Navigation Links
Genes may play role in risk assessment for prostate cancer among Hispanics and caucasians

PHILADELPHIA Genetic differences may explain the greater risk for prostate cancer among Caucasian men compared with Hispanic men, which could help clinicians predict who is more likely to develop the disease, according to a paper published in the May 15, 2008, issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.

Currently, the most common method for assessing risk for prostate cancer is the prostate specific antigen test, but this method can identify tumors that may not be a threat to the health of a man and misses other tumors.

Men typically have this test after they turn 50 years old, and it can spot a tumor that may not cause a problem in a mans lifetime if left untreated. It could be more likely that a man will die from heart disease or some other ailment before his prostate cancer would kill him. At this point, it is not possible to accurately tell which tumors will be the more aggressive ones with our current screening tests. This mean that we may be screening and treating some men unnecessarily, said Kathleen Torkko, Ph.D., an instructor in the Department of Pathology at the University of Colorado Denver. The goal of research like this is to better classify a disease so we can move toward better management and treatment.

Prostate cancer is the most commonly diagnosed non-skin cancer and one of the 10 leading causes of death among American men. Compared with white men, Hispanic men have higher rates of cancer overall, but the rate of prostate cancer among Hispanic men, falling just above Asian Americans, is one of the lowest.

This may be due to the fact that we simply are not looking enough because Hispanic men may not have access to screening or could be reluctant to undergo some of the screening procedures that are becoming routine among Caucasian men, said Torkko.

Torkko and colleagues observed 932 white men and 414 Hispanic men from south Texas. They analyzed blood samples to establish the relationship between the presence of genetic polymorphisms and the risk for prostate cancer. Specifically, they observed polymorphisms from the nuclear Vitamin D receptor (CDX2 and FokI), which modulates the actions of Vitamin D, and from 5-reductase type II (V89L & A49T), which converts testosterone to dihydrotestosterone, a more potent form of the male hormone.

Among non-Hispanic white men with V89L, FokI was associated with a more than 50 percent increased risk of prostate cancer. This effect was not seen in Hispanic men. Among Hispanic white men, CDX2 and V89L in combination were linked with a more than three-fold increase in prostate cancer. However, this interaction was not seen in Caucasian men.

Torkko said these results help add a piece to the genetic puzzle of risk and racial differences, but will need to be confirmed by other studies, in larger populations, before they are ready for use in the clinic.

Prostate cancer is not likely caused by a few genes, but by multiple genes from different pathways. This study illustrates the importance of examining multiple genes to understand genetic risks for prostate cancer and differences seen by ethnicity, Torkko said. Going forward, we need not only a better understanding of genetics but a better understanding of race and ethnicity. Studying disease by race is a complex issue, and the public needs to understand that we are trying to raise biological, rather than social, questions.


Contact: Jeremy Moore
American Association for Cancer Research

Related biology news :

1. Gene regulation, not just genes, is what sets humans apart
2. Interaction of just 2 genes governs coloration patterns in mice
3. Muscle mass: Scientists identify novel mode of transcriptional regulation during myogenesis
4. Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems
5. Smoking turns on genes -- permanently
6. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
7. Hebrew SeniorLife researchers search for aging, osteoporosis genes
8. UT Southwestern researchers identify hundreds of genes controlling female fertility
9. Genes and environment grant funds close look at nature-nurture overlap in common diseases
10. Jumping genes could make for safer gene delivery system
11. Genes from the father facilitate the formation of new species
Post Your Comments:
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/23/2016)... 23, 2016 ... Gesichts- und Stimmerkennung mit Passwörtern     ... MESG ), ein führender Anbieter digitaler ... mit SpeechPro zusammenarbeitet, um erstmals dessen Biometrietechnologie ... die Möglichkeit angeboten, im Rahmen mobiler Apps ...
(Date:3/21/2016)... Massachusetts , March 22, 2016 ... facial recognition with passcodes for superior security   ... ), a leading provider of secure digital communications services, ... their biometric technology and offer enterprise customers, particularly those ... secure facial recognition and voice authentication within a mobile ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... quality, regulatory and technical consulting, provides a free webinar on Performing ... July 13, 2016 at 12pm CT at no charge. , Incomplete investigations are ...
Breaking Biology Technology: