancient evolutionary legacy
(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology: