Navigation Links
Genes linked with lupus are revealed, giving hope for new treatments
Date:1/20/2008

genes affect the function of B cells, which play a key role in the production of antibodies. Autoantibodies, which attack the body's own proteins, contribute to the damage done to the body in Lupus.

The new research also confirms links identified in previous studies between Lupus, as well as other autoimmune diseases, and certain other genes.

Professor Timothy Vyse, a Wellcome Trust Senior Fellow from the Division of Medicine at Imperial College London, and one of the authors of the study, said: "Lupus is a complex disease, which is hard to diagnose, and it can cause many different and unpredictable problems for patients. Living with Lupus can be really tough. We currently can treat the disease by suppressing the immune system, but we urgently need to understand in much more detail what goes wrong with the immune system so that we can design better treatments. This study represents a milestone in progress towards unravelling the secrets of the disease.

"We are continuing to work on refining these genetic studies. Blood samples from patients with Lupus have helped us already and we are very grateful to those who have given us samples. We always need more samples and would like to hear from anyone with Lupus who would like to help us by giving blood samples for this important research," added Professor Vyse.

The researchers reached their conclusions after comparing the genetic makeup of 720 women of European descent with Lupus and 2,337 women without Lupus. They looked at mutations in the building blocks, called nucleotides, which make up DNA.

There are mutations in around one in every 600 nucleotides and the scientists examined over 317,000 how many of these mutations to find those specific to Lupus. These mutations are known as single-nucleotide polymorphisms.

The researchers confirmed their results by comparing another set of genetic data for 1,846 women with Lupus and 1,825 women without Lupus.

'/>"/>
Contact: Laura Gallagher
L.Gallagher@imperial.ac.uk
44-020-759-46702
Imperial College London
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Body weight influenced by thousands of genes
2. Study locates cholesterol genes; finds surprises about good, bad cholesterol
3. 2 genes are important key to regulating immune response
4. Evolution with a restricted number of genes
5. When shes turned on, some of her genes turn off
6. Feinstein researchers develop new genetic method and identify novel genes for schizophrenia
7. Duke scientists map imprinted genes in human genome
8. Manure management reduces levels of antibiotics and antibiotic resistance genes
9. New book defines promising young field of adult neurogenesis
10. Evolutionary comparison finds new human genes
11. Genes influence age-related hearing loss
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... such as heart disease, epilepsy and pain, making them ... is still much scientists do not know about the ... into the structure of sodium channels and, specifically, one ... responsible for ,fine-tuning, the activity of the channel. The ... the Journal of Biological Chemistry . , Nerves ...
(Date:4/17/2014)... the genetic information of DNA is used to ... numerous different functions in living organisms. Messenger RNA ... expression, by relating the genetic information of DNA ... , By examining the different types and ... at a given time, researchers can determine which ...
(Date:4/17/2014)... led by the Australian National University (ANU), have ... and deep-sea temperature variability over the past 5.3 ... understand the climate surrounding ice ages over the ... the relationship between carbon dioxide levels, global temperatures ... University of Southampton (UoS) and the National Oceanography ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2Rapid and accurate mRNA detection in plant tissues 2Ancient sea-levels give new clues on ice ages 2
... contain genetically identical clones up to 15 kilometers apart, suggesting ... of years old, as reported in the Feb. 1 issue ... The seagrass, Posidonia oceanica , reproduces asexually, which can ... old. To investigate the P. oceanica meadow, the ...
... suffering from severe pulmonary diseases including emphysema, lung cancer ... the best chance for survival. The surgical procedure, however, ... lungs and rejection of transplanted tissue by the recipient,s ... Vermont Lung Center (Principal Investigator for this project) in ...
... innovative products and technologies that promote healing of difficult, ... described in the premier issue of Advances in ... Ann Liebert, Inc. ( http://www.liebertpub.com ) and an Official ... available free online at http://www.liebertpub.com/wound Several ...
Cached Biology News:Lungs clothed in fresh cells offer new hope for transplant patients 2Lungs clothed in fresh cells offer new hope for transplant patients 3
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Toronto, Canada (PRWEB) January 14, 2014 ... and its motives and methods in product development and ... of the industry. This mistrust, fueled by concerns about ... further fed by reports of spectacular fines to the ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3
... Life Corporation Limited (HKLife) announces further developments of ... EFADchip technology at the BIO 2009 ... in Atlanta, through 18-21 May 2009. The BIO ... the biotechnology industry and attracts the biggest names ...
... Anti-Cancer Compound Discovered During Joint Research EMERYVILLE, Calif., May ... ) today announced that it has filed a complaint ... District of California asserting its rights to a Phase ... and Bayer. In its complaint, Onyx seeks a ...
... Of the 92 naturally occurring elements, add another to the ... Ph.D., professor of physics in Arts & Sciences at Washington ... doctoral student at the time discovered that europium becomes ... atmospheres) of pressure, making it the 53rd known elemental superconductor ...
Cached Biology Technology:A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis 2A New Era in the Application of Lab-on-a-Chip to Rapid Point-of-Care Diagnosis 3Onyx Pharmaceuticals Files Complaint Against Bayer Corporation 2Europium discovery 2Europium discovery 3
... corresponds to amino acids 2-105 from human ... successfully used in Western blot, immunocytochemistry and ... antibody detects an ~ 60 kDa protein ... been used in immunoprecipitation and immunocytochemical procedures. ...
... suit the widest possible range of sample ... Labware carriers can be placed at any ... for the user, thanks to a numbered ... guided into position. This allows easy removal ...
... was developed in the late 1960s by ... the earliest commercial pioneers of immunoassay in ... in 1987. Sac-Cel rapidly found favour with ... "in house" radioimmunoassays, and became a benchmark ...
... N,N- bis- (3-D-Gluconamidopropyl)deoxycholamide ... analog of CHAPS and CHAPSO. Has reduced ... anion exchange chromatography on DEAE-cellulose. Aggregation number: ... Soluble in H 2 O. Aggregation number ...
Biology Products: