Navigation Links
Genes that both extend life and protect against cancer identified
Date:10/14/2007

A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal Nature Genetics identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm.

Many of the worm genes have counterparts in humans, suggesting that new drugs may some day ensure a long, cancer-free life. The new research and a related study the scientists reported in Science last year indicate that cellular changes leading to longevity antagonize tumor cell growth.

The studies are by scientists at the University of California, San Francisco, who say the research also underscores the deep evolutionary connection between lifespan and cancer.

The worms, known formally as Caenorhabditis elegans, were the stars of a startling 1993 discovery by UCSF biologist Cynthia Kenyon, PhD. She found then that a change in just one gene, called daf-2, doubled the worms lifespan. This finding led to the understanding that lifespan is regulated by genes and is therefore changeable, rather than the inevitable result of the bodys breakdown. The discovery in worms has been confirmed in other animals including mice.

The new research by Kenyon and graduate student Julie Pinkston is reported in the advanced online edition of the journal.

Kenyon is the American Cancer Society Professor and director of the Hillblom Center for the Biology of Aging at UCSF.

This is very exciting, Kenyon said. There is a widely held view that any mechanism that slows aging would probably stimulate tumor growth. But we found many genes that increase lifespan, but slow tumor growth. Humans have versions of many of these genes, so this work may lead to treatments that keep us youthful and cancer-free much longer than normal.

Since her early finding that the gene daf-2 and another gene known as daf-16 regulate lifespan, Kenyons research team h
'/>"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. Newly-discovered class of genes determines ?and restricts ?stem cell fate
3. Inexpensive, mass-produced genes core of synthetic biology advances at UH
4. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. U-M scientists find genes that control growth of common skin cancer
7. Researchers find missing genes of ancient organism
8. Scientists document complex genomic events leading to the birth of new genes
9. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
10. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
11. Advances in the characterisation of the oyster mushroom genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the ... APAC Region 2015-2019"  report to their offering. ... market is advances in technology. With continuous advances ... solutions to the latest standard that meets the ...
(Date:12/10/2014)... -- You,ve been here before: you desperately need to sign ... site key or the answer to your secret question. What,s ... Today, Hoyos Labs , a digital infrastructure ... put an end to the frustration that comes with usernames, ... leverages a user,s smartphone to acquire his or her biometrics ...
(Date:12/10/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/xclcvw/biometrics_market ) ... Market in Japan 2014-2018" report to their ... The integration of biometrics and smart ... upgradation of the driver,s license is one of ... the aforementioned projects, biometrics is being used as ...
Breaking Biology News(10 mins):Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... , Sept. 4, 2013  Rapid growth in microRNA (miRNA) ... its diagnostic and therapeutic potential, has fuelled development ... Of the various miRNA technologies, which include quantitative ... functional tools, qRT PCR remains the fastest-growing, while ...
... . Families of thousands of victims of ... appropriate punishment, because of a suite of technologies able ... graves, perhaps hundreds of thousands remain undiscovered. Researchers at ... Ridge National Laboratory are developing a method to discover ...
... pleased to announce that the 2014 HFSP Nakasone Award ... Institute of Science for his pioneering work in discovering ... single most important foundation of the field of systems ... of genetic circuits to systematic analysis and understanding. ...
Cached Biology News:Frost & Sullivan: Diagnostic and Therapeutic Potential of microRNAs Stimulate Need for More Research Tools 2Frost & Sullivan: Diagnostic and Therapeutic Potential of microRNAs Stimulate Need for More Research Tools 3Frost & Sullivan: Diagnostic and Therapeutic Potential of microRNAs Stimulate Need for More Research Tools 4September 2013 story tips 2September 2013 story tips 3The 2014 HFSP Nakasone Award goes to Uri Alon 2
(Date:12/19/2014)... PLEASANTON, Calif. , Dec. 19, 2014  Roche ... acquisition of Bina Technologies, Inc. (Bina), a privately ... California , USA. Bina provides a big ... next generation sequencing (NGS) data. Bina,s proprietary on-market ... translational and academic researchers to perform fast and ...
(Date:12/19/2014)... , Dec. 19, 2014 Research and Markets ... addition of the "Technology Innovations in Smart ... http://photos.prnewswire.com/prnh/20130307/600769 ... Smart Fabrics" offers a detailed assessment on technological ... Key Findings: 1. The Smart ...
(Date:12/19/2014)... 18, 2014 LayerBio is an MIT ... wound care. The National Eye Institute (NEI) at the ... Phase I SBIR grant to develop a drug-eluting intraocular ... most common cause of vision loss in people over ... According to Dr. Ken Mandell, LayerBio’s Founder and CEO, ...
(Date:12/19/2014)... (PRWEB) December 18, 2014 iLab Solutions, ... the appointment of Siri Bryant as the new Director ... Director of Core Implementations. These two new leadership positions ... customer service by ensuring that iLab continues to meet ... the last four years, iLab has been deployed at ...
Breaking Biology Technology:Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Technology Innovations in Smart Fabrics (Technical Insights) 2LayerBio Awarded NIH Grant to Develop a Drug Delivery Device for Cataract Surgery 2iLab Solutions Announces Two New Leadership Positions to Meet the Needs of Its Growing Customer Base 2
... non-profit arm the SBC Foundation, has given $285,500 in ... Milwaukee has reported. , ,Twenty-four organizations that ... received money to help them use more technology. The ... which typically gives from $2,500 to $25,000 per organization. ...
... secretary of Wisconsins Department of Commerce, said on Friday that he ... partner in the law firm Quarles & Bradys Milwaukee office. , ... two years. He will be returning to the firm he worked ... deal from Governor Doyle as a leader, a boss, and a ...
... Having judged last years a success, the Wisconsin ... the second annual Wisconsin Governor's Business Plan Contest ... businesses will submit 250-word business proposals within one of ... business services. The proposals will be accepted until January ...
Cached Biology Technology:Secretary Nettles leaving Commerce for law practice 2Secretary Nettles leaving Commerce for law practice 3Governors business-plan competition starts another round 2Governors business-plan competition starts another round 3
... The SPD101B is a no-frills, basic SpeedVac ... Although economically priced, this unit still features ... a digitial display of time and heat. ... samples and accepts a wide variety of ...
Digital display of time, vacuum and temperature , Dual vacuum control of ramping rate and ultimate level , Comes complete with RH40-12 (40 x 1.5 ml) Rotor and (2) Glass Condensation Flasks. ...
... The DNA120 is a dedicated concentrator for ... precipitates of DNA/RNA. The integrated system combines ... pump. The compact design, automatic pump and ... run time; one for heater time), makes ...
For absolute protein quantification. 4 peptides in 5 vials x 2 nmol per peptide...
Biology Products: