Navigation Links
Genetic aberration paves the way for new treatment of cancer disease
Date:11/6/2013

12-15 years of development and millions of dollars are typically the costs, when companies develop a new anti-cancer drug. Therefore all short cuts to a treatment are welcome. Researchers at Department of Veterinary Disease Biology, University of Copenhagen, recently discovered such a potential short cut.

"Our new research shows, that we might be able to introduce a treatment faster and cheaper than usual in the development of cancer treatment, and we estimate that it will be efficient in around 10 per cent of patients with colorectal cancer," says MD and PhD student Sune Nygrd, Department of Veterinary Disease Biology, University of Copenhagen.

Re-use of existing breast cancer treatment

In the new study the researchers have shown that around 10 per cent of colorectal cancer patients harbor an aberration in the gene called TOP2A in their cancer cells. These tumors could potentially benefit from treatment with a specific chemotherapeutic drug a so-called "anti-TOP2A treatment", which is already used in breast cancer patients with this gene aberration.

Clinical study begins

Approximately 600,000 patients die of colorectal cancer each year worldwide.

"If the first treatment doesn't cure a patient with colorectal cancer, the possibilities of additional treatment are limited," says Nils Brnner, MD, professor at University of Copenhagen.

"Therefore it is very important to find a new, efficient treatment," he adds.

The research group from the Department of Veterinary Disease Biology and professor Per Pfeiffer at Odense University Hospital have received funds from The Danish Cancer Society to initiate a clinical trial. Here it will be tested, if patients with the TOP2A gene defect could benefit from the targeted anti-TOP2A treatment.

"It is unique to go from a discovery in the laboratory towards a treatment for cancer patients at this pace. This is only possible when researchers and doctors work closely together," says Nils Brnner, University of Copenhagen.


'/>"/>

Contact: Nils Brünner
nbr@sund.ku.dk
45-26-14-47-08
University of Copenhagen
Source:Eurekalert

Related biology news :

1. Genetic study proves Israels wild boars originated in Europe
2. Dolphin genetic study provides revelations
3. Genetic rarity rules in wild guppy population, study finds
4. GenSeq: Updated nomenclature for genetic sequences to solve taxonomic determination issues
5. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
6. HIV -- Geneticists map human resistance to AIDS
7. Measuring segments of genetic material may help predict and monitor recurrence after thyroid cancer
8. Genetic variants associated with bronchodilator responsiveness
9. EUREKA grant to fund development of new optogenetic technique for mapping neural networks at UMMS
10. New software traces origins of genetic disorders 20 times more accurately
11. 2 genetic wrongs make a biochemical right
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2017)... , Feb. 13, 2017 Former 9/11 ... Senate Judiciary Committee, Janice Kephart of Identity ... President Donald Trump,s "Executive Order: Protecting the ... (Jan. 27, 2017):  "As President Trump,s ,Travel ... Circuit has now essentially banned the travel ban, it ...
(Date:2/8/2017)... Report Highlights ... The global synthetic-biology market reached nearly $3.9 ... growing at a compound annual growth rate (CAGR) of 24.0% ... global markets for synthetic biology. - Analyses of global market ... of compound annual growth rates (CAGRs) through 2021. - Coverage ...
(Date:2/7/2017)... , February 7, 2017 Ipsidy ... Solutions Corporation [OTC: IDGS], ("Ipsidy" or the "Company") a ... transaction processing services, is pleased to announce the following ... Effective January 31, 2017, Philip D. ... Directors, CEO and President.  An experienced payment industry professional ...
Breaking Biology News(10 mins):
(Date:2/24/2017)...  OncoSec Medical Incorporated ("OncoSec") (NASDAQ: ONCS), a company ... Opinion Leader event to highlight new clinical data that ... at the upcoming 2017 ASCO-SITC Immuno-Oncology Symposium and the ... held in-person and via live webcast on Tuesday, February ... at the Lotte New York Palace Hotel in ...
(Date:2/23/2017)... ... February 23, 2017 , ... BellBrook ... portfolio to include an array of biochemical analyses critical for Lead Discovery. ... their hit-to-lead and SAR programs, including inhibitor potency and selectivity, mechanism of action, ...
(Date:2/23/2017)... , Feb. 23, 2017  In Atlanta, it seems everyone ... and culture intertwine to create an expressive and dynamic community ... this energy and contribute to it. With ... Hair Fairies seeks to carry on that tradition with ... Atlanta salon is the newest of 13 ...
(Date:2/23/2017)... ... February 23, 2017 , ... Brain Sentinel, Inc. has ... the SPEAC® System, the Brain Sentinel® Seizure Monitoring and Alerting System. The adjunctive ... during periods of rest. A lightweight, non-invasive monitor is placed on the belly ...
Breaking Biology Technology: