Navigation Links
Genetic analysis of amniotic fluid shows promise for monitoring fetal development
Date:8/7/2011

Philadelphia, PA, August 8, 2011 Researchers have demonstrated the feasibility of focused fetal gene expression analysis of target genes found in amniotic fluid using Standardized NanoArray PCR (SNAP) technology. This analysis could be used to monitor fetal development, enabling clinicians to determine very early in pregnancy whether fetal organ systems are developing normally. The study appears today in the September issue of The Journal of Molecular Diagnostics.

Using a previously developed SNAP gene panel as proof of concept, investigators from the Floating Hospital for Children at Tufts Medical Center, Mount Sinai School of Medicine, and Prevail Dx determined that 7 of the 21 genes assayed were expressed differently depending on fetal sex or gestational age. Results were obtained from amniotic fluid supernatant samples from fetuses between 15 to 20 weeks of gestation, when standard amniotic fluid testing is performed.

"In the future, fetal gene expression panels could prove useful in prenatal care to evaluate function in cases of at-risk pregnancies and fetal pathologies," commented lead investigator Lauren J. Massingham, MD, Division of Genetics, Department of Pediatrics, Floating Hospital for Children at Tufts Medical Center, Boston, Massachusetts. According to the investigators, further studies using this gene panel approach could elucidate the complex immune pathways involved in the maternal-fetal relationship.

Dr. Massingham added, "Some genes in the current panel may prove to be useful components of a fetal gene expression panel. Future studies are warranted to identify additional genes to be incorporated, including inflammatory, developmental, and gastrointestinal genes. This technique could be optimized to examine specific genes instrumental in fetal organ system function, which could be a useful addition to prenatal care."

SNAP technology allows for the simultaneous quantitative assessment of tens to hundreds of genes from reduced and degraded nucleic acid samples, overcoming the quality concerns of processing primary human samples. Gene expression that varies by up to five orders of magnitude can be quantified using a single assay.


'/>"/>

Contact: David Sampson
jmdmedia@elsevier.com
215-239-3171
Elsevier Health Sciences
Source:Eurekalert

Related biology news :

1. Scientist urges government ruling on genetically engineered salmon
2. Michigan State scholar leads effort to reform genetics instruction
3. Disappearance of genetic material allows tumor cells to grow
4. Plant biologists dissect genetic mechanism enabling plants to overcome environmental challenge
5. AgriLife Research genetically fingerprinting E. coli from watersheds
6. National asthma genetics consortium releases first results
7. Genetic evidence clears Ben Franklin
8. Mismatch between cancer genetics counseling and testing guidelines and physician practices
9. 2 genetic variations predict second cancers after radiation for children with Hodgkin lymphoma
10. Epigenetic memory key to nature versus nurture
11. Life scientists use novel technique to produce genetic map for African Americans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)... , Feb. 13, 2017  RSA Conference -- ... platform that is designed to enhance fraud detection ... release in the RSA Fraud & Risk Intelligence ... organizations to leverage additional insights from internal and ... to better protect their customers from targeted cybercrime ...
(Date:2/10/2017)... -- Research and Markets has announced the ... Scientific and Commercial Aspects" to their offering. ... Biomarkers play ... therapy for selection of treatment as well for monitoring the ... disease in modern medicine. Biochip/microarray technologies and next generation sequencing ...
(Date:2/8/2017)... 8, 2017 About Voice Recognition Biometrics Voice ... it against a stored voiceprint template. Acoustic features ... and tone are compared to distinguish between individual ... as most PCs already have a microphone and ... recognition biometrics are most likely to be deployed ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... CAMBRIDGE, Mass. , March 22, 2017 ... announced that it has eclipsed the 130 million covered ... Cross Blue Shield of Texas . ... stages, the Company continues to enjoy strong payor acceptance ... of its clinical programs and genetic counseling, its industry-leading ...
(Date:3/22/2017)... LEXINGTON, Mass. , March 22, 2017   ... collections, today announced that Doctors Pathology Service ... mid-Atlantic region of the United States ... the Delaware Health Information Network (DHIN) to ... researchers. The novel program, announced in ...
(Date:3/22/2017)... , March 22, 2017 MarketNewsUpdates.com ... ... cancer conditions are being pressured as of late due to ... cancer pain management has a dramatic impact on patient,s quality ... and development activities for identifying new forms of opioid formulations ...
(Date:3/22/2017)... --  Boston Biomedical , an industry leader in the ... stemness pathways, today announced its Board of Directors has ... Officer, effective April 24, 2017. Ms. ... FACP, who has led Boston Biomedical since he founded ... Biomedical has grown from a "garage startup" without technology ...
Breaking Biology Technology: