Navigation Links
Gene's 'selective signature' aids detection of natural selection in microbial evolution
Date:3/18/2008

Scientists at MIT have come up with a mathematical approach for analyzing a protein simultaneously in a set of ecologically distinct species to identify occurrences of natural selection in an organisms evolution.

The new method determines the selective signature of a gene, that is, the pattern of fast or slow evolution of that gene across a group of species, and uses that signature to infer gene function or to map changes to ecological shifts.

By reversing the usual order of inquirystudying an organism, then trying to identify which genes are involved in a particular functionthe scientists hope to hasten the understanding of microbial evolution by taking advantage of the nearly 2,500 microbes already sequenced.

By comparing across species, we looked for changes in genes that reflect natural selection and then asked, How does this gene relate to the ecology of the species it occurs in? said Eric Alm, the Doherty Assistant Professor of Ocean Utilization in the Department of Civil and Environmental Engineering. The selective signature method also allows us to focus on a single species and better understand the selective pressures on it.

Our hope is that other researchers will take this tool and apply it to sets of related species with fully sequenced genomes to understand the genetic basis of that ecological divergence, said graduate student B. Jesse Shapiro, who co-authored with Alm a paper published in the February issue of PLoS Genetics.

Their work also suggests that evolution occurs on functional modulesgenes that may not sit together on the genome, but that encode proteins that perform similar functions.

When we see similar results across all the genes in a pathway, it suggests the genomic landscape may be organized into functional modules even at the level of natural selection, said Alm. If thats true, it may be easier than expected to understand the complex evolutionary pressures on a cell.


'/>"/>

Contact: Denise Brehm
brehm@mit.edu
617-253-8069
Massachusetts Institute of Technology, Department of Civil and Environmental Engineering
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/12/2015)... Florida , August 12, 2015 ... pace of mobile payment innovation and advanced biometrics technology ... replace the way consumers rely on using their credit ... with reinventing the future for payment services led by ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ...
(Date:8/10/2015)... , August 10, 2015 ... Eye Tracking Technology for more than two decades, announces ... for integration into all consumer display formats. The SMI ... integration of eye tracking into consumer tablets, laptops, desktop ... smart glasses. Omnivision,s leading sensor technology contributes to the ...
(Date:8/6/2015)... Calif. , Aug. 6, 2015 ... developer of human interface solutions, today announced collaboration ... technologies on Windows 10. Microsoft leveraged Synaptics, deep ... the operating system. Through stringent ... are fully certified with Microsoft,s Precision TouchPad (PTP) ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Synaptics Chosen for Human Interface Co-Development on Windows 10 2
... of continental drift provides a good model for understanding terrestrial ... successfully shed light on processes up to 3 billion years ... the earth and crust formation before that point and through ... ago. This is the conclusion of Tomas Naraa of the ...
... tissue using cells derived from the amniotic fluid is ... UCL Institute of Child Health. The paper ... cells derived from the fluids which surround the fetus ... The treatment resulted in longer survival in mice affected ...
... Inc., a Los Angeles based investment banking company, today ... Alliqua, Inc.  During the term of the engagement, WestPark ... and finance, private and public equity and debt financing, ... provide introductions to investors. About Alliqua, ...
Cached Biology News:New understanding of terrestrial formation has significant and far reaching future implications 2Potential new approach to regenerating skeletal muscle tissue 2WestPark Capital, Inc. Engaged By Alliqua, Inc. 2
(Date:8/31/2015)... -- Trimb Healthcare AB ("Trimb") today announced that it ... ("YouMedical"), a Dutch OTC company with operations in key ... EUR 16 million, with solid growth and leading brands ... to build a leading international OTC company, and this ... gives us a stronger North European OTC platform, from ...
(Date:8/31/2015)... ... August 31, 2015 , ... Proove Biosciences, Inc. is a finalist for the ... Tech Awards. , Now in its 22nd year, this premier awards event celebrates the ... the nation and around the world. The OC Tech Alliance will announce all winners ...
(Date:8/28/2015)... ... August 28, 2015 , ... ... presented two studies at the International Spine Intervention Society’ s 23rd ... through to August 1st, 2015. With a focus on evidence-based research and clinical ...
(Date:8/28/2015)... ... 2015 , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company ... Images such as the Fonz in a lab coat and Large Marge have been ... spectroscopy field. , FireflySci is proud to be the only cuvette manufacturer is ...
Breaking Biology Technology:Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 2Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 3Proove Biosciences, Inc. Named a Finalist for 22nd OC Tech Alliance High-Tech Awards for Company of the Year 4Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2
... This release is available in German . When ... light particles, so-called photons, carry sufficient energy, the electrons can be ... was explained by Einstein more than hundred years ago. Until now, ... the atom immediately after the impact of the photon. This point ...
... ... case study that provides a sustainable solution for odor and pathogen ... of beneficial microbial applications. These results are intended to address the ... who recently agreed to identify and investigate thousands of factory farms ...
... ... in Latin America regarding approvals of Stemedica’s allogeneic adult stem cell products for use in ... , ... 24, 2010 -- Stemedica Cell Technologies, Inc., a leader in allogeneic adult stem ...
Cached Biology Technology:Delayed time zero in photoemission 2Delayed time zero in photoemission 3Effective Odor and Pathogen Control in Livestock Operations Revealed in New Case Study 2Stemedica Announces the Appointment of Dr. Csar Amescua Garcia as Medical and Regulatory Affairs Director – Latin America 2
...
... 220 utilizes utilizies CTI Molecular Imaging's ... superior resolution, sensitivty, and a large ... the flexibility to image multiple mice ... microPET is a dedicated small animal ...
... StatMatic I provides a convenient and affordable ... work. Used with an eight-port disposable manifold, ... possible with multi-channel pipettes. The eight-port manifold, ... volumes of 100, 200, 250, or 300mL ...
... HRP Stabilizing Diluent (MOPS Buffered) has ... Horseradish Peroxidase conjugates in solution. HRP ... and maintains the conformation of the antibody ... Product is filtered at 0.2 microns., ...
Biology Products: