Navigation Links
Genes that both extend life and protect against cancer identified
Date:10/14/2007

A person is 100 times more likely to get cancer at age 65 than at age 35. But new research reported today in the journal Nature Genetics identifies naturally occurring processes that allow many genes to both slow aging and protect against cancer in the much-studied C. elegans roundworm.

Many of the worm genes have counterparts in humans, suggesting that new drugs may some day ensure a long, cancer-free life. The new research and a related study the scientists reported in Science last year indicate that cellular changes leading to longevity antagonize tumor cell growth.

The studies are by scientists at the University of California, San Francisco, who say the research also underscores the deep evolutionary connection between lifespan and cancer.

The worms, known formally as Caenorhabditis elegans, were the stars of a startling 1993 discovery by UCSF biologist Cynthia Kenyon, PhD. She found then that a change in just one gene, called daf-2, doubled the worms lifespan. This finding led to the understanding that lifespan is regulated by genes and is therefore changeable, rather than the inevitable result of the bodys breakdown. The discovery in worms has been confirmed in other animals including mice.

The new research by Kenyon and graduate student Julie Pinkston is reported in the advanced online edition of the journal.

Kenyon is the American Cancer Society Professor and director of the Hillblom Center for the Biology of Aging at UCSF.

This is very exciting, Kenyon said. There is a widely held view that any mechanism that slows aging would probably stimulate tumor growth. But we found many genes that increase lifespan, but slow tumor growth. Humans have versions of many of these genes, so this work may lead to treatments that keep us youthful and cancer-free much longer than normal.

Since her early finding that the gene daf-2 and another gene known as daf-16 regulate lifespan, Kenyons research team h
'/>"/>

Contact: Wallace Ravven
wravven@pubaff.ucsf.edu
415-476-2557
University of California - San Francisco
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. Newly-discovered class of genes determines ?and restricts ?stem cell fate
3. Inexpensive, mass-produced genes core of synthetic biology advances at UH
4. Protein Packages Found To Activate Genes; May Be What Regulates Development And Disease
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. U-M scientists find genes that control growth of common skin cancer
7. Researchers find missing genes of ancient organism
8. Scientists document complex genomic events leading to the birth of new genes
9. VCU Researchers Identify Networks Of Genes Responding To Alcohol In The Brain
10. Genrate: a generative model that finds and scores new genes and exons in genomic microarray data
11. Advances in the characterisation of the oyster mushroom genes

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/1/2009)... Ohio State University cancer researchers have de...rain-tumor cells and blocks the growth of new tumo...uses designed to kill cancer cells oncolytic viru...ain tumors if they also carry a gene for a protein..., called vasculostatin, is normally produced in th...
(Date:12/1/2009)...W YORK, Dec. 1 iQor, a global prov...s, was included in the 2009 InfoWorld 100 Awards...led ERP system, TeQ21. This was the first submissi...d among this prestigious list of companies," said ... completely transforming the way we do business, a...
(Date:12/1/2009)...ke a bad cold, can spread among groups of people, ...ity of California-San Diego and Harvard shows., ...hat has been following health conditions for more ...y people tend to share their loneliness with other...ected people moves to the fringes of social networ...
Breaking Biology News(10 mins):Tumor-attacking virus strikes with 'one-two punch' 2iQor Named to InfoWorld 100 List of Top IT Projects of 2009 2Loneliness can be contagious 2Loneliness can be contagious 3Putney Inc Enters the 24175M Annual Veterinary NSAID Market 49830 1Putney Inc Enters the 24175M Annual Veterinary NSAID Market 49830 2CorNova 28R 29 Receives CE Mark Approval for Valecor Platinum 28R 29 Coronary Stent System 49827 1CorNova 28R 29 Receives CE Mark Approval for Valecor Platinum 28R 29 Coronary Stent System 49827 2Cinergy Health Commentary On President Obamas Call for Cost Control Competition in Health Insurance Arena 49824 1Cinergy Health Commentary On President Obamas Call for Cost Control Competition in Health Insurance Arena 49824 2
... New Brunswick, N.J. The National Science Founda...ent of Homeland Security (DHS), has awarded Rutger...ing smuggled nuclear materials. The work aims to t...lop dirty bombs or environmental contaminants that... paralyze commerce. , The NSF has committed $631,...
... By mining evidence from the classic films made b...that the left-handed minority suffered something o... of the 20th century. In more recent times, leftie...ort in the Sept. 18, 2007, Current Biology, a publ...portant because more than 10 percent of people hav...
... Washington DC*-- Key components of a new approac...hed into space Friday as part of a twelve-day, low...ity in the space radiation environmenta prelude fu...d on technology similar to that used in pregnancy ... in the Life Marker Chip (LMC) experiment, which h...
Other Biology News:Homeland Security awards 2 grants to Rutgers for nuclear threat detection 2Homeland Security awards 2 grants to Rutgers for nuclear threat detection 3Films of Mitchell and Kenyon illuminate lefties' decline in Victorian England 2Life on Mars 'pregnancy test' successfully launched 2
(Date:12/1/2009)...SPRINGFIELD, Ill., Dec. 1 Prairie ...nounce that it was recently awarded two statuettes... Nov. 13 in New York City. The CLIO Healthcare Awa...in the healthcare advertising industry and is an e...st recognized awards competitions for advertising,...
(Date:12/1/2009)... EpiVax, Inc. today announced a collabor... OTCQX: RHHBY) aimed at evaluating EpiVax’s ...ntially reduce detrimental immune responses to cer...aboration, the EpiVax Tregitope technology will be...of protein therapeutics. , ...
(Date:12/1/2009)... , SAN DIEGO, Dec. 1 ...nnounced today that it will present at the LD MICR... p.m. (PST) at the Luxe Hotel in Los Angeles. Aeth...ll present a corporate overview and will provide a...s lead product, the Hemopurifier®, a first-in...
(Date:12/1/2009)..., HARBIN, China, Dec. 1 /PRNewswire-Asia-Fi...y One Medical" or "the Company") (Nasdaq: CSKI ),... developing and producing,over-the-counter drugs i...nounced that the Company has engaged Guangdong Med... ("MDK") to serve as its exclusive sales agent for...
Breaking Biology Technology:Prairie Heart Institute of Illinois Wins Two CLIO Healthcare Awards 2EpiVax, Inc. forms Collaborative Research Agreement with Roche to Develop Tregitope Technology 2EpiVax, Inc. forms Collaborative Research Agreement with Roche to Develop Tregitope Technology 3Aethlon Medical to Present at LD MICRO Conference on December 3, 2009 2China Sky One Medical, Inc. Signs Distribution Agreement with MDK for the Sale of Two Diagnostic Kits in Southeast Asia 2China Sky One Medical, Inc. Signs Distribution Agreement with MDK for the Sale of Two Diagnostic Kits in Southeast Asia 3
... The American Institute of Aeronautics and Astrona...ulsion Science , that compiles for the first time ...epts as space drives, warp drives, gravity control...would revolutionize spaceflight and enable human v...t matter may sound like science fiction, authors M...
...y 3 deCODE genetics,(Nasdaq: DCGN ) announced th...the Nasdaq Listing Qualifications Panel (the "Pane...ng of deCODE,s common stock from the Nasdaq Global... the open of the trading,session on Wednesday, Feb...,one of the three market tier designations for Nas...
...sty, Inc. (Amex: UPI ),a medical device company ...,proprietary products to treat voiding dysfunction...quarter of fiscal 2009 ended December 31, 2008. N... $3.4 million versus $3.7,million during last fisc... conjunction with the release of our fiscal second...
Other Biology Technology:New book from AIAA explores space drives, warp drives 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 2deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market 3Uroplasty Reports Third Quarter Fiscal 2009 Results 2Uroplasty Reports Third Quarter Fiscal 2009 Results 3Uroplasty Reports Third Quarter Fiscal 2009 Results 4Uroplasty Reports Third Quarter Fiscal 2009 Results 5Uroplasty Reports Third Quarter Fiscal 2009 Results 6Uroplasty Reports Third Quarter Fiscal 2009 Results 7Uroplasty Reports Third Quarter Fiscal 2009 Results 8Uroplasty Reports Third Quarter Fiscal 2009 Results 9Uroplasty Reports Third Quarter Fiscal 2009 Results 10Uroplasty Reports Third Quarter Fiscal 2009 Results 11
GenomePlex Single Cell Whole Genome Amplification Kit from Sigma-Aldrich
Buffer for sal I 10X (do not list in catalog) BLACK (Sal I) from Sigma-Aldrich
Calf Serum, Iron-Supplemented from Sigma-Aldrich
Fetal Calf Serum from Quad Five
Biology Products: